hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells.

scientific article published on 20 January 2017

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.14775
P932PMC publication ID5362445
P698PubMed publication ID28122356

P50authorParthasarathy SeshacharyuluQ51138077
Imayavaramban LakshmananQ59681803
Sidharth MahapatraQ59756613
P2093author name stringSurinder K Batra
Moorthy P Ponnusamy
Seema Chugh
Arokia P Vaz
Saswati Karmakar
Yuri M Sheinin
P2860cites workFormation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4Q22008002
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancerQ24295252
The human PAF complex coordinates transcription with events downstream of RNA synthesisQ24307917
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identityQ24312181
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase IIQ24337471
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatmentQ24656967
Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cellsQ24657573
19q13 amplification is associated with high grade and stage in pancreatic cancerQ40045624
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.Q40313636
Cancer of the ovary, fallopian tube, and peritoneumQ41266914
DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancerQ41906889
CD44 is of Functional Importance for Colorectal Cancer Stem CellsQ58022858
Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cellsQ64376527
Oct-3/4 is a dose-dependent oncogenic fate determinantQ79358420
CD24, a novel cancer biomarker, predicting disease-free survival of non-small cell lung carcinomas: a retrospective study of prognostic factor analysis from the viewpoint of forthcoming (seventh) new TNM classificationQ83955619
Development and applications of CRISPR-Cas9 for genome engineeringQ28241526
Asymmetric and symmetric stem-cell divisions in development and cancerQ28249478
Cancer stem cells in solid tumours: accumulating evidence and unresolved questionsQ28293535
Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cellsQ28473082
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cellsQ28590205
CRISPR-Cas systems for editing, regulating and targeting genomesQ29615781
Tumour stem cells and drug resistanceQ29617742
Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan OligosaccharidesQ30478184
The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progressionQ33505663
The role of cancer stem cells and the side population in epithelial ovarian cancerQ33516247
Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistantQ33547790
RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cellsQ33937012
Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cellsQ33994268
CRISPR/Cas9-mediated gene knock-down in post-mitotic neuronsQ34070995
PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasiaQ34101017
Cancer stem cells: an old idea--a paradigm shiftQ34495973
Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2.Q34569371
Part I: chemotherapy for epithelial ovarian cancer-treatment at first diagnosisQ34826546
Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cellsQ35190005
Ovarian cancer stem cell markers: prognostic and therapeutic implicationsQ35606242
A concise review on the current understanding of pancreatic cancer stem cellsQ35801362
Ovarian cancer metastasis: integrating insights from disparate model organismsQ36111930
ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cellsQ36165630
PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase IIQ36371761
Small putative NANOG, SOX2, and SSEA-4-positive stem cells resembling very small embryonic-like stem cells in sections of ovarian tissue in patients with ovarian cancerQ36651828
Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinomaQ36772125
Human RNA polymerase II-associated factor complex: dysregulation in cancer.Q36864019
Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway.Q36959063
Ovarian cancer: emerging concept on cancer stem cellsQ36975266
Cancer stem cells and therapeutic targets: an emerging field for cancer treatmentQ37200395
EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/β-catenin signalingQ37520284
Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells.Q38060596
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.Q38812273
Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cellsQ38939676
Interleukin-17 produced by tumor microenvironment promotes self-renewal of CD133+ cancer stem-like cells in ovarian cancerQ39041030
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
neoplastic stem cellsQ1638475
P304page(s)14806-14820
P577publication date2017-02-01
P1433published inOncotargetQ1573155
P1476titlehPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells
P478volume8

Reverse relations

cites work (P2860)
Q92871476Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
Q90452178Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?
Q54977179Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.
Q47593475Diagnostic and Prognostic Biomarkers in ovarian cancer and the potential roles of cancer stem cells - An updated review
Q47859224Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation
Q58790596Novel endocrine therapeutic strategy in endometrial carcinoma targeting estrogen-related receptor α by XCT790 and siRNA
Q59327036Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells
Q50133871PD2/PAF1 at the Crossroads of the Cancer Network
Q96169030Proteins and Molecular Pathways Relevant for the Malignant Properties of Tumor-Initiating Pancreatic Cancer Cells
Q104111327Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis
Q64097285The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models
Q93007759Unraveling the journey of cancer stem cells from origin to metastasis