Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

scientific article

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.1144003
P3181OpenCitations bibliographic resource ID1154415
P932PMC publication ID280615
P698PubMed publication ID14563679
P5875ResearchGate publication ID5428531

P50authorAli ShilatifardQ15989733
Shelley L. BergerQ51827958
Lorraine PillusQ87698814
P2093author name stringAnastasia Wyce
Cheng-Fu Kao
Karl W Henry
Laura J Duggan
Mary Ann Osley
N C Tolga Emre
Wan-Sheng Lo
P2860cites workFunctional organization of the yeast proteome by systematic analysis of protein complexesQ24292209
The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairsQ24554357
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehydeQ27640257
The language of covalent histone modificationsQ27860931
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryQ27861116
Histone H3 specific acetyltransferases are essential for cell cycle progressionQ27929940
The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complexQ27930726
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.Q27930736
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylationQ27930884
The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiaeQ27931014
Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometryQ27931371
ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB.Q27931384
Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylasesQ27931861
Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiaeQ27932938
The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongationQ27933486
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoterQ27933859
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.Q27934010
The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.Q27934606
Analysis of Spt7 function in the Saccharomyces cerevisiae SAGA coactivator complex.Q27934769
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complexQ27934812
SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcriptionQ27936016
A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulationQ27936635
The ATM-related cofactor Tra1 is a component of the purified SAGA complexQ27937594
Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promotersQ27938704
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.Q27939794
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1pQ27940017
The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.Q27940298
The tandem affinity purification (TAP) method: a general procedure of protein complex purificationQ28131621
Dissecting the regulatory circuitry of a eukaryotic genomeQ28131632
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiaeQ28343956
SAGA is an essential in vivo target of the yeast acidic activator Gal4pQ28345347
Active genes are tri-methylated at K4 of histone H3Q29547668
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activityQ29555842
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase IIQ29614679
Methylation of histone H3 Lys 4 in coding regions of active genesQ29614680
Dot1p modulates silencing in yeast by methylation of the nucleosome coreQ29614855
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeastQ29617217
Rad6-dependent ubiquitination of histone H2B in yeastQ29617525
Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundariesQ29622865
Gene silencing: trans-histone regulatory pathway in chromatinQ30309681
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.Q33911284
Emerging roles of ubiquitin in transcription regulationQ34129014
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Q34133875
Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongationQ34154556
The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.Q34168365
HDAC's at work: everyone doing their partQ34671229
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegationQ34762156
Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiaeQ35114839
The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivoQ35209265
Reversible histone modification and the chromosome cell cycleQ35225904
Paf1p, an RNA polymerase II-associated factor in Saccharomyces cerevisiae, may have both positive and negative roles in transcriptionQ36557179
The E2 ubiquitin conjugase Rad6 is required for the ArgR/Mcm1 repression of ARG1 transcriptionQ39406784
Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7.Q39458102
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeastQ39895202
Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repressionQ40023668
Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatinQ41307223
RAD6 gene product of Saccharomyces cerevisiae requires a putative ubiquitin protein ligase (E3) for the ubiquitination of certain proteins.Q42118407
Regulation of transcriptional activation domain function by ubiquitinQ43682027
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locusQ43703042
Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanismQ43871051
Level of ubiquitinated histone H2B in chromatin is coupled to ongoing transcriptionQ44511165
The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activityQ44992776
Requirement of Hos2 histone deacetylase for gene activity in yeastQ46070318
Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ADA3pQ48062271
Histones are first hyperacetylated and then lose contact with the activated PHO5 promoter.Q51599592
Nucleosomes unfold completely at a transcriptionally active promoter.Q51599596
TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes.Q52532015
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectUbiquitin-specific protease UBP8 YMR223WQ27547304
ubiquitinationQ33059483
P304page(s)2648-63
P577publication date2003-11-01
P1433published inGenes & DevelopmentQ1524533
P1476titleTranscriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.
