Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification

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Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.00772-07
P3181OpenCitations bibliographic resource ID4440776
P932PMC publication ID1952162
P698PubMed publication ID17576814

P2093author name stringMarcie H Warner
Karen M Arndt
Kelli L Roinick
P2860cites workTranslating the Histone CodeQ22065840
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase IIQ24304135
The human PAF complex coordinates transcription with events downstream of RNA synthesisQ24307917
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomainsQ24541812
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modificationsQ24545952
The parafibromin tumor suppressor protein is part of a human Paf1 complexQ24557571
Histone sumoylation is associated with transcriptional repressionQ24656259
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
The yeast pafl-rNA polymerase II complex is required for full expression of a subset of cell cycle-regulated genesQ34100687
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoterQ34572737
Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongationQ34610561
Unsafe SETs: histone lysine methyltransferases and cancerQ34768876
ATP-dependent nucleosome remodeling complexes: enzymes tailored to deal with chromatinQ35719497
Movement of yeast transposable elements by gene conversionQ36312294
Control of transcription through intragenic patterns of nucleosome compositionQ36353496
Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiaeQ36570063
Biochemical and genetic characterization of a yeast TFIID mutant that alters transcription in vivo and DNA binding in vitroQ36815536
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.Q40313636
Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatinQ43430561
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.Q44094473
Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatinQ44997684
A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets.Q53652090
Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding ProteinQ58130306
6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiaeQ68167371
Dynamic methylation of alfalfa histone H3Q70589375
Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosageQ72802227
Expanded lysine acetylation specificity of Gcn5 in native complexesQ74456705
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylationQ27930884
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approachQ27931237
Separation of the Saccharomyces cerevisiae Paf1 complex from RNA polymerase II results in changes in its subnuclear localizationQ27933049
Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complexQ27933282
The Paf1 complex physically and functionally associates with transcription elongation factors in vivoQ27933848
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.Q27933975
Ribosomal protein L32 of Saccharomyces cerevisiae influences both the splicing of its own transcript and the processing of rRNA.Q27934408
A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast.Q27934434
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complexQ27934812
Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivoQ27934996
The Paf1 complex has functions independent of actively transcribing RNA polymerase II.Q27935078
Role for the silencing protein Dot1 in meiotic checkpoint controlQ27935732
The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiaeQ27935965
Histone H2B ubiquitylation is associated with elongating RNA polymerase IIQ27936299
The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.Q27937468
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylationQ27937996
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expressionQ27938795
Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genesQ27939654
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.Q27939794
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1pQ27940017
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeastQ28131604
Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeastQ28131609
Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288CQ28131625
Active genes are tri-methylated at K4 of histone H3Q29547668
Multiple sequence alignment with Clustal XQ29547758
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activityQ29555842
Double chromodomains cooperate to recognize the methylated histone H3 tailQ29614522
The diverse functions of histone lysine methylationQ29614523
Methylation of histone H3 Lys 4 in coding regions of active genesQ29614680
Transitions in RNA polymerase II elongation complexes at the 3' ends of genesQ29614767
The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiaeQ29614854
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeastQ29617217
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expressionQ29619380
Gene silencing: trans-histone regulatory pathway in chromatinQ30309681
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.Q33195734
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectregulation of histone H2B conserved C-terminal lysine ubiquitinationQ22245370
positive regulation of histone H2B conserved C-terminal lysine ubiquitinationQ22245371
negative regulation of histone H2B conserved C-terminal lysine ubiquitinationQ22245759
Rtf1p YGL244WQ27553073
cell biologyQ7141
P304page(s)6103-15
P577publication date2007-09-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleRtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification
P478volume27