The diverse functions of histone lysine methylation

scientific article (publication date: November 2005)

The diverse functions of histone lysine methylation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1028604901
P356DOI10.1038/NRM1761
P3181OpenCitations bibliographic resource ID892026
P698PubMed publication ID16261189

P2093author name stringMartin C
Zhang Y
P2860cites workTwo RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs.Q55039785
JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2βQ57024942
Imprinted X inactivation maintained by a mouse Polycomb group geneQ63407354
Trans-tail histone modifications: wedge or bridge?Q74531271
Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivationQ80918747
Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombinationQ80987684
Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31Q22009388
Structure and ligand of a histone acetyltransferase bromodomainQ22009928
DNA methylation patterns and epigenetic memoryQ22065780
Translating the Histone CodeQ22065840
The role of heterochromatin in centromere functionQ22065919
Regulation of chromatin structure by site-specific histone H3 methyltransferasesQ24290115
Histone deimination antagonizes arginine methylationQ24302163
Specificity and mechanism of the histone methyltransferase Pr-Set7.Q24304412
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activityQ24305075
Role of histone H2A ubiquitination in Polycomb silencingQ24305090
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.Q35804605
SAGA unveiled.Q36011032
The key to development: interpreting the histone code?Q36083253
Reversing histone methylationQ36240192
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.Q37592817
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeastQ39895202
Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3.Q40101766
Methylation: lost in hydroxylation?Q40110203
Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatinQ40390690
A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1.Q40544690
Hierarchical recruitment of polycomb group silencing complexesQ40549661
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryoteQ40903819
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosisQ41078460
A histone H3 methyltransferase controls DNA methylation in Neurospora crassaQ42664087
Intergenic transcription through a polycomb group response element counteracts silencingQ42705685
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.Q44094473
Establishment and maintenance of a heterochromatin domainQ44128134
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexesQ44399619
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatinQ44668068
HP1 is essential for DNA methylation in neurosporaQ44766530
Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3.Q44766533
Yeast heterochromatin: regulation of its assembly and inheritance by histonesQ46673607
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.Q52086106
The core histone N termini function independently of linker histones during chromatin condensation.Q52540827
Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila.Q52563488
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.Q53659407
Human PAD4 regulates histone arginine methylation levels via demethyliminationQ28280359
RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencingQ28287265
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaksQ28291639
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiaeQ28343956
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivationQ28505166
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylationQ28508260
Genome imprinting regulated by the mouse Polycomb group protein EedQ28510758
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9Q28594945
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domainQ28609769
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domainsQ28609779
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3Q28609869
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatinQ28647369
Active genes are tri-methylated at K4 of histone H3Q29547668
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activityQ29555842
Genomic maps and comparative analysis of histone modifications in human and mouseQ29614418
Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteinsQ29614507
Role of histone H3 lysine 27 methylation in X inactivationQ29614508
Partitioning and plasticity of repressive histone methylation states in mammalian chromatinQ29614513
The polycomb group protein EZH2 is involved in progression of prostate cancerQ29614514
Genome-wide map of nucleosome acetylation and methylation in yeastQ29614525
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate developmentQ29614526
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damageQ29614528
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase IIQ29614679
Methylation of histone H3 Lys 4 in coding regions of active genesQ29614680
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assemblyQ29614718
Dot1p modulates silencing in yeast by methylation of the nucleosome coreQ29614855
Histone methyltransferase activity of a Drosophila Polycomb group repressor complexQ29615394
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sitesQ29615395
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeastQ29617217
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferaseQ29617298
Arginine methylation an emerging regulator of protein functionQ29617311
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosomeQ29618064
Rb targets histone H3 methylation and HP1 to promotersQ29620452
Gene silencing: trans-histone regulatory pathway in chromatinQ30309681
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.Q31093400
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.Q33195734
Stabilization of chromatin structure by PRC1, a Polycomb complexQ33868583
The HP1 protein family: getting a grip on chromatinQ33885013
Histone modifications: combinatorial complexity or cumulative simplicity?Q33936701
Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domainsQ33937210
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOFQ24305335
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcriptionQ24312958
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1Q24336747
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3Q24531253
A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cellsQ24535932
RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA productionQ24557548
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatinQ24561636
RNAi-mediated targeting of heterochromatin by the RITS complexQ24623437
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27Q24672052
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesisQ24673923
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein associationQ24675122
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinQ24682617
Structure and function of a human TAFII250 double bromodomain moduleQ27622657
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomainsQ27641772
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteinsQ27860456
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domainQ27860477
The language of covalent histone modificationsQ27860931
Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B.Q27930655
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.Q27933975
hDOT1L links histone methylation to leukemogenesisQ27935809
BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complexQ27936121
Histone H2B ubiquitylation is associated with elongating RNA polymerase IIQ27936299
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylationQ27937996
Role of histone H3 lysine 27 methylation in Polycomb-group silencingQ28131795
Histone acetylation and an epigenetic codeQ28143767
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatinQ28187783
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repressionQ28208422
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tailsQ28216534
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAiQ28218870
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylationQ28265681
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complexQ28269256
Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assemblyQ28278522
Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functionsQ33958912
Recent advances in X-chromosome inactivationQ33978322
The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexesQ34059541
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Q34133875
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferaseQ34139275
cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic siteQ34152857
The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.Q34168365
Histone acetylation and deacetylation in yeastQ34187792
Epigenetic dynamics of imprinted X inactivation during early mouse developmentQ34283114
Role of protein methylation in chromatin remodeling and transcriptional regulationQ34290239
Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.Q34363546
Heterochromatin and gene expression in DrosophilaQ34399199
Histone methylation: dynamic or static?Q34731355
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegationQ34762156
An epigenetic road map for histone lysine methylationQ35120983
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)838-49
P577publication date2005-11-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleThe diverse functions of histone lysine methylation
P478volume6

Reverse relations

cites work (P2860)
Q39689810(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators
Q3568022115-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
Q45341627A Common histone modification code on C4 genes in maize and its conservation in Sorghum and Setaria italica
Q57267592A Fluorescence-Based Supramolecular Tandem Assay for Monitoring Lysine Methyltransferase Activity in Homogeneous Solution
Q55263249A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.
Q24635322A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Q35148553A chemical proteomics approach for global analysis of lysine monomethylome profiling.
Q91838839A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells
Q39430077A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
Q34990282A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs
Q53614800A convenient preparation of N (ε)-methyl-L-lysine derivatives and its application to the synthesis of histone tail peptides.
Q36340686A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases.
Q34875163A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation
Q56741581A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation
Q28588834A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9
Q33656610A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response
Q42208568A method to site-specifically introduce methyllysine into proteins in E. coli
Q64059241A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair
Q34342916A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Q30179453A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
Q36418916A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.
Q33799865A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.
Q36832683A prototypic lysine methyltransferase 4 from archaea with degenerate sequence specificity methylates chromatin proteins Sul7d and Cren7 in different patterns
Q42177453A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.