P478volume17

Reverse relations

cites work (P2860)
Q28081868(Ubi)quitin' the h2bit: recent insights into the roles of H2B ubiquitylation in DNA replication and transcription
Q42936226A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation
Q27670664A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity
Q24307408A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing
Q38551630A brief histone in time: understanding the combinatorial functions of histone PTMs in the nucleosome context
Q34313810A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit
Q36723292A genetic and molecular toolbox for analyzing histone ubiquitylation and sumoylation in yeast.
Q33691600A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity
Q24314096A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
Q24337802A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
Q80837134A mechanism related to the yeast transcriptional regulator Paf1c is required for expression of the Arabidopsis FLC/MAF MADS box gene family
Q37829707A modified epigenetics toolbox to study histone modifications on the nucleosome core.
Q37947760A new chapter in the transcription SAGA.
Q30448402A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation
Q33565860A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression
Q27939024A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.
Q27934274A role for H2B ubiquitylation in DNA replication
Q62019752A role for Mog1 in H2Bub1 and H3K4me3 regulation affecting RNAPII transcription and mRNA export
Q36451302A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling.
Q37994551ATAC-king the complexity of SAGA during evolution
Q42772802ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Q34165906Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer
Q50893480Activation of gene expression by histone deubiquitinase OTLD1.
Q58375318Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins
Q36065229Aggregation of Polyglutamine-expanded Ataxin 7 Protein Specifically Sequesters Ubiquitin-specific Protease 22 and Deteriorates Its Deubiquitinating Function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex
Q37246670Alterations of histone modifications by cobalt compounds
Q37352446Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation
Q64063488Architecture of SAGA complex
Q36289979Ascending the nucleosome face: recognition and function of structured domains in the histone H2A-H2B dimer
Q83230336Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization
Q46722207Atg19p ubiquitination and the cytoplasm to vacuole trafficking pathway in yeast
Q57246269BAP1 links metabolic regulation of ferroptosis to tumour suppression
Q38122765Balancing chromatin remodeling and histone modifications in transcription
Q36752292Biology of polycomb and trithorax group proteins
Q89531833Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
Q44778228C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary function.
Q96136649CRISPR screen in regulatory T cells reveals modulators of Foxp3
Q24318345Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6
Q44683549Carbohydrates induce mono-ubiquitination of H2B in yeast
Q24654957Catalysis and substrate selection by histone/protein lysine acetyltransferases
Q33984490Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription
Q48331605Centromeric histone H2B monoubiquitination promotes noncoding transcription and chromatin integrity
Q36416226Characterization of new Spt3 and TATA-binding protein mutants of Saccharomyces cerevisiae: Spt3 TBP allele-specific interactions and bypass of Spt8.
Q27937996Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation
Q37093722Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.
Q40343286Chemical answers to epigenetic crosstalk.
Q46177112Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans
Q38987852Choose Your Own Adventure: The Role of Histone Modifications in Yeast Cell Fate
Q22065678Chromatin dynamics at DNA replication, transcription and repair
Q37961878Chromatin response to DNA double-strand break damage
Q33285644Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination
Q82282561Chromatin-modifying enzymes as therapeutic targets--Part 2
Q27937089Cluster analysis of mass spectrometry data reveals a novel component of SAGA
Q27932566Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes
Q26777171Composition of the SAGA complex in plants and its role in controlling gene expression in response to abiotic stresses
Q35450959Conformational flexibility and subunit arrangement of the modular yeast Spt-Ada-Gcn5 acetyltransferase complex
Q59070695Control of DNA methylation and heterochromatic silencing by histone H2B deubiquitination
Q27932002Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.
Q37275279Controlling histone methylation via trans-histone pathways
Q41005310Cooperation between SAGA and SWI/SNF complexes is required for efficient transcriptional responses regulated by the yeast MAPK Slt2.
