The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

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The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene is …
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scholarly articleQ13442814

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P819ADS bibcode2008PNAS..10517420L
P356DOI10.1073/PNAS.0710725105
P8608Fatcat IDrelease_ktw3yap2ynd67eiuryycbsyaqq
P3181OpenCitations bibliographic resource ID3401312
P932PMC publication ID2582266
P698PubMed publication ID18987311
P5875ResearchGate publication ID23454531

P2093author name stringLing Lin
Jian-Hua Zhang
William F Simonds
Leelamma M Panicker
P2860cites workParafibromin inhibits cancer cell growth and causes G1 phase arrestQ24304063
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase IIQ24304135
The human PAF complex coordinates transcription with events downstream of RNA synthesisQ24307917
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/ArmadilloQ24319343
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase IIQ24337471
The parafibromin tumor suppressor protein is part of a human Paf1 complexQ24557571
Germline and de novo mutations in the HRPT2 tumour suppressor gene in familial isolated hyperparathyroidism (FIHP)Q24675703
HRPT2 mutations are associated with malignancy in sporadic parathyroid tumoursQ24676397
Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expressionQ33209570
p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrestQ33925109
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndromeQ34159232
Somatic and Germ-Line Mutations of theHRPT2Gene in Sporadic Parathyroid CarcinomaQ34273263
Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome.Q34289020
Hyperparathyroidism-jaw tumour syndromeQ35130899
Perturbations of the AKT signaling pathway in human cancerQ36313181
Intrinsic sites of transcription termination and pausing in the c-myc geneQ36847325
Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic functionQ40168423
Ras enhances Myc protein stability.Q40967066
c-myc protein expression in untransformed fibroblastsQ41684755
Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: a clinically and genetically distinct syndromeQ44258546
Accumulation of nonphosphorylated beta-catenin and c-myc in primary and uremic secondary hyperparathyroid tumorsQ45345276
Ras mediates cell survival by regulating tuberinQ46961792
The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal regionQ49162171
Diagnosis of parathyroid tumors in familial isolated hyperparathyroidism with HRPT2 mutation: implications for cancer surveillance.Q54600169
Parafibromin mutations in hereditary hyperparathyroidism syndromes and parathyroid tumours.Q54617217
Influence of calcium and 1,25-dihydroxycholecalciferol on proliferation and proto-oncogene expression in primary cultures of bovine parathyroid cells.Q64889594
Genetic analyses in patients with familial isolated hyperparathyroidism and hyperparathyroidism-jaw tumour syndromeQ79832233
Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutationQ80331561
Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumorsQ80974820
P433issue45
P407language of work or nameEnglishQ1860
P921main subjectMYC proto-oncogene, bHLH transcription factorQ420267
Cell division cycle 73Q21113887
LEO1 homolog, Paf1/RNA polymerase II complex componentQ21117100
peroxisomal biogenesis factor 2Q21122491
P304page(s)17420-5
P577publication date2008-11-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene
P478volume105

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cites work (P2860)
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Q43110166PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin.
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