Snf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p

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Snf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p is …
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scholarly articleQ13442814

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P356DOI10.1534/GENETICS.109.110957
P932PMC publication ID2815934
P698PubMed publication ID19841091
P5875ResearchGate publication ID38022142

P2093author name stringYang Liu
Min-Hao Kuo
Xinjing Xu
P2860cites workHuman TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 familyQ24321892
Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme AQ27618906
Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme AQ27618997
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivatorQ27619265
Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptideQ27619606
Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substratesQ27642747
A generic protein purification method for protein complex characterization and proteome explorationQ27861087
Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivoQ27930390
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.Q27930736
ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB.Q27931384
Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditionsQ27931460
Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunitQ27931918
An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4pQ27932320
The deubiquitylation activity of Ubp8 is dependent upon Sgf11 and its association with the SAGA complexQ27932453
Histone H2A.Z regulats transcription and is partially redundant with nucleosome remodeling complexesQ27933818
GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein.Q27933920
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.Q27933975
Positive and negative functions of the SAGA complex mediated through interaction of Spt8 with TBP and the N-terminal domain of TFIIA.Q27933987
Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes.Q27934188
The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.Q27934606
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complexQ27934812
SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitmentQ27934876
SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcriptionQ27936016
A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulationQ27936635
The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcriptionQ27937037
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylationQ27937996
Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promotersQ27938704
Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylationQ27939467
H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.Q27939759
The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.Q27940298
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiaeQ28131599
Getting started with yeastQ28131602
Improved method for high efficiency transformation of intact yeast cellsQ28131608
Dissecting the regulatory circuitry of a eukaryotic genomeQ28131632
Roles of histone acetyltransferases and deacetylases in gene regulationQ28286019
Histone acetyltransferasesQ29547823
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?Q29618125
GCN5-related N-acetyltransferases: a structural overviewQ29619219
In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environmentQ30304486
Identification of histone H3 lysine 36 acetylation as a highly conserved histone modificationQ30437262
Cell cycle-regulated histone acetylation required for expression of the yeast HO geneQ30448772
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.Q33195734
Structure and mechanism of action of the histone acetyltransferase Gcn5 and similarity to other N-acetyltransferasesQ33701946
Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo.Q33886079
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.Q33911284
Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanismsQ33930752
Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexesQ33970848
The SANT domain: a unique histone-tail-binding module?Q34308307
Regulation of TATA-binding protein binding by the SAGA complex and the Nhp6 high-mobility group protein.Q34740357
Analysis of the yeast SPT3 gene and identification of its product, a positive regulator of Ty transcriptionQ35050869
A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzymeQ35171792
Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivoQ35192911
Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivoQ35193069
The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivoQ35209265
H2B ubiquitylation and de-ubiquitylation in gene activation.Q35788645
GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeastQ36383484
Characterization of new Spt3 and TATA-binding protein mutants of Saccharomyces cerevisiae: Spt3 TBP allele-specific interactions and bypass of Spt8.Q36416226
SNF1/AMPK pathways in yeastQ36992466
The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.Q36995417
Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complexQ37493427
Redundant roles for the TFIID and SAGA complexes in global transcriptionQ38311191
Activation of the Saccharomyces cerevisiae Heat Shock Transcription Factor Under Glucose Starvation Conditions by Snf1 Protein KinaseQ38348172
Mutations in chromatin components suppress a defect of Gcn5 protein in Saccharomyces cerevisiaeQ39574370
Multiple Mechanistically Distinct Functions of SAGA at the PHO5 PromoterQ39787518
Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expressionQ39891491
Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repressionQ40023668
Spt3 and Mot1 cooperate in nucleosome remodeling independently of TBP recruitmentQ40832620
The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB.Q41178324
Molecular requirements for gene expression mediated by targeted histone acetyltransferasesQ41296285
Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferaseQ41913369
Global histone acetylation and deacetylation in yeastQ42496713
Molecular architecture of the S. cerevisiae SAGA complex.Q42631699
Site-specific cross-linking of TBP in vivo and in vitro reveals a direct functional interaction with the SAGA subunit Spt3.Q43247301
Mutational analysis of conserved residues in the GCN5 family of histone acetyltransferasesQ43633793
Snf1--a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription.Q43703058
The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complexQ43845830
Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeastQ47858497
A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiaeQ48017973
Histone acetyltransferase complexes stabilize swi/snf binding to promoter nucleosomes.Q52542735
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions.Q53577981
Gcn5p, a Transcription-related Histone Acetyltransferase, Acetylates Nucleosomes and Folded Nucleosomal Arrays in the Absence of Other Protein SubunitsQ58514612
Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysinesQ59051030
The Gcn5 bromodomain co-ordinates nucleosome remodellingQ59096973
SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiaeQ68203604
Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcriptionQ73406568
Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivatorQ77895379
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1Q77993773
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages15
P304page(s)91-105
P577publication date2009-10-19
P1433published inGeneticsQ3100575
P1476titleSnf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p
P478volume184

Reverse relations

cites work (P2860)
Q26800074Glucose repression in Saccharomyces cerevisiae
Q37973332Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae.
Q42741230Identification of Tension Sensing Motif of Histone H3 in Saccharomyces cerevisiae and Its Regulation by Histone Modifying Enzymes
Q54509131Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast.
Q35682118Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae
Q36381895Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5.
Q34374051N-terminal domain of nuclear IL-1α shows structural similarity to the C-terminal domain of Snf1 and binds to the HAT/core module of the SAGA complex.
Q27003312Nutritional control of growth and development in yeast
Q37312162Ptc1 protein phosphatase 2C contributes to glucose regulation of SNF1/AMP-activated protein kinase (AMPK) in Saccharomyces cerevisiae
Q42628045Sense and antisense transcription are associated with distinct chromatin architectures across genes
Q36574869Snf1-Dependent Transcription Confers Glucose-Induced Decay upon the mRNA Product
Q42254906Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter
Q36217196The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae
Q35970320The spliceosome-activating complex: molecular mechanisms underlying the function of a pleiotropic regulator

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