Q39249006Coordinated Actions of MicroRNAs with other Epigenetic Factors Regulate Skeletal Muscle Development and Adaptation
Q37777788Core histone H2A ubiquitylation and transcriptional regulation
Q38973004Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate
Q36994153Covalent modifications of histones during development and disease pathogenesis
Q36994157Cross-regulation of histone modifications
Q36226144Cross-talking histones: implications for the regulation of gene expression and DNA repair
Q41559771Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution
Q35642090Ctk complex-mediated regulation of histone methylation by COMPASS.
Q58759904DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis
Q38336126DUBs, the regulation of cell identity and disease
Q37069551Deciphering histone 2A deubiquitination
Q38695071Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint
Q35056454Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors.
Q37358677Decreased histone H2B monoubiquitination in malignant gastric carcinoma
Q36678362Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model
Q33195734Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.
Q43064198Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack
Q28585918Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
Q90575977Dissenting degradation: Deubiquitinases in cell cycle and cancer
Q34478777Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID
Q35203861Divergence and selectivity of expression-coupled histone modifications in budding yeasts
Q28469221Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans
Q46495750Down-regulation of Pkc1-mediated signaling by the deubiquitinating enzyme Ubp3.
Q96950736Dynamic modules of the coactivator SAGA in eukaryotic transcription
Q47104531E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae.
Q28594870EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape
Q27936758Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.
Q35910114Emerging Views on the CTD Code
Q39554519Enzymatic assays for assessing histone deubiquitylation activity.
Q58597542Epigenetic mechanisms and implications in tendon inflammation (Review)
Q38018086Epigenetic mechanisms in gastric cancer
Q26740004Epigenetic memory: A macrophage perspective
Q38002825Epigenetic regulation of kallikrein-related peptidases: there is a whole new world out there
Q36164758Epigenome programming by Polycomb and Trithorax proteins.
Q33347428Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditions
Q61809019FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics
Q35860533Feedback Control of Snf1 Protein and Its Phosphorylation Is Necessary for Adaptation to Environmental Stress
Q26781153Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work
Q42551223Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo
Q35577991Flickin' the ubiquitin switch: the role of H2B ubiquitylation in development
Q26781247Functional Role of G9a Histone Methyltransferase in Cancer
Q36742165Functional analysis of Bre1p, an E3 ligase for histone H2B ubiquitylation, in regulation of RNA polymerase II association with active genes and transcription in vivo
Q42685039Functional analysis of H2B-Lys-123 ubiquitination in regulation of H3-Lys-4 methylation and recruitment of RNA polymerase II at the coding sequences of several active genes in vivo
Q37468898Functional connection between histone acetyltransferase Gcn5p and methyltransferase Hmt1p
Q26744570Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress
Q33493740Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.
Q42065419Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe.
Q35917883Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p
Q36994161Gene regulation through nuclear organization.
Q36076885Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.
Q35124229Genetic interactions between POB3 and the acetylation of newly synthesized histones
Q39196606Genome-wide function of H2B ubiquitylation in promoter and genic regions
Q35681247Getting into position: the catalytic mechanisms of protein ubiquitylation
Q38324759Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae
Q35294605H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly
Q36021719H2B monoubiquitylation is a 5'-enriched active transcription mark and correlates with exon-intron structure in human cells
Q27939759H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.
Q34107829H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast.
Q92686725Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators
Q24309403Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Q24642681Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
Q33963926Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination.
Q53440183Histone H2B Monoubiquitination Mediated by HISTONE MONOUBIQUITINATION1 and HISTONE MONOUBIQUITINATION2 Is Involved in Anther Development by Regulating Tapetum Degradation-Related Genes in Rice.