Q28480471A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin
Q35061395A silent exonic SNP in kdm3a affects nucleic acids structure but does not regulate experimental autoimmune encephalomyelitis
Q42203930A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases
Q34317299ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1
Q33930114AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function
Q36857675Ab initio quantum mechanical/molecular mechanical molecular dynamics simulation of enzyme catalysis: the case of histone lysine methyltransferase SET7/9.
Q34467617Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3).
Q41553016Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets
Q38437018Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins
Q36082540Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
Q57037529Activin/Smad2 and Wnt/β-catenin upregulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human ESCs
Q26770921Advances in Fmoc solid-phase peptide synthesis
Q24312056Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression
Q53669566Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM.
Q38431759Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era.
Q41379003An Ash1-Like Protein MoKMT2H Null Mutant Is Delayed for Conidium Germination and Pathogenesis in Magnaporthe oryzae
Q34478447An Emerging Role for Epigenetic Dysregulation in Arsenic Toxicity and Carcinogenesis
Q31166298An HMM approach to genome-wide identification of differential histone modification sites from ChIP-seq data
Q37401076An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
Q42907860An epigenetic clue to diabetic vascular disease
Q28539276An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors
Q37198810An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors
Q100316542An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease
Q36515764An investigation of heterochromatin domains on the fourth chromosome of Drosophila melanogaster
Q34341058An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1
Q24306384Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation
Q33316263Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays
Q33573969Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages
Q42172387Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state.
Q53586883Arabidopsis NRP1 and NRP2 encode histone chaperones and are required for maintaining postembryonic root growth.
Q51975694Arabidopsis relatives of the human lysine-specific Demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition.
Q34694111Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
Q34336449Association between genetic variants in DNA and histone methylation and telomere length
Q33719427Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor
Q79736562B chromosomes of B. dichromosomatica show a reduced level of euchromatic histone H3 methylation marks
Q24323889BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response
Q37884615BDNF-TrkB signalling in fear learning: from genetics to neural networks
Q35063368BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production
Q90623316BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses
Q39179169Beyond histones - the expanding roles of protein lysine methylation
Q38842748Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage.
Q61829990Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer
Q36752292Biology of polycomb and trithorax group proteins
Q40510451Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine
Q93108880Bone Remodeling: Histone Modifications as Fate Determinants of Bone Cell Differentiation
Q36318756C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association.
Q53689778C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation.
Q28116047C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the golgi and the midbody
Q52313097CTCF-KDM4A complex correlates with histone modifications that negatively regulate CHD5 gene expression in cancer cell lines.
Q35844494Cancer epigenetics: above and beyond
Q36871595Cancer genetics of epigenetic genes
Q42738357Cell cycle control by a methylation-phosphorylation switch
Q38214442Cell cycle progression in response to oxygen levels.
Q91668972Cell-Wide Survey of Amide-Bonded Lysine Modifications by Using Deacetylase CobB
Q38012873Cellular senescence: a double-edged sword in the fight against cancer
Q84293240Centromere inactivation and epigenetic modifications of a plant chromosome with three functional centromeres
Q36421082Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle
Q37600033ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients
Q38836957Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells.
Q34146751Changes in global histone modifications during dedifferentiation in newt lens regeneration
Q33754539Changes in histone H3 lysine 36 methylation in porcine oocytes and preimplantation embryos.
Q38319402Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage
Q36676505Characterization of Drosophila melanogaster JmjC+N histone demethylases.
Q46100977Characterization of Eu- and heterochromatin of citrus with a focus on the condensation behavior of 45S rDNA chromatin
Q41818257Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies
Q37832337Chatting histone modifications in mammals
Q40343286Chemical answers to epigenetic crosstalk.
Q36358096Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins.
Q37272504Chemical probes for histone-modifying enzymes
Q26829218Chemical probes of histone lysine methyltransferases
Q47097128Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins
Q30492487Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene
Q47970294Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9.
Q38007360Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm
Q33881683Chromatin environment of histone variant H3.3 revealed by quantitative imaging and genome-scale chromatin and DNA immunoprecipitation.
Q36968344Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells
Q34169989Chromatin modifying agents in the in vitro production of bovine embryos
Q48112864Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunction
Q37726329Chromatin remodeling and nuclear receptor signaling.
Q43247034Chromatin ultrastructural abnormalities in leukocytes, as peripheral markers of bipolar patients
Q37299868Chromatin: linking structure and function in the nucleolus
Q35945350Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram
Q46719180Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta
Q49148462Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer
Q34049138Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 fromSaccharomyces cerevisiae
Q39328444Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model
Q35017822Combinatorial chromatin modification patterns in the human genome revealed by subspace clustering.
Q40053196Combinatorial effects of four histone modifications in transcription and differentiation
Q50584847Comparative analysis of neural differentiation potential in human mesenchymal stem cells derived from chorion and adult bone marrow
Q33530669Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
Q41203218Comparative epigenetic influence of autologous versus fetal bovine serum on mesenchymal stem cells through in vitro osteogenic and adipogenic differentiation
Q41517520Compartmentation of metabolites in regulating epigenome of cancer
Q27936839Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome
Q46288028Computational characterization of substrate and product specificities, and functionality of S-adenosylmethionine binding pocket in histone lysine methyltransferases from Arabidopsis, rice and maize
Q55120002Computer-Aided Drug Design in Epigenetics.
Q26995268Concise review: Leukemia stem cells in personalized medicine
Q33857851Conservation in first introns is positively associated with the number of exons within genes and the presence of regulatory epigenetic signals
Q37243729Continuous enzymatic assay for histone lysine methyltransferases
Q24300761Contribution of H3K4 methylation by SET‐1A to interleukin‐1–induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes
Q37275279Controlling histone methylation via trans-histone pathways
Q47729663Controlling the supramolecular assembly of nucleosomes asymmetrically modified on H4.
Q57808630Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications
Q39182810Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity
Q33356481Core pathways controlling shoot meristem maintenance
Q37099890Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system
Q35767449CpG array analysis of histone H3 lysine 4 trimethylation by chromatin immunoprecipitation linked to microarrays analysis in peripheral blood mononuclear cells of IgA nephropathy patients
Q51984669Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.
Q47122605Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes
Q59268020Crucial function of histone lysine methylation in plant reproduction
Q49485495Crystal structure and mechanism of human lysine-specific demethylase-1.
Q35080371Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Q27665733Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
Q27674576Crystal structure of the human PRMT5:MEP50 complex
Q27646391Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
Q27688088Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2
Q35150331Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B
Q26795714DNA methylation pathways and their crosstalk with histone methylation
Q104794067DNA methyltransferase inhibitors modulate histone methylation: epigenetic crosstalk between H3K4me3 and DNA methylation during sperm differentiation
Q52729540DOT1L and H3K79 Methylation in Transcription and Genomic Stability.
Q34557154DOT1L regulates dystrophin expression and is critical for cardiac function
Q35083276DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
Q58749027DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells
Q58699717Deciphering and engineering chromodomain-methyllysine peptide recognition
Q27680120Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation
Q37424350Degrees make all the difference: the multifunctionality of histone H4 lysine 20 methylation
Q42291306Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c
Q43470464Demethylation of epiregulin gene by histone demethylase FBXL11 and BCL6 corepressor inhibits osteo/dentinogenic differentiation
Q27935305Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?
