The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.

scientific article

The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2008PLoSO...3.2239R
P356DOI10.1371/JOURNAL.PONE.0002239
P932PMC publication ID2375110
P698PubMed publication ID18493598
P5875ResearchGate publication ID5355950

P50authorDaniel ChamovitzQ17385796
June-Tai WuQ57320915
P2093author name stringDaniel Segal
Cheng-Ting Chien
Yaniv Amir
Sigal Rencus-Lazar
P2860cites workInteractions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin ResponseQ58021755
Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translationQ63976974
Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligasesQ79793647
Silencing of human Int-6 impairs mitosis progression and inhibits cyclin B-Cdk1 activationQ81042711
The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genomeQ24311711
Reconstitution reveals the functional core of mammalian eIF3Q24312641
The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogasterQ24533219
Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasiaQ24676100
FlyBase: anatomical data, images and queriesQ25257918
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasomeQ28200835
The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transitionQ33851941
The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complexQ33891920
Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasomeQ34173343
Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formationQ34779158
Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.Q35803931
Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesisQ36393252
Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expressionQ37170500
Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stabilityQ40673171
Evidence for the transforming activity of a truncated Int6 gene, in vitroQ40782244
Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).Q42817503
COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogasterQ44132450
Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.Q45739186
The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila OogenesisQ46973380
Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation.Q47070899
The COP9 signalosome is essential for development of Drosophila melanogasterQ47070977
Cullin-3 regulates pattern formation, external sensory organ development and cell survival during Drosophila developmentQ47071185
Characterization of the Drosophila ortholog of mouse eIF-3p48/INT-6.Q47071980
Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogasterQ47072211
Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7.Q47822595
CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instabilityQ47845473
Arabidopsis FUSCA5 encodes a novel phosphoprotein that is a component of the COP9 complexQ47963360
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
protein neddylationQ21115705
Nedd8 Dmel_CG10679Q29815883
P304page(s)e2239
P577publication date2008-05-21
P1433published inPLOS OneQ564954
P1476titleThe proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila
P478volume3

Reverse relations

cites work (P2860)
Q45384502An oncogenic role of eIF3e/INT6 in human breast cancer
Q59354954Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation
Q34023306In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling
Q36372104The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.
Q37705403The translation factors of Drosophila melanogaster

Search more.