Posttranslational modifications of proteins in the pathobiology of medically relevant fungi

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Posttranslational modifications of proteins in the pathobiology of medically relevant fungi is …
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scholarly articleQ13442814

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P356DOI10.1128/EC.05238-11
P3181OpenCitations bibliographic resource ID1162469
P932PMC publication ID3272899
P698PubMed publication ID22158711

P50authorMichelle D LeachQ55743461
Alistair J P BrownQ30502927
P2093author name stringA. J. P. Brown
M. D. Leach
P2860cites workEvolution of phosphoregulation: comparison of phosphorylation patterns across yeast speciesQ21145819
SUMO-1 modification of the Wilms' tumor suppressor WT1Q24310548
Ribosomal proteins are targets for the NEDD8 pathwayQ24313502
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2Q24317523
The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2Q24323126
The yeast ubiquitin genes: a family of natural gene fusionsQ24555832
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56Q24633791
The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome systemQ24676115
The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasomeQ24681597
The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8pQ24802316
The ubiquitin systemQ27860803
The role of chromatin during transcriptionQ27860995
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylationQ27931331
Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteinsQ27931364
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109.Q27932154
Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targetsQ27932507
Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I.Q27932996
The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimerQ27933072
Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathwaysQ27933074
Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complexQ27933259
Ubc8p functions in catabolite degradation of fructose-1, 6-bisphosphatase in yeastQ27933816
An essential function of Grr1 for the degradation of Cln2 is to act as a binding core that links Cln2 to Skp1.Q27934791
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replicationQ27935707
Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesionQ27936246
The septins: roles in cytokinesis and other processesQ27936270
Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septinsQ27936336
Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMPQ35197981
Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein inductionQ35208828
Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol responseQ35530373
Proteasomes and molecular chaperones: cellular machinery responsible for folding and destruction of unfolded proteinsQ35544930
SUMO: ligases, isopeptidases and nuclear poresQ35579549
How to activate a damage-tolerant polymerase: consequences of PCNA modifications by ubiquitin and SUMO.Q35601065
Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformansQ35636471
Regulation of apoptosis proteins in cancer cells by ubiquitinQ35691538
On the mechanism of protein palmitoylationQ35936412
Protein arginine methylation in Candida albicans: role in nuclear transportQ35947027
Post-translational modifications influence transcription factor activity: a view from the ETS superfamilyQ36043735
Mitogen-activated protein kinase pathways and fungal pathogenesisQ36095378
Septins may form a ubiquitous family of cytoskeletal filamentsQ36237412
Lingering mysteries of ubiquitin-chain assemblyQ36368593
Two-component signal transduction in human fungal pathogensQ36399917
SUMO-targeted ubiquitin ligases in genome stability.Q36439087
UbiquitinationQ36467132
Co-ordinated covalent modification of G-protein coupled receptorsQ36483090
Comprehensive analysis of glycosylphosphatidylinositol-anchored proteins in Candida albicansQ36692630
Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombeQ43852300
The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress.Q44249813
Multiple Functions of Pmt1p-mediated ProteinO-Mannosylation in the Fungal Pathogen Candida albicansQ44822932
A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linkingQ46181926
Disulfide bond structure and domain organization of yeast beta(1,3)-glucanosyltransferases involved in cell wall biogenesis.Q46603180
The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermisQ47068910
Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicansQ47878543
Molecular characterization of ubiquitin genes from Aspergillus nidulans: mRNA expression on different stress and growth conditionsQ47883191
Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage.Q47949543
The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesisQ48007223
A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiaeQ48017973
Structure of the ubiquitin-encoding genes of cryptococcus neoformansQ48071504
The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis.Q48086255
Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factorQ48402745
SUMO modification of septin-interacting proteins in Candida albicansQ50797640
TheCandida albicans UBI3gene encoding a hybrid ubiquitin fusion protein involved in ribosome biogenesis is essential for growthQ52550234
Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicansQ52566975
Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viabilityQ52599841
Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human bloodQ52939255
The F-box protein Grr1 regulates the stability of Ccn1, Cln3 and Hof1 and cell morphogenesis in Candida albicansQ53598156
PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistanceQ53873705
Systematic study of protein sumoylation: Development of a site-specific predictor of SUMOsp 2.0Q56526462
Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineeringQ57381679
Molecular characterization of ubiquitin genes from Aspergillus nidulans: mRNA expression on different stress and growth conditionsQ60894858
Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural componentQ70226827
Catabolite inactivation of fructose-1,6-bisphosphatase of Saccharomyces cerevisiae. Degradation occurs via the ubiquitin pathwayQ71823930
Catabolite inactivation of fructose-1,6-bisphosphatase in yeast is mediated by the proteasomeQ72107005
Depletion of polyubiquitin encoded by the UBI4 gene confers pleiotropic phenotype to Candida albicans cellsQ73383057
Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligasesQ77652490
Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicansQ77748392
Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signalQ80813947
Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathwaysQ81813867
Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae.Q27936977
Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4.Q27937931
A novel protein modification pathway related to the ubiquitin systemQ27938072
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosisQ27938401
A new protease required for cell-cycle progression in yeastQ27938681
Proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growthQ27939291
The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesisQ27939801
Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modificationQ28116002
An E3-like factor that promotes SUMO conjugation to the yeast septinsQ28188846
Themes and variations on ubiquitylationQ28206411
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replicationQ28209282
SUMO: a history of modificationQ28243325
Protein disulfide isomeraseQ28263008
Palmitoylation of intracellular signaling proteins: regulation and functionQ28266189
Characterization of a Second Member of the Sentrin Family of Ubiquitin-like ProteinsQ28268631
All ras proteins are polyisoprenylated but only some are palmitoylatedQ28270312
Protein prenyltransferasesQ28277579
SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?Q28280175
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activationQ28282094
Proteasome-independent functions of ubiquitin in endocytosis and signalingQ28282959
The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicansQ28473928
Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collectionQ28475711
Functional genomic analysis of C. elegans chromosome I by systematic RNA interferenceQ29547812
Protein modification by SUMOQ29547919
The diverse functions of histone lysine methylationQ29614523
The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stressesQ29616169
Mechanisms of specificity in protein phosphorylationQ29617541
Building ubiquitin chains: E2 enzymes at workQ29619578
Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclinsQ29620238
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradationQ29622825
Reading protein modifications with interaction domainsQ29622877
Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugationQ30857842
Molecular cloning and characterization of the Candida albicans UBI3 gene coding for a ubiquitin-hybrid proteinQ30952180
Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeastQ33386002
GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeatsQ36736572
Chromatin challenges during DNA replication and repairQ36744476
Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids.Q36759924
Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulenceQ36787424
Methylation of proteins involved in translationQ36870123
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review seriesQ36946992
Lipid remodeling of GPI-anchored proteins and its functionQ36959266
Protein-O-mannosyltransferases in virulence and developmentQ36988163
Stationary phase in the yeast Saccharomyces cerevisiaeQ37059288
Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein.Q37099390
Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathwaysQ37301922
Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi.Q37537816
Tasting the fungal cell wallQ37756214
Fine regulation of Saccharomyces cerevisiae MAPK pathways by post-translational modifications.Q37773859
Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies its activity during acquired thermotholeranceQ38343560
Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregationQ39449792
HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1.Q39497122
Morphogenesis, adhesive properties, and antifungal resistance depend on the Pmt6 protein mannosyltransferase in the fungal pathogen candida albicansQ39499662
Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitisQ39669355
NEDD8 recruits E2-ubiquitin to SCF E3 ligase.Q39731260
Proteinases, proteolysis and biological control in the yeast Saccharomyces cerevisiaeQ39845149
Grr1-dependent inactivation of Mth1 mediates glucose-induced dissociation of Rgt1 from HXT gene promotersQ39855161
Identification and characterization of a Candida albicans mating pheromoneQ40172519
Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeastQ40430046
Ubc9 is essential for viability of higher eukaryotic cellsQ40692747
The role of heat-shock proteins in thermotoleranceQ40709983
Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle programQ40908837
The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vitalQ41077782
The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiaeQ41125176
Acetylation of general transcription factors by histone acetyltransferasesQ41586010
Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans.Q41864652
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteinsQ41943542
Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicansQ42074010
Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.Q42144146
Global analysis of protein sumoylation in Saccharomyces cerevisiaeQ42466529
Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae).Q42501196
Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo.Q42609853
Glucose promotes stress resistance in the fungal pathogen Candida albicans.Q42636549
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiaeQ42642323
In silicio identification of glycosyl-phosphatidylinositol-anchored plasma-membrane and cell wall proteins of Saccharomyces cerevisiaeQ42670968
Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexesQ42850451
Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stressesQ42931443
The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphataseQ43049904
Integration of transcriptional and posttranslational regulation in a glucose signal transduction pathway in Saccharomyces cerevisiaeQ43196958
Characterization of the PMT gene family in Cryptococcus neoformansQ33487159
Candida albicans RIM101 pH response pathway is required for host-pathogen interactionsQ33592905
Ras signaling is required for serum-induced hyphal differentiation in Candida albicans.Q33637947
How the cyclin became a cyclin: regulated proteolysis in the cell cycleQ33641413
Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis.Q33667782
Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteinsQ33689010
Regulatory networks controlling Candida albicans morphogenesisQ33702252
Septins: cytoskeletal polymers or signalling GTPases?Q33730378
A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions.Q33782528
Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicansQ33808815
Proteolysis and the cell cycle: with this RING I do thee destroyQ33840470
Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesisQ33841398
Recent advances in the study of prenylated proteinsQ33889074
Septin function in Candida albicans morphogenesis.Q33902950
Ubiquitin-mediated proteolysis: biological regulation via destructionQ33910576
The regulation of protein function by multisite phosphorylation--a 25 year updateQ33928103
Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferasesQ33946702
The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicansQ33996677
Nalpha -terminal acetylation of eukaryotic proteinsQ34050317
Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the hostQ34055174
Regulation of gene expression by transcription factor acetylationQ34058501
The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificityQ34185745
Histone acetylation and deacetylation in yeastQ34187792
The ALS gene family of Candida albicansQ34207790
Transferable domain in the G(1) cyclin Cln2 sufficient to switch degradation of Sic1 from the E3 ubiquitin ligase SCF(Cdc4) to SCF(Grr1).Q34282128
Ubiquitin enters the new millenniumQ34388963
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.Q34433751
Sumoylation in Aspergillus nidulans: sumO inactivation, overexpression and live-cell imagingQ34454789
Molecular organization of the cell wall of Candida albicansQ34500159
Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicansQ34544362
Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicansQ34886777
Protein O-mannosylation: conserved from bacteria to humansQ34980261
Proteolysis and the cell cycleQ34995618
The F-Box Protein Fbp1 Regulates Sexual Reproduction and Virulence in Cryptococcus neoformansQ35080879
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectSCF E3 ubiquitin ligase complex F-box protein grrAQ62652120
P304page(s)98-108
P577publication date2011-12-09
P1433published inEukaryotic CellQ5408685
P1476titlePosttranslational modifications of proteins in the pathobiology of medically relevant fungi
P478volume11

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