Q83012234Histone H2B deubiquitination is required for transcriptional activation of FLOWERING LOCUS C and for proper control of flowering in Arabidopsis
Q34350965Histone H2B monoubiquitination facilitates the rapid modulation of gene expression during Arabidopsis photomorphogenesis
Q33346128Histone H2B monoubiquitination in the chromatin of FLOWERING LOCUS C regulates flowering time in Arabidopsis
Q26825542Histone H2B monoubiquitination: roles to play in human malignancy
Q35592200Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation
Q41984790Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe
Q37361776Histone H2B ubiquitination: the cancer connection
Q36238608Histone H2B ubiquitylation and deubiquitylation in genomic regulation.
Q27936299Histone H2B ubiquitylation is associated with elongating RNA polymerase II
Q37454264Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena
Q36896407Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus.
Q37309152Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.
Q42229711Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.
Q39891491Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression
Q33930752Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms
Q30433574Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders
Q29620006Histone acetyltransferase complexes: one size doesn't fit all
Q36001847Histone deacetylase inhibitors: clinical implications for hematological malignancies
Q37705706Histone modifications as regulators of life and death in Saccharomyces cerevisiae
Q37087015Histone modifications: Now summoning sumoylation
Q33761580Histone modifying enzymes: structures, mechanisms, and specificities
Q36078818Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.
Q24545952Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
Q35971184Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer
Q28081194Histone ubiquitylation and its roles in transcription and DNA damage response
Q43205547How epigenetics integrates nuclear functions. Workshop on epigenetics and chromatin: transcriptional regulation and beyond
Q37514183How eukaryotic genes are transcribed
Q45018971Human TREX2 components PCID2 and centrin 2, but not ENY2, have distinct functions in protein export and co-localize to the centrosome
Q24299488Human USP3 is a chromatin modifier required for S phase progression and genome stability
Q89503067Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action
Q42096517Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex
Q36119924Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation
Q37737546Inducible gene expression: diverse regulatory mechanisms
Q34671609Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activation.
Q37553936Insights into SAGA function during gene expression
Q36323434Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination
Q37797693Interplay Between Different Epigenetic Modifications and Mechanisms
Q35476430Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.
Q35091097Involvement of KDM1C histone demethylase-OTLD1 otubain-like histone deubiquitinase complexes in plant gene repression
Q89126426Light and temperature shape nuclear architecture and gene expression
Q37418113Light behind the curtain: photoregulation of nuclear architecture and chromatin dynamics in plants
Q41888822Light-induced nuclear export reveals rapid dynamics of epigenetic modifications
Q91890923LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis
Q33837026Mapping global histone methylation patterns in the coding regions of human genes
Q36580193Mapping histone modifications by nucleosome immunoprecipitation
Q24307834Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylation
Q43122609Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation
Q40001798Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells
Q24297025Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation
Q30443104Multi-tasking on chromatin with the SAGA coactivator complexes
Q42045741Multiple faces of the SAGA complex
Q27931794Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle
Q27930623Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.
Q27933670Mutational uncoupling of the role of Sus1 in nuclear pore complex targeting of an mRNA export complex and histone H2B deubiquitination
Q40251253Ni(II) affects ubiquitination of core histones H2B and H2A.
Q90185691Nipped-A regulates the Drosophila circadian clock via histone deubiquitination
Q33963762Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A.
Q42114752Nucleosomal H2B ubiquitylation with purified factors
Q46268719On your MARKS, get SET, METHYLATE!
Q42598151Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter
Q30445180Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis.
Q89621389Plant Chromatin Catches the Sun
Q36854975Polyubiquitylation of histone H2B.
Q42609408Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation
Q26852536Post-translational modifications of histones that influence nucleosome dynamics
Q33370815Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants
Q39673659Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae.
Q37249177Protein modifications in transcription elongation
Q36554464Protein monoubiquitylation: targets and diverse functions
Q36199691Proteomic analysis revealed nitrogen-mediated metabolic, developmental, and hormonal regulation of maize (Zea mays L.) ear growth
Q30375585Quantitative proteomic analysis of histone modifications
Q40406028Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo
Q36029959RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
Q34995984RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression
Q37914341RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.