Q35774711Dendritic cells and aging: consequences for autoimmunity
Q36616276Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27.
Q43241839Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells
Q37113747Design of highly stabilized beta-hairpin peptides through cation-pi interactions of lysine and n-methyllysine with an aromatic pocket
Q26850027Design of small molecule epigenetic modulators
Q35215986Development and mechanistic studies of an optimized receptor for trimethyllysine using iterative redesign by dynamic combinatorial chemistry
Q42716358Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens
Q22306162Developmental roles of the histone lysine demethylases
Q37240185Developmental timing of the effects of maternal care on gene expression and epigenetic regulation of hormone receptor levels in female rats
Q36483376Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana
Q41915130Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage
Q92130384Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network
Q35016232Different Polycomb group complexes regulate common target genes in Arabidopsis.
Q38469502Differential lncRNA expression profiles in brown and white adipose tissues
Q52567256Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis.
Q36523796Digging deep into "dirty" drugs - modulation of the methylation machinery
Q41777011Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub.
Q27684229Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Q48298211Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
Q27658070Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Q28244062Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8
Q37432733Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
Q33663034Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals
Q35641861Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences
Q36339151Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies
Q33285707Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing
Q39147680Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family
Q37976277Diversity within the pRb pathway: is there a code of conduct?
Q37822707Double-strand breaks and the concept of short- and long-term epigenetic memory.
Q37346666Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells
Q50785751Drosophila LSD1-CoREST demethylase complex regulates DPP/TGFβ signaling during wing development
Q33284535Drosophila SETDB1 is required for chromosome 4 silencing
Q37965165Drug discovery toward antagonists of methyl-lysine binding proteins
Q35562632Dual functions of histone-lysine N-methyltransferase Setdb1 protein at promyelocytic leukemia-nuclear body (PML-NB): maintaining PML-NB structure and regulating the expression of its associated genes
Q46120564Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle.
Q37829706Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".
Q64230085Dynamic patterns of H3K4me3, H3K27me3, and Nanog during rabbit embryo development
Q34857637Dynamic protein methylation in chromatin biology
Q34057709Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq
Q35071278Dynamic regulation of histone modifications in Xenopus oocytes through histone exchange
Q37831766Dynamics of epigenetic modifications in leukemia
Q34620820Dynamics of histone lysine methylation: structures of methyl writers and erasers
Q38975402Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?
Q40730252E3-Independent Constitutive Monoubiquitination Complements Histone Methyltransferase Activity of SETDB1.
Q34109344EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.
Q24645960EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
Q48035326Early Life Exposure to Low Levels of AHR Agonist PCB126 (3,3',4,4',5-Pentachlorobiphenyl) Reprograms Gene Expression in Adult Brain
Q47341920Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline
Q93017032Effect of Long-Term Fungicide Applications on Virulence and Diversity of Colletotrichum spp. Associated to Olive Anthracnose
Q39588955Effects of DNA methylation and histone modification on differentiation-associated gene expression in ES, NIH3T3, and NIT-1.
Q34521055Effects of Prenatal Testosterone Exposure on Sexually Dimorphic Gene Expression in the Neonatal Mouse Cortex and Hippocampus
Q35549668Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro
Q41072068Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells
Q50161431Effects of histone methyltransferase inhibition in endometriosis.
Q33859407Effects of nickel treatment on H3K4 trimethylation and gene expression
Q37199069Effects of nickel, chromate, and arsenite on histone 3 lysine methylation
Q36409211Effects of siRNA-mediated knockdown of jumonji domain containing 2A on proliferation, migration and invasion of the human breast cancer cell line MCF-7
Q34046987Efficient hit-finding approaches for histone methyltransferases: the key parameters
Q47224379Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.
Q37455875Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.
Q39294162Emerging roles for histone modifications in DNA excision repair
Q38557842Emerging roles of lysine methylation on non-histone proteins
Q34978408Emerging roles of post-translational modifications in signal transduction and angiogenesis
Q55418713Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis.
Q58049788Endothelial Transcriptome in Response to Pharmacological Methyltransferase Inhibition
Q34237731Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1.
Q46236277Enhancer requirement for histone methylation linked with gene activation
Q28397621Environmental chemical exposures and human epigenetics
Q52317267Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation.
Q26859263Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications
Q90484556Epigenetic Control of Mitochondrial Function in the Vasculature
Q28579049Epigenetic Histone Methylation Modulates Fibrotic Gene Expression
Q38946328Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy
Q56501909Epigenetic Mechanisms of Mental Retardation
Q64263723Epigenetic Modifications in Alzheimer's Neuropathology and Therapeutics
Q36103311Epigenetic Modulation of Human Podocyte Vitamin D Receptor in HIV Milieu
Q34897761Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer.
Q26743597Epigenetic Regulation of Oxidative Stress in Ischemic Stroke
Q33802356Epigenetic Targeting of Transforming Growth Factor β Receptor II and Implications for Cancer Therapy
Q36177524Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation
Q24625376Epigenetic alterations in aging
Q37401725Epigenetic aspects in carcinomas of the head and neck
Q38080554Epigenetic changes in diabetes.
Q34413567Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
Q33758067Epigenetic characteristics of the mitotic chromosome in 1D and 3D.
Q46243255Epigenetic considerations in aquaculture
Q34066178Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors
Q53335869Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.
Q46814464Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons
Q38039303Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis
Q37756526Epigenetic control of neural precursor cell fate during development
Q34485800Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms.
Q42726445Epigenetic effects of ethanol on liver and gastrointestinal injury
Q34605996Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice
Q36752495Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes
Q44858633Epigenetic histone methylation regulates transforming growth factor β-1 expression following bile duct ligation in rats.
Q38072984Epigenetic mechanisms and endocannabinoid signalling.
Q26827394Epigenetic mechanisms in experience-driven memory formation and behavior
Q38296760Epigenetic mechanisms of breast cancer: an update of the current knowledge
Q28238273Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene
Q37887378Epigenetic mechanisms.
Q27693287Epigenetic modifications: basic mechanisms and role in cardiovascular disease.
Q38024759Epigenetic programming and risk: the birthplace of cardiovascular disease?
Q37976256Epigenetic regulation in RCC: opportunities for therapeutic intervention?
Q37962589Epigenetic regulation of HIV-1 transcription
Q36997510Epigenetic regulation of LSD1 during mammary carcinogenesis
Q34176762Epigenetic regulation of adipocyte differentiation and adipogenesis
Q36445801Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response
Q33764436Epigenetic regulation of epithelial-mesenchymal transition
Q27025037Epigenetic regulation of inducible gene expression in the immune system
Q35109954Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation
Q37890242Epigenetic regulation of pulmonary arterial hypertension
Q35921631Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1.
Q39687107Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer
Q37714772Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma
Q37802749Epigenetic regulations in hematopoietic Hox code.
Q36891904Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island
Q40103534Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance
Q37386440Epigenetic targets for reversing immune defects caused by alcohol exposure
Q38219414Epigenetic-based therapies for Friedreich ataxia
Q38019955Epigenetics and blood disorders
Q27023846Epigenetics and the control of the collecting duct epithelial sodium channel
Q38153255Epigenetics components of aging in the central nervous system.
