The human PAF complex coordinates transcription with events downstream of RNA synthesis

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The human PAF complex coordinates transcription with events downstream of RNA synthesis is …
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scholarly articleQ13442814

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P356DOI10.1101/GAD.1292105
P8608Fatcat IDrelease_us3v3sbyfzc4nmbo6nj5ezor2q
P3181OpenCitations bibliographic resource ID2420394
P932PMC publication ID1176003
P698PubMed publication ID16024656
P5875ResearchGate publication ID7719505

P50authorHediye Erdjument-BromageQ25910537
Paul TempstQ25912123
Danny ReinbergQ28606470
Subhrangsu S MandalQ56419279
P2093author name stringAnh-Dung Pham
Bing Zhu
Surinder K Batra
Yong Zheng
P2860cites workSki7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeastQ24535685
The parafibromin tumor suppressor protein is part of a human Paf1 complexQ24557571
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylationQ27930884
The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivoQ27931202
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approachQ27931237
Identification of a regulated pathway for nuclear pre-mRNA turnover.Q27931532
Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complexQ27933282
The Paf1 complex physically and functionally associates with transcription elongation factors in vivoQ27933848
The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complexQ27934144
Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivoQ27934996
The Paf1 complex has functions independent of actively transcribing RNA polymerase II.Q27935078
An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradationQ27936597
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.Q27939794
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1pQ27940017
An extensive network of coupling among gene expression machinesQ29547273
Active genes are tri-methylated at K4 of histone H3Q29547668
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activityQ29555842
Elongation by RNA polymerase II: the short and long of itQ29614529
Histone H3 lysine 4 methylation patterns in higher eukaryotic genesQ29614678
A unified theory of gene expressionQ29615022
The yeast pafl-rNA polymerase II complex is required for full expression of a subset of cell cycle-regulated genesQ34100687
On the importance of being co-transcriptionalQ34150533
Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongationQ34610561
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylationQ35131664
The key to development: interpreting the histone code?Q36083253
Decoying the cap- mRNA degradation system by a double-stranded RNA virus and poly(A)- mRNA surveillance by a yeast antiviral systemQ36551077
Paf1p, an RNA polymerase II-associated factor in Saccharomyces cerevisiae, may have both positive and negative roles in transcriptionQ36557179
Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiaeQ36570063
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.Q36676944
Superkiller Mutations in Saccharomyces cerevisiae Suppress Exclusion of M2 Double-Stranded RNA by L-A-HN and Confer Cold Sensitivity in the Presence of M and L-A-HNQ36943809
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.Q37491118
PAF1-complex-mediated histone methylation of FLOWERING LOCUS C chromatin is required for the vernalization-responsive, winter-annual habit in Arabidopsis.Q37620957
The RNA processing exosome is linked to elongating RNA polymerase II in DrosophilaQ40682391
Precursor RNAs harboring nonsense codons accumulate near the site of transcriptionQ48347429
Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codonQ71386406
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stabilityQ71386453
A mechanism related to the yeast transcriptional regulator Paf1c is required for expression of the Arabidopsis FLC/MAF MADS box gene familyQ80837134
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectpositive regulation of histone H3-K79 methylationQ21109942
WD repeat domain 61Q21109944
CTR9 homolog, Paf1/RNA polymerase II complex componentQ21117093
Ski2 like RNA helicaseQ21117657
Tetratricopeptide repeat domain 37Q21121823
P304page(s)1668-1673
P577publication date2005-07-01
P1433published inGenes & DevelopmentQ1524533
P1476titleThe human PAF complex coordinates transcription with events downstream of RNA synthesis
P478volume19

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cites work (P2860)
Q27934649A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation
Q33351290A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation
Q41892815A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation
Q24312181A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity
Q30494523A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency
Q54402482A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans.
Q39443387A whole genome screen for HIV restriction factors
Q36082540Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
Q27342887Arabidopsis COMPASS-like complexes mediate histone H3 lysine-4 trimethylation to control floral transition and plant development
Q37628197Attacked from All Sides: RNA Decay in Antiviral Defense
Q28305130Biochemical studies of the mammalian exosome with intact cells
Q88609298Born to run: control of transcription elongation by RNA polymerase II
Q34561019Breaking barriers to transcription elongation
Q34674542CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation
Q28260762Cell and molecular biology of the exosome: how to make or break an RNA
Q37134608Cellular Stress and p53-Associated Apoptosis by Juniperus communis L. Berry Extract Treatment in the Human SH-SY5Y Neuroblastoma Cells
Q38460030Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex
Q21092435Chromatin Landscape Dictates HSF Binding to Target DNA Elements
Q38286121Chromatin modification by the RNA Polymerase II elongation complex
Q51701144Cln 3-requiring 9 is a negative regulator of Th17 pathway-driven inflammation in anti-glomerular basement membrane glomerulonephritis.
Q28482259Context-dependent dual role of SKI8 homologs in mRNA synthesis and turnover
Q53228284Cytoplasmic parafibromin/hCdc73 targets and destabilizes p53 mRNA to control p53-mediated apoptosis.
Q35029135Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.
Q24655388DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
Q41965480DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation
Q34993892Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome
Q36802258Degradation of mRNAs that lack a stop codon: a decade of nonstop progress
Q27933085Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.
Q34233474Drosophila Paf1 modulates chromatin structure at actively transcribed genes.
Q35033130Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling
Q27931099Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation
Q47859224Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation
Q33363084Genic and global functions for Paf1C in chromatin modification and gene expression in Arabidopsis
Q37257338Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo
Q24337471Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II
Q35889368Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription
Q28589560Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.
Q36864019Human RNA polymerase II-associated factor complex: dysregulation in cancer.
Q24295252Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer
Q35065497Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae
Q33742981Integrated analysis of recurrent properties of cancer genes to identify novel drivers
Q27935084Leo1 Subunit of the Yeast Paf1 Complex Binds RNA and Contributes to Complex Recruitment*
Q24680558Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes
Q37710711Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
Q24297025Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation
Q30445969Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance
Q37158405Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+]
Q33994268Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells
Q42663363OrthoNets: simultaneous visual analysis of orthologs and their interaction neighborhoods across different organisms
Q36772125Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma
Q35893857PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation
Q48112980PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters.
Q34245737PAFc, a key player in MLL-rearranged leukemogenesis
Q50133871PD2/PAF1 at the Crossroads of the Cancer Network
Q34101017PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
Q43110166PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin.
Q58726157Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
Q35986632Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation
Q93087705Paf1C regulates RNA polymerase II progression by modulating elongation rate
Q40150454Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen
Q28592704Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice
Q38955475Pathogenesis of Börjeson-Forssman-Lehmann syndrome: Insights from PHF6 function
Q48250929Phosphorylation of SPT5 by CDKD;2 Is Required for VIP5 Recruitment and Normal Flowering in Arabidopsis thaliana
Q40484287Potential role of Arabidopsis PHP as an accessory subunit of the PAF1 transcriptional cofactor
Q41077260Profile of histone lysine methylation across transcribed mammalian chromatin
Q26864165Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems
Q37034347Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation
Q33937012RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells
Q34960186RNA polymerase II transcription elongation control
Q28251052RNA-quality control by the exosome
Q41999449Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing
Q29614518Regulation of MLL1 H3K4 methyltransferase activity by its core components
Q37372391Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a
Q27929974Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification
Q35877863SKIV2L mutations cause syndromic diarrhea, or trichohepatoenteric syndrome.
Q36079423Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast
Q27680183Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin
Q27679957Structural insights into Paf1 complex assembly and histone binding
Q24306097Structure and DNA binding of the human Rtf1 Plus3 domain
Q59070952Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
Q96431678Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation
Q26825160Syndromic diarrhea/Tricho-hepato-enteric syndrome
Q42170268The Arabidopsis Paf1c complex component CDC73 participates in the modification of FLOWERING LOCUS C chromatin
Q38015891The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
Q35783618The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome
Q35079880The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast
Q24319075The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis
Q50457814The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans
Q27931337The Paf1 complex is required for efficient transcription elongation by RNA polymerase I
Q37671309The Paf1 complex: platform or player in RNA polymerase II transcription?
Q27933464The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.
Q35811839The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression
Q24293507The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export
Q24300720The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS
Q33505663The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progression
Q24298372The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions
Q55117047The ins and outs of HIV restriction.
Q36522035The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states
Q24312426The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene
Q24315774The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors
Q33608914The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression
Q38686217The upstreams and downstreams of H3K79 methylation by DOT1L.
Q39042789Transcription factors that influence RNA polymerases I and II: To what extent is mechanism of action conserved?
Q36855391Transcriptional Regulation of Heart Development in Zebrafish
Q24293440Transcriptional activators enhance polyadenylation of mRNA precursors
Q40339336Transcriptional activators enhance polyadenylation of mRNA precursors.
Q35458713Transcriptional activity regulates alternative cleavage and polyadenylation
Q52661406Tricho-Hepato-Enteric Syndrome mutation update: Mutations spectrum of TTC37 and SKIV2L, clinical analysis and future prospects.
Q24293427WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription
Q92099533Why are so many MLL lysine methyltransferases required for normal mammalian development?
Q24629119c-Myc regulates transcriptional pause release
Q28590862hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions
Q37716449hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells.

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