Q26799882RNF20-SNF2H Pathway of Chromatin Relaxation in DNA Double-Strand Break Repair
Q27930655Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B.
Q27932934Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis
Q41999449Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing
Q39030776Recognition of ubiquitinated nucleosomes.
Q28270922Recombination-activating gene proteins: more regulation, please
Q24645701Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes
Q39705425Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae.
Q24793292Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
Q24296401Regulation of cell cycle progression and gene expression by H2A deubiquitination
Q34606198Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.
Q42070422Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane
Q38855269Regulation of pluripotency and differentiation by deubiquitinating enzymes
Q33431467Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae
Q35105237Rescue of DNA damage-stalled RNA Pol II: histone H2B in action
Q48014985Retracted: Histone H2B ubquitination regulates retinoic acid signaling through the cooperation of ASXL1 and BAP1.
Q26773800Role of Deubiquitinating Enzymes in DNA Repair
Q41493041Role of Doa1 in the Saccharomyces cerevisiae DNA damage response
Q24305090Role of histone H2A ubiquitination in Polycomb silencing
Q34115523Rrd1p, an RNA polymerase II-specific prolyl isomerase and activator of phosphoprotein phosphatase, promotes transcription independently of rapamycin response
Q27929974Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification
Q36574522SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4.
Q92531896SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis
Q47790116SAGA Is a General Cofactor for RNA Polymerase II Transcription.
Q41620842SAGA complex components and acetate repression in Aspergillus nidulans
Q42552805SAGA function in tissue-specific gene expression
Q27934681SAGA-associated Sgf73p facilitates formation of the preinitiation complex assembly at the promoters either in a HAT-dependent or independent manner in vivo
Q41953553SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system
Q53556000SIN-fully silent: HDAC complexes in fission yeast.
Q36421035STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation
Q42289702Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene.
Q21129202Seed dormancy and germination-emerging mechanisms and new hypotheses
Q61207709Separation of a functional deubiquitylating module from the SAGA complex by the proteasome regulatory particle
Q27930044Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo
Q36073403Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.
Q47721313Sharing the SAGA.
Q28511362Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis
Q27026725Single molecule and single cell epigenomics.
Q36079423Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast
Q33628559Snf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p
Q35559126Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123.
Q27661081Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module
Q27660560Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module
Q42196568Structural and biochemical analyses of monoubiquitinated human histones H2B and H4.
Q36892380Structural basis for histone H2B deubiquitination by the SAGA DUB module.
Q27646584Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.
Q45889376Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA.
Q92860926Structure of the transcription coactivator SAGA
Q36942429Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2.
Q38051409Sus1/ENY2: a multitasking protein in eukaryotic gene expression
Q33940735Sus1p facilitates pre-initiation complex formation at the SAGA-regulated genes independently of histone H2B de-ubiquitylation
Q24545962TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele
Q53201323Targeting the epigenome for treatment of cancer.
Q41841500Temperature-sensitive post-translational regulation of plant omega-3 fatty-acid desaturases is mediated by the endoplasmic reticulum-associated degradation pathway
Q37592212Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex
Q28742012The C-terminus of histone H2B is involved in chromatin compaction specifically at telomeres, independently of its monoubiquitylation at lysine 123
Q26765873The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming
Q35104140The Ino80 complex prevents invasion of euchromatin into silent chromatin
Q27935220The N-terminus and Tudor domains of Sgf29 are important for its heterochromatin boundary formation function
Q35737433The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae
Q27935853The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II
Q42782209The Paf1 complex represses ARG1 transcription in Saccharomyces cerevisiae by promoting histone modifications
Q38627903The Paf1 complex represses SER3 transcription in Saccharomyces cerevisiae by facilitating intergenic transcription-dependent nucleosome occupancy of the SER3 promoter
Q52329552The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes.
Q35811839The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression
Q36995417The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Q36955793The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.