Q36663928Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy
Q26991779Epigenetics in breast cancer: what's new?
Q90667761Epigenetics in ovarian cancer: premise, properties, and perspectives
Q35608952Epigenetics in prostate cancer
Q37200532Epigenetics of diabetic complications
Q42030420Epigenetics: Tools and Technologies
Q35068854Epigenetics: deciphering its role in diabetes and its chronic complications
Q28083951Epigenome-based personalized medicine in human cancer
Q37078784Epigenomics and breast cancer
Q35636575Epigenomics and ovarian carcinoma.
Q26823403Epigenomics of leukemia: from mechanisms to therapeutic applications
Q47372409Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function
Q38292386Essential role of C/EBPalpha in G-CSF-induced transcriptional activation and chromatin modification of myeloid-specific genes
Q42904699Essential role of DOT1L in maintaining normal adult hematopoiesis.
Q90430690Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing
Q39728608Establishment and characterization of multi-drug resistant, prostate carcinoma-initiating stem-like cells from human prostate cancer cell lines 22RV1.
Q36659540Eukaryotic DNA replication in a chromatin context
Q37715576Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes.
Q37015377Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta.
Q43125466Evolutionary conservation levels of subunits of histone-modifying protein complexes in fungi
Q33379270Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence
Q37785980Evolutionary origin of the cell nucleus and its functional architecture.
Q89947930Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
Q34517459Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects
Q38245426Expanded genetic code technologies for incorporating modified lysine at multiple sites
Q42819548Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling
Q35658900Expansion and Functional Divergence of Jumonji C-Containing Histone Demethylases: Significance of Duplications in Ancestral Angiosperms and Vertebrates
Q53048996Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin.
Q42256259Extensive lysine methylation in hyperthermophilic crenarchaea: potential implications for protein stability and recombinant enzymes
Q92155695Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression
Q26995083Extracellular-vesicle type of volume transmission and tunnelling-nanotube type of wiring transmission add a new dimension to brain neuro-glial networks
Q35624706FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.
Q24336380Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly
Q91728282Fine-tuning AKT kinase activity through direct lysine methylation
Q33779188Fine-tuning of epigenetic regulation with respect to promoter CpG content in a cell type-specific manner
Q38832210First Comprehensive Proteome Analyses of Lysine Acetylation and Succinylation in Seedling Leaves of Brachypodium distachyon L.
Q36579359Five repair pathways in one context: chromatin modification during DNA repair
Q33558438Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription
Q46817449Formation of epsilon-formyllysine on silver-stained proteins: implications for assignment of isobaric dimethylation sites by tandem mass spectrometry
Q26781247Functional Role of G9a Histone Methyltransferase in Cancer
Q36315263Functional analysis of the transcription repressor PLU-1/JARID1B.
Q41555305Functional antagonism between histone H3K4 demethylases in vivo
Q38615077Functional coupling between writers, erasers and readers of histone and DNA methylation
Q28570357G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation
Q90618258Gene editing and CRISPR in the clinic: current and future perspectives
Q33697209Gene expression in the placenta: maternal stress and epigenetic responses
Q40048569Gene expression under thermal stress varies across a geographical range expansion front
Q38121941Gene regulation and epigenetics in Friedreich's ataxia
Q39216552Genetic and Epigenetic Regulation of CCR5 Transcription
Q37051825Genetic and molecular control of osterix in skeletal formation
Q37267318Genetics and epigenetics of arrhythmia and heart failure
Q39540389Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by High-Throughput Sequencing.
Q46097620Genome-wide analysis of histone H3 lysine 27 trimethylation by ChIP-chip in gastric cancer patients.
Q51038061Genome-wide analysis of histone H3 lysine9 trimethylation by ChIP-seq in peripheral blood mononuclear cells of uremia patients.
Q36567360Genome-wide patterns of histone modifications in yeast.
Q35251281Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns
Q41864428Genome-wide screen of human bromodomain-containing proteins identifies Cecr2 as a novel DNA damage response protein
Q35745024Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1
Q21562301Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes
Q33463262Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes
Q21263183Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins
Q88540298Gestational Hypoxia and Developmental Plasticity
Q47438320Global Proteome Analysis Links Lysine Acetylation to Diverse Functions in Oryza Sativa
Q42495438Global Regulation of Plant Immunity by Histone Lysine Methyl Transferases.
Q39646089Global and gene-specific histone modification profiles of mouse multipotent adult germline stem cells
Q36149209Global heterochromatin loss: a unifying theory of aging?
Q24336253Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes
Q47139599H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Q46420549H3K23me1 is an evolutionarily conserved histone modification associated with CG DNA methylation in Arabidopsis.
Q52776735H3K79 methylation directly precedes the histone-to-protamine transition in mammalian spermatids and is sensitive to bacterial infections.
Q33641829H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability
Q33722642H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation
Q34780858HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination
Q41992090HDAC4 controls histone methylation in response to elevated cardiac load
Q28290352HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics
Q45314189HDMs demethylate histones
Q39322982HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism
Q36520900HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells
Q37737514HP1: heterochromatin binding proteins working the genome
Q88683326HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A
Q36770275Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate
Q34413666Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network
Q33422980Heterochromatic genome stability requires regulators of histone H3 K9 methylation
Q33427858Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells
Q37097790Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase
Q29614716Heterochromatin revisited
Q37257338Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo
Q39329719High levels of glucose induce "metabolic memory" in cardiomyocyte via epigenetic histone H3 lysine 9 methylation
Q27654666High-Affinity Binding of Chp1 Chromodomain to K9 Methylated Histone H3 Is Required to Establish Centromeric Heterochromatin
Q54547285High-resolution mapping of epigenetic modifications of the rice genome uncovers interplay between DNA methylation, histone methylation, and gene expression.
Q26851462High-throughput screening to identify inhibitors of lysine demethylases
Q35917373Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast
Q64070328Histone 4 Lysine 20 Methylation: A Case for Neurodevelopmental Disease
Q53300920Histone Demethylase JARID1B is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression Via Demethylation of H3K27me3.
Q34822197Histone Demethylases in Colon Cancer
Q46913032Histone H3 Arg2 methylation provides alternative directions for COMPASS.
Q36942424Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4
Q42229711Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.
Q37534478Histone H3 Methyltransferase Suv39h1 Prevents Myogenic Terminal Differentiation by Repressing MEF2 Activity in Muscle Cells
Q38409875Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression
Q64226348Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling
Q49679547Histone H3 lysine 9 methyltransferase FvDim5 regulates fungal development, pathogenicity and osmotic stress responses in Fusarium verticillioides
Q35195947Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin
Q39294157Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.
Q35577727Histone H3K9 modifications are a local chromatin event involved in ethanol-induced neuroadaptation of the NR2B gene
Q39066287Histone Lysine Demethylase Inhibitors.
Q39406947Histone Lysine Methylation and Neurodevelopmental Disorders
Q36924772Histone Lysine Methylation in TGF-β1 Mediated p21 Gene Expression in Rat Mesangial Cells.
Q90061993Histone Methylation Participates in Gene Expression Control during the Early Development of the Pacific Oyster Crassostrea gigas
Q37797706Histone Modification Therapy of Cancer
Q46488585Histone Modifications Define Expression Bias of Homoeologous Genomes in Allotetraploid Cotton
Q89605002Histone Modifying Enzymes and Chromatin Modifiers in Glioma Pathobiology and Therapy Responses
Q37878875Histone acetylation and its role in embryonic stem cell differentiation
Q29620006Histone acetyltransferase complexes: one size doesn't fit all
Q43092018Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion
Q36710904Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.
Q39652309Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10
Q34938177Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
Q34699020Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development
Q36471184Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
Q38909037Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism
Q24299384Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors
Q28589881Histone demethylase LSD1 regulates neural stem cell proliferation
Q28076257Histone demethylase lysine demethylase 5B in development and cancer
Q37898723Histone demethylases in chromatin cross-talks
Q27939224Histone demethylation by a family of JmjC domain-containing proteins
Q34451532Histone h4 modification during mouse spermatogenesis
Q38172162Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential
Q26799821Histone lysine demethylases in Drosophila melanogaster
Q38248614Histone lysine methylation in diabetic nephropathy
Q37962022Histone lysine methylation: an epigenetic modification?
Q36051466Histone lysine methyltransferases and demethylases in Plasmodium falciparum
Q38210943Histone methylation during neural development
Q55261726Histone methylation in DNA repair and clinical practice: new findings during the past 5-years.
Q37961859Histone methylation in myelodysplastic syndromes
Q47860333Histone methylation in the freeze-tolerant wood frog (Rana sylvatica).
Q35836643Histone methylation levels correlate with TGFBIp and extracellular matrix gene expression in normal and granular corneal dystrophy type 2 corneal fibroblasts
Q24632499Histone methylation regulates memory formation.
Q36014589Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors
Q35022234Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state
Q37497415Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells
Q37780469Histone methyltransferases: regulation of transcription and contribution to human disease
Q42798061Histone modification pattern of the T-cellular Herpesvirus saimiri genome in latency
Q34559303Histone modifications and chromatin organization in prostate cancer
Q24647743Histone modifications and nuclear architecture: a review
Q30908360Histone modifications are specifically relocated during gene activation and nuclear differentiation
Q54508771Histone modifications associated with both A and B chromosomes of maize.
Q42316676Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions
Q36114870Histone post-translational modifications in frontal cortex from human donors with Alzheimer's disease.
Q35944771Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3
Q24545952Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
Q35229609Histones: at the crossroads of peptide and protein chemistry
Q29547350How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Q37091575How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations
Q24300752Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria
Q27683647Human UTY(KDM6C) Is a Male-specific N -Methyl Lysyl Demethylase
Q34155688Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer
Q39041123Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy.
Q48225818Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer.
Q36593766Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
Q34430188Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
Q30279300Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP)
Q35901931Hypoxia-induced and stress-specific changes in chromatin structure and function
Q96162658IL-10 promotes malignant pleural effusion by regulating TH 1 response via a miR-7116-5p/GPR55/ERK pathway in mice
Q40333502Identification and Analysis of the SET-Domain Family in Silkworm, Bombyx mori
Q42358298Identification and characterization of PKF118-310 as a KDM4A inhibitor
Q28505248Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
Q35880093Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation
Q24299989Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex
Q35173191Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach
Q64075443Identification of Two Novel Mutations in KDM3A Regulatory Gene in Iranian Infertile Males
Q28484041Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain
Q34971229Identification of estrogen receptor-related receptor gamma as a direct transcriptional target of angiogenin
Q27939452Identification of histone demethylases in Saccharomyces cerevisiae.
Q28476731Identification of lysine 37 of histone H2B as a novel site of methylation
Q92476130Identification of lysine methylation in the core GTPase domain by GoMADScan
Q34154612Identification of lysine succinylation as a new post-translational modification
Q34073864Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.
Q49106909Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide
Q41428742Identifying novel proteins recognizing histone modifications using peptide pull-down assay
Q42398073Identifying the combinatorial effects of histone modifications by association rule mining in yeast
Q34527766Implications of prenatal steroid perturbations for neurodevelopment, behavior, and autism
Q34845922Imprinting disorders and assisted reproductive technology
Q50062451Improving succinylation prediction accuracy by incorporating the secondary structure via helix, strand and coil, and evolutionary information from profile bigrams.
Q33661504In vivo residue-specific histone methylation dynamics
Q28273291Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice
Q36957650Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis
Q64063180Increased Extracellular Matrix Protein Production in Chronic Diabetic Complications: Implications of Non-Coding RNAs
Q36804871Inferring causal relationships among different histone modifications and gene expression
Q36240807Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors
Q48700970Inhibition of G9a/GLP Complex Promotes Long-Term Potentiation and Synaptic Tagging/Capture in Hippocampal CA1 Pyramidal Neurons
Q47582238Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis.
Q35762084Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
Q38740496Inhibitors of Protein Methyltransferases and Demethylases.
Q38833038Inhibitors of enzymes catalyzing modifications to histone lysine residues: structure, function and activity
Q37340761Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
Q35028879Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells
Q36495170Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer
Q34628232Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells.
Q41851400Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe
Q39574967Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth.
Q36989015Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.
Q37724099Interferon-γ resets muscle cell fate by stimulating the sequential recruitment of JARID2 and PRC2 to promoters to repress myogenesis
Q37797693Interplay Between Different Epigenetic Modifications and Mechanisms
Q24310370Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein
Q36788865Intersection of nuclear receptors and the proteasome on the epigenetic landscape
Q35553256Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics
Q39768084Investigation of H2AX methylation by the SUV39H2 protein lysine methyltransferase
Q39367421Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.
Q37110599Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation
Q39173734Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation
Q36579347Is histone loss a common feature of DNA metabolism regulation?
Q57568062Is the “Histone Code” an Organic Code?
Q35676840Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons
Q50010956Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Q40209070Isolation and characterization of histone H3 lysine 4 demethylase-containing complexes
Q34614892Isolation and characterization of proteins associated with histone H3 tails in vivo
Q79853386It takes a PHD to interpret histone methylation
Q39216883Iterative Fragmentation Improves the Detection of ChIP-seq Peaks for Inactive Histone Marks
Q64079033JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer
Q24315882JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor
Q35863331JMJ704 positively regulates rice defense response against Xanthomonas oryzae pv. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators
Q52680682JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress.
Q37437607JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression
Q96128253JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy
Q35127287JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice
Q64229851JmjC Domain-Encoding Genes Are Conserved in Highly Regenerative Metazoans and Are Associated with Planarian Whole-Body Regeneration
Q29614517JmjC-domain-containing proteins and histone demethylation
Q28253382Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
Q33594057Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis
Q36032226Joining the dots: from chromatin remodeling to neuronal plasticity
Q42152404KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.
Q36984826KDM1 is a novel therapeutic target for the treatment of gliomas
Q36370206KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice.
Q37384068KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.
Q49201007KDM2B overexpression correlates with poor prognosis and regulates glioma cell growth
Q39004536KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
Q48242753KDM6A promotes chondrogenic differentiation of periodontal ligament stem cells by demethylation of SOX9.
Q24301409KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development
Q53225237KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development.
Q35821188Kabuki syndrome genes KMT2D and KDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development
Q36219705Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.
Q24337427Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
Q57474446Knockdown of SETDB1 inhibits breast cancer progression by miR-381-3p-related regulation
Q33924539Late stage modification of receptors identified from dynamic combinatorial libraries
Q35568111Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation
Q57941519Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
Q27676706Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases
Q92405038Lnc-C/EBPβ Modulates Differentiation of MDSCs Through Downregulating IL4i1 With C/EBPβ LIP and WDR5
Q35018398Long non-coding RNA expression profiling of mouse testis during postnatal development
Q28472157Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation
Q35170918Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1
Q36695120Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome
Q35941514Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma
Q42399366Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1
Q50043702Lsd1 interacts with cMyb to demethylate repressive histone marks and maintain inner ear progenitor identity.
Q44998288Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark
Q91737447Lysine Ethylation by Histone Lysine Methyltransferases
Q47165835Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis.
Q38019558Lysine methylation and the regulation of p53.
Q38706561Lysine methylation of promoter-bound transcription factors and relevance to cancer
Q37970950Lysine methylation: beyond histones
Q34258578Lysine succinylation and lysine malonylation in histones.
Q34905762Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].
Q34085901MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output
Q36731942MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.
Q39781478MS/MS/MS reveals false positive identification of histone serine methylation
Q37524412Manipulating the epigenome for the treatment of urological malignancies
Q40042389Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics.
Q34998301Maternal depletion of Piwi, a component of the RNAi system, impacts heterochromatin formation in Drosophila
Q47785961Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring
Q91942288Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula
Q33643242MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
Q34974385MeMo: a web tool for prediction of protein methylation modifications.
Q35829019Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity
Q53606806Mechanisms of Evolutionary Innovation Point to Genetic Control Logic as the Key Difference Between Prokaryotes and Eukaryotes.
Q34323788Mechanisms of epigenetic memory and addiction
Q40130350Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia
Q38061846Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks.
Q36866040Mechanistic analysis of a suicide inactivator of histone demethylase LSD1
Q43200898Mediator subunits and histone methyltransferase Set2 contribute to Ino2-dependent transcriptional activation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae
Q36882963Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
Q36657938Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation
Q91656884Metabolic Plasticity and Epithelial-Mesenchymal Transition
Q91997323Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome
Q39173866Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus
Q39707338Methylation of ribosomal protein L42 regulates ribosomal function and stress-adapted cell growth
Q24300912Methylation of the retinoblastoma tumor suppressor by SMYD2
Q80167947Methyllysine analogs: rewriting the code
Q39036341Methyltransferase-Directed Labeling of Biomolecules and its Applications.
Q36175435Microvesicles/exosomes as potential novel biomarkers of metabolic diseases
Q38970543Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones
Q59314000Mining Massive Amounts of Genomic Data: A Semiparametric Topic Modeling Approach
Q37155394Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation
Q37332446Minireview: role of protein methylation and demethylation in nuclear hormone signaling.
Q34002132Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.
Q37175579Modern approaches for investigating epigenetic signaling pathways
Q52312877Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Q93015456Molecular basis for histidine N3-specific methylation of actin H73 by SETD3
Q28242466Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
Q42399228Molecular dynamics of β-hairpin models of epigenetic recognition motifs
Q42472280Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation
Q64097188Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Q100429985Molecular mechanisms of KDM5A in cellular functions: Facets during development and disease
Q36177449Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin
Q30443104Multi-tasking on chromatin with the SAGA coactivator complexes
Q57893686Multiple Site-Specific Installations ofNε-Monomethyl-L-Lysine into Histone Proteins by Cell-Based and Cell-Free Protein Synthesis
Q48695210Multiple histone site epigenetic modifications in nuclear transfer and in vitro fertilized bovine embryos
Q36497987Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity
Q28299627Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development
Q26782506Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas
Q36324695Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease
Q24675749N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage
Q36088689NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression
Q33770536NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation
Q34124364Negative regulation of hypoxic responses via induced Reptin methylation.
Q35765094Neighboring Genes Show Correlated Evolution in Gene Expression
Q37598306New insights into molecular mechanisms of diabetic kidney disease
Q36890708Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases
Q34143826Notable epigenetic role of hyperhomocysteinemia in atherogenesis
Q38728613Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway
Q55317166Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia.
Q34925545Nuclear lamins and chromatin: when structure meets function.
Q34766646Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
Q35238314Nuclear reprogramming in mouse primordial germ cells: epigenetic contribution.
Q37727692Nucleic acid oxidation in DNA damage repair and epigenetics
Q34299252Nucleolar Follistatin Promotes Cancer Cell Survival under Glucose-deprived Conditions through Inhibiting Cellular rRNA Synthesis
Q42083099Nucleolin is required for RNA polymerase I transcription in vivo
Q37848613Nucleosomes in the neighborhood: new roles for chromatin modifications in replication origin control
Q28572838Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation
Q35023118Oncogenic features of PHF8 histone demethylase in esophageal squamous cell carcinoma
Q34072268Oocyte-type linker histone B4 is required for transdifferentiation of somatic cells in vivo
Q36744726Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C).
Q28295495Opposing LSD1 complexes function in developmental gene activation and repression programmes
Q24672606Opposing roles for Set2 and yFACT in regulating TBP binding at promoters
Q36210887Origins and formation of histone methylation across the human cell cycle.
Q34103537Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line
Q38380029Osterix and NO66 histone demethylase control the chromatin of Osterix target genes during osteoblast differentiation
Q33797181Over-expression of histone H3K4 demethylase gene JMJ15 enhances salt tolerance in Arabidopsis
Q43556258Overexpression of MMSET is correlation with poor prognosis in hepatocellular carcinoma
Q29248994Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy
Q34259740PLMLA: prediction of lysine methylation and lysine acetylation by combining multiple features
Q36010294PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential
Q33309162Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.
Q33963810Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors
Q34101030Phylogenetic analysis and classification of the Brassica rapa SET-domain protein family
Q34271529Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells
Q36826687Plant SET domain-containing proteins: structure, function and regulation
Q41911402Polyamine-based small molecule epigenetic modulators.
Q53080173Polycomb protein EZH2 expression in diffuse large B-cell lymphoma is associated with better prognosis in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone.
Q36465574Post-translational modifications of histones H3 and H4 associated with the histone methyltransferases Suv39h1 and G9a.
Q38232008Posttranslational modifications of human histone H3: an update
Q26824233Posttranslational modifications of proteins in the pathobiology of medically relevant fungi
Q48944259Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity.
Q36585568Preferential dimethylation of histone H4 lysine 20 by Suv4-20
Q81557015Primers on chromatin
Q46110457Processing the H3K36me3 signature
Q36082116Processive phosphorylation: mechanism and biological importance
Q36230208Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability
Q41077260Profile of histone lysine methylation across transcribed mammalian chromatin
Q42737853Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells
Q46294277Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus
Q57826141Prominent role of histone lysine demethylases in cancer epigenetics and therapy
Q24673598Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions
Q38271076Prostate cancer epigenome
Q38302162Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coli
Q38053799Protein and nucleic acid methylating enzymes: mechanisms and regulation
Q28567709Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF
Q36959982Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells
Q28486149Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation
Q34059822Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines
Q37606682Protein methylation and interaction with the antiproliferative gene, BTG2/TIS21/Pc3.
Q33580119Protein post-translational modifications: In silico prediction tools and molecular modeling
Q41295369Protein-protein-interaction network organization of the hypusine modification system
Q54613836Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.
Q36392924Proteome-wide profiling of protein lysine acetylation in Aspergillus flavus
Q36835605Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation
Q46186503Purification and characterization of a urea sensitive lactate dehydrogenase from the liver of the African clawed frog, Xenopus laevis
Q41985000Purification of histone demethylases from HeLa cells.
Q36073727Purification, crystallization and preliminary crystallographic analysis of histone lysine demethylase NO66 from Homo sapiens
Q56879313Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells
Q38321307QM/MM MD and free energy simulation study of methyl transfer processes catalyzed by PKMTs and PRMTs
Q34280128QM/MM MD and free energy simulations of G9a-like protein (GLP) and its mutants: understanding the factors that determine the product specificity
Q36163445Quantitative assessment of chromatin immunoprecipitation grade antibodies directed against histone modifications reveals patterns of co-occurring marks on histone protein molecules
Q30375585Quantitative proteomic analysis of histone modifications
Q37623626Quantitative proteomics reveals histone modifications in crosstalk with H3 lysine 27 methylation
Q28537878RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer
Q39696157RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma
Q35027747RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers
Q36181450Rapid Histone-Catalyzed DNA Lesion Excision and Accompanying Protein Modification in Nucleosomes and Nucleosome Core Particles
Q35156976Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes
Q89477891Recent Development of Genetic Code Expansion for Posttranslational Modification Studies
Q37522449Recent advances in the development of polyamine analogues as antitumor agents
Q38829039Recently discovered EZH2 and EHMT2 (G9a) inhibitors
Q36735246Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.
Q27665584Recognition and Specificity Determinants of the Human Cbx Chromodomains
Q24298348Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation
Q30443981Recognition of trimethyllysine by a chromodomain is not driven by the hydrophobic effect
Q37381316Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases
Q29614518Regulation of MLL1 H3K4 methyltransferase activity by its core components
Q37169910Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein
Q28513150Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin
Q24296401Regulation of cell cycle progression and gene expression by H2A deubiquitination
Q34606198Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.
Q28291841Regulation of histone methylation by demethylimination and demethylation
Q31001642Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor
Q24318629Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase
Q93051746Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis
Q33315270Removal of high-abundance proteins for nuclear subproteome studies in rice (Oryza sativa) endosperm
Q51747114Removal of histone tails from nucleosome dissects the physical mechanisms of salt-induced aggregation, linker histone H1-induced compaction, and 30-nm fiber formation of the nucleosome array.
Q36059543Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline
Q49724275Repression of Akt3 gene transcription by the tumor suppressor RIZ1.
Q34273293Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells
Q24315937Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases
Q38270780Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date
Q38895216Rewiring the solid tumor epigenome for cancer therapy
Q42414383Role of H3K27 methylation in the regulation of lncRNA expression
Q47748582Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms
Q41876713Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
Q39110529Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation
Q37769114Role of histone methylation and demethylation in adipogenesis and obesity.
Q38171673Role of miRNAs and epigenetics in neural stem cell fate determination
Q36639797Role of several histone lysine methyltransferases in tumor development
Q39957980Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation
Q37219745Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice
Q26999018Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
Q37726345Roles of histone H3-lysine 4 methyltransferase complexes in NR-mediated gene transcription.
Q36686379Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma
Q36484713Roles of jumonji and jumonji family genes in chromatin regulation and development
Q46698178Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.
Q27929974Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification
Q50013273S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life.
Q38062519S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.
Q50437679SET DOMAIN GROUP701 encodes a H3K4-methytransferase and regulates multiple key processes of rice plant development.
Q92180225SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients
Q41815704SET8-mediated methylations of histone H4 lysine 20 mark silent heterochromatic domains in apicomplexan genomes.
Q39007856SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis
Q33812604SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression.
Q35149495SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair
Q52757703SUMO, a small, but powerful, regulator of double-strand break repair.
Q34766981SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells
Q24294553Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4
Q35135783Selective inhibitors of protein methyltransferases
Q42288180Selective recognition of acetylated histones by bromodomains in transcriptional co-activators
Q99557417Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate
Q26828610Serine, glycine and one-carbon units: cancer metabolism in full circle
Q90750498Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction
Q44814485Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas
Q35886877Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer.
Q34657669Simultaneous mutation of methylated lysine residues in histone H3 causes enhanced gene silencing, cell cycle defects, and cell lethality in Saccharomyces cerevisiae
Q35707150Sirtuin 1: A Target for Kidney Diseases
Q91795691Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B
Q40052749Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells
Q39378020Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.
Q24324008Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4
Q57025483Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications
Q37016166Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development.
Q33637036Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses
Q93104286Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth
Q35533085Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock
Q34157702Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry
Q35651812Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy
Q38009768Stem cells: a view from the roots
Q48377058Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain
Q27649150Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger
Q27659033Structural Biology of Human H3K9 Methyltransferases
Q37941688Structural Chemistry of Human SET Domain Protein Methyltransferases
Q39543220Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia
Q27666725Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding
Q24669691Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
Q24314963Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5
Q27644954Structural basis of histone demethylation by LSD1 revealed by suicide inactivation
Q24310492Structural basis of the recognition of a methylated histone tail by JMJD2A
Q27676033Structural insight into substrate recognition by histone demethylase LSD2/KDM1b
Q42559891Structural insights into Rhino-mediated germline piRNA cluster formation
Q27662561Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Q34441278Structural insights into histone lysine demethylation
Q37104206Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy
Q21142735Structural studies of a four-MBT repeat protein MBTD1
Q27012506Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation
Q36015982Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8.
Q44888525Structure of the JmjC-domain-containing protein JMJD5.
Q88993597Structure-Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7
Q27675595Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b
Q46204578Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes
Q27684252Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives
Q55659123Structure–Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins.
Q27704244Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases
Q46907785Substrate preferences of the EZH2 histone methyltransferase complex.
Q35824823Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential
Q36478099Suppression and recovery of BRCA1-mediated transcription by HP1γ via modulation of promoter occupancy
Q40390762Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes.
Q56454444Supramolecular hosts that recognize methyllysines and disrupt the interaction between a modified histone tail and its epigenetic reader protein
Q27676661Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
Q92938922Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
Q51706302System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach.
Q47252056Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease
Q36853637T cell development: better living through chromatin
Q35555559TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development
Q59329659Tackling malignant melanoma epigenetically: histone lysine methylation
Q37221794Tackling the epigenome in the pluripotent stem cells
Q37709373Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development
Q93139190Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics
Q58830257Targeting the JMJD2A histone lysine demethylase
Q37941687Targets in epigenetics: inhibiting the methyl writers of the histone code
Q37384129Telomeres, histone code, and DNA damage response
Q64070147The Application of Cell-Free Protein Synthesis in Genetic Code Expansion for Post-translational Modifications
Q64066962The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor
Q38964467The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells
Q47372832The Dawn of Succinylation: A Posttranslational Modification
Q28821689The Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making
Q35130403The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development
Q41139971The Epigenetic Landscape of Promoter Genome-wide Analysis in Breast Cancer
Q28296070The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)
Q28305275The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3
Q36265655The Helicase Activity of Hyperthermophilic Archaeal MCM is Enhanced at High Temperatures by Lysine Methylation
Q35104140The Ino80 complex prevents invasion of euchromatin into silent chromatin
Q38330908The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene
Q24672128The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression
Q39801387The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene
Q35676279The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.
Q61809730The Oncogenic Potential of SUV39H2: A Comprehensive and Perspective View
Q27684424The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B
Q35644761The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene
Q42951897The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes.
Q24306590The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
Q38719928The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Q35948121The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2.
Q43023146The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation
Q24298299The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
Q34913126The Yeast Nucleosome Atlas (YNA) database: an integrative gene mining platform for studying chromatin structure and its regulation in yeast
Q47823343The cenH3 histone variant defines centromeres in Giardia intestinalis.
Q39028472The chromatin architectural proteins HMGD1 and H1 bind reciprocally and have opposite effects on chromatin structure and gene regulation
Q98289704The combination of G9a histone methyltransferase inhibitors with erythropoietin protects heart against damage from acute myocardial infarction
Q26824372The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals
Q58776048The critical role of histone lysine demethylase KDM2B in cancer
Q37897061The diverse functions of Dot1 and H3K79 methylation.
Q34414288The dynamic epitranscriptome: N6-methyladenosine and gene expression control
Q27652164The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure
Q37594007The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors
Q36739082The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes
Q64234131The epigenetic modulation of alcohol/ethanol and cannabis exposure/co-exposure during different stages
Q39893126The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling
Q37772356The epigenetics of breast cancer
Q38328034The expanding role of epigenetics.
Q52678626The expanding world of histone lysine demethylases.
Q24337617The first identification of lysine malonylation substrates and its regulatory enzyme
Q33286778The fission yeast Jmj2 reverses histone H3 Lysine 4 trimethylation
Q40181016The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2.
Q37480775The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
Q21144913The histone demethylase Jhdm1a regulates hepatic gluconeogenesis
Q47322315The histone demethylase KDM5A is required for the repression of astrocytogenesis and regulated by the translational machinery in neural progenitor cells.
Q48165427The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex.
Q37692579The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
Q42366629The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
Q28594155The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
Q24315146The histone methyltransferase, NSD2, enhances androgen receptor-mediated transcription
Q34799913The histone modifications governing TFF1 transcription mediated by estrogen receptor
Q42712672The impact of mitotic versus interphase chromatin architecture on the molecular flow of EGFP by pair correlation analysis
Q56707473The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair
Q24673723The landscape of histone modifications across 1% of the human genome in five human cell lines
Q48958620The level and distribution pattern of HP1β in the embryonic brain correspond to those of H3K9me1/me2 but not of H3K9me3.
Q26745514The many faces of histone H3K79 methylation
Q38063931The methylation landscape of tumour metastasis
Q40202913The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
Q36683908The necessity for in vivo functional analysis in human medical genetics
Q38234971The potential of epigenetic therapies in neurodegenerative diseases
Q35640798The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin
Q41473804The promise of epigenomic therapeutics in pancreatic cancer
Q92853822The protective role of carnosic acid in ischemic/reperfusion injury through regulation of autophagy under T2DM
Q38304373The retinoblastoma binding protein RBP2 is an H3K4 demethylase
Q38059664The role of DNA methylation and histone modifications in transcriptional regulation in humans.
Q28390036The role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not?
Q38015703The role of epigenetic regulation in stem cell and cancer biology
Q38215665The role of epigenetics in colorectal cancer
Q24609124The role of epigenetics in the pathology of diabetic complications
Q33813111The role of histone H4 biotinylation in the structure of nucleosomes
Q39197389The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinib-resistant chronic myeloid leukemia cells
Q41978659The site-specific installation of methyl-lysine analogs into recombinant histones
Q34528813The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure
Q28586006The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility
Q91665365The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment
Q34531694The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
Q50335555The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase
Q51741969Tissue- and expression level-specific chromatin looping at maize b1 epialleles.
Q46412662Total parenteral nutrition induces sustained hypomethylation of DNA in newborn guinea pigs
Q35557387Traceless semisynthesis of a set of histone 3 species bearing specific lysine methylation marks.
Q34318365Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4
Q33856955Transcription and post-transcriptional regulation of spermatogenesis
Q39260857Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: chromatin accessibility, histone methylation pattern, and the essential role of rest
Q38253795Transcription of inflammatory genes: long noncoding RNA and beyond
Q38592335Transcription of tandemly repetitive DNA: functional roles
Q35865320Transcription-coupled deposition of histone modifications during MHC class II gene activation
Q37398592Transcriptional and epigenetic functions of histone variant H2A.Z.
Q34425391Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat.
Q28508765Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism
Q37851288Transcriptional controls by nuclear fat-soluble vitamin receptors through chromatin reorganization
Q55260615Transcriptional regulation of metabolism in disease: From transcription factors to epigenetics.
Q37635781Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells
Q42624352Transcriptionally active heterochromatin in rye B chromosomes
Q36916418Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
Q39024215Transrepressive function of TLX requires the histone demethylase LSD1.
Q33289999Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica
Q42063435Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1.
Q34549869Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
Q27933649Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation
Q91708649Two-Level Protein Methylation Prediction using structure model-based features
Q34401922UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells
Q28484095UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
Q37456238Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy
Q38212817Unconventional post-translational modifications in immunological signaling
Q40275213Underrepresentation of active histone modification marks in evolutionarily young genes
Q61810256Unraveling the Regulation of Hepatic Gluconeogenesis
Q46323158Upon Infection the Cellular WD Repeat-containing Protein 5 (WDR5) Localizes to Cytoplasmic Inclusion Bodies and Enhances Measles Virus Replication
Q38811194Upregulated SMYD3 promotes bladder cancer progression by targeting BCLAF1 and activating autophagy
Q40069865Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors.
Q38691398Using zebrafish as a model to study the role of epigenetics in hearing loss
Q87873955Utx loss causes myeloid transformation
Q35580822WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission
Q82234832WD40 repeats arrange histone tails for spreading of silencing
Q30864695Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice.
Q34476349Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small molecules
Q41732083Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
Q39268171Writing, erasing and reading histone lysine methylations.
Q33853052Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.
Q27933253Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase
Q27935114Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation
Q33370931ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers
Q34637108ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
Q24337179Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP
Q55504750[Advances of histone methyltransferase SMYD3 in tumors].
Q52884814[Antiproliferative effect of silencing LSD1 gene on Jurkat cell line and its mechanism].
Q83879251[Methylation and other new concepts for the origin of hepatocellular carcinoma]
Q33604849c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis
Q33336609dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster
Q39783117gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci
Q24338336hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
Q37215471hSET1: a novel approach for colon cancer therapy

Search more.