Q34235677The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.
Q30438554The SAGA continues: expanding the cellular role of a transcriptional co-activator complex
Q41521346The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast
Q34824438The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.
Q51415405The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally.
Q39761741The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing
Q34769706The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex in Aspergillus nidulans
Q35910444The Transition of Poised RNA Polymerase II to an Actively Elongating State Is a "Complex" Affair
Q24337279The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination
Q27932371The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae
Q48081222The absence of histone H2B monoubiquitination in the Arabidopsis hub1 (rdo4) mutant reveals a role for chromatin remodeling in seed dormancy
Q47069099The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans
Q38352748The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNA
Q34566036The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes
Q28131748The complex language of chromatin regulation during transcription
Q27932453The deubiquitylation activity of Ubp8 is dependent upon Sgf11 and its association with the SAGA complex
Q29614523The diverse functions of histone lysine methylation
Q35666251The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
Q38008101The enigmatic role of H2Bub1 in cancer
Q39140357The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2).
Q37186709The epigenetics of adult (somatic) stem cells
Q24318500The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression
Q24298372The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions
Q49723158The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin.
Q58616112The kinetochore module Okp1/Ame1 is a reader for N-terminal modifications on the centromeric histone Cse4
Q27940177The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.
Q37862125The multifaceted roles of USP7: new therapeutic opportunities
Q36579378The multiple faces of Set1.
Q92937229The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo
Q28240753The nucleosome: from genomic organization to genomic regulation
Q24307439The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression
Q35147589The role of Candida albicans SPT20 in filamentation, biofilm formation and pathogenesis
Q34564968The role of deubiquitinating enzymes in chromatin regulation.
Q80188867The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain
Q24338865The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties
Q34199540The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements
Q50335555The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase
Q33600336The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids.
Q36268060The ubiquitin-proteasome system of Saccharomyces cerevisiae
Q27934454The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.
Q49601869The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase
Q27937658The yeast SR-like protein Npl3 links chromatin modification to mRNA processing
Q27937396Tight cooperation between Mot1p and NC2β in regulating genome-wide transcription, repression of transcription following heat shock induction and genetic interaction with SAGA
Q24314891Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
Q57970965Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair
Q38043829Transcription-associated histone modifications and cryptic transcription
Q42133855Transcriptional elongation and mRNA export are coregulated processes.
Q36040816Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development
Q36830110Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System
Q92490294Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA
Q80049453Two tales of chromatin remodeling converge on HUB1
Q38953607Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation
Q42074560UBIQUITIN-SPECIFIC PROTEASE 26 is required for seed development and the repression of PHERES1 in Arabidopsis.
Q88909318USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism
Q34374287USP22 is useful as a novel molecular marker for predicting disease progression and patient prognosis of oral squamous cell carcinoma
Q24311562USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A
Q38729273USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.
Q24297433USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing
Q34144605UV damage-induced RNA polymerase II stalling stimulates H2B deubiquitylation
Q47359149Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer
Q38702950Ubiquitin crosstalk connecting cellular processes
Q26750743Ubiquitin-specific peptidase 22 functions and its involvement in disease
Q38924763Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination
Q37679191Ubiquitination regulates the morphogenesis and function of sperm organelles
Q33884138Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin
Q35139409Ubp8 and SAGA regulate Snf1 AMP kinase activity.
Q42222766Ubp8p, a histone deubiquitinase whose association with SAGA is mediated by Sgf11p, differentially regulates lysine 4 methylation of histone H3 in vivo
Q27931833Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity
Q43088502Using glycinylation, a chemical derivatization technique, for the quantitation of ubiquitinated proteins
Q24293427WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription
Q49911687Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe.
Q26742134Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair
Q27936733Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export
Q27935396Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes
Q45954525dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.
Q35442854dRYBP counteracts chromatin-dependent activation and repression of transcription
Q47134084let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery