GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast

scientific article

GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1999PNAS...96.6835B
P356DOI10.1073/PNAS.96.12.6835
P932PMC publication ID22002
P698PubMed publication ID10359799
P5875ResearchGate publication ID12938762

P2093author name stringN Kleckner
S M Burgess
M Ajimura
P2860cites workGenomic sequencingQ24594942
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiaeQ27930541
Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3.Q27931527
A General Method for Identifying Recessive Diploid-Specific Mutations in Saccharomyces cerevisiae, Its Application to the Isolation of Mutants Blocked at Intermediate Stages of Meiotic Prophase and Characterization of a New Gene SAE2Q27931995
Identification of functionally related genes that stimulate early meiotic gene expression in yeast.Q27933381
A meiosis-specific protein kinase, Ime2, is required for the correct timing of DNA replication and for spore formation in yeast meiosisQ27935013
NDT80, a meiosis-specific gene required for exit from pachytene in Saccharomyces cerevisiaeQ27935026
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeastQ27936734
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activationQ27937778
Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivoQ27938598
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiaeQ28131599
Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeastQ28131609
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3pQ28276243
Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiaeQ28306536
Histone acetylation and transcriptional regulatory mechanismsQ29547707
Transcriptional silencing in yeast is associated with reduced nucleosome acetylationQ29618497
Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeastQ33770453
NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiaeQ33780201
A short chromosomal region with major roles in yeast chromosome III meiotic disjunction, recombination and double strand breaksQ33960373
Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivoQ35192911
Initiation of yeast sporulation of partial carbon, nitrogen, or phosphate deprivationQ36310425
Early meiotic transcripts are highly unstable in Saccharomyces cerevisiaeQ36700091
RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiaeQ36744711
A transcriptional cascade governs entry into meiosis in Saccharomyces cerevisiaeQ36777736
Genetic recombination and commitment to meiosis in SaccharomycesQ37456227
Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiaeQ38320449
Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcriptionQ38324867
Mutations in chromatin components suppress a defect of Gcn5 protein in Saccharomyces cerevisiaeQ39574370
Snf1 kinase connects nutritional pathways controlling meiosis in Saccharomyces cerevisiaeQ39575506
Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repressionQ40023668
Transcriptional coactivators in yeast and beyondQ40951549
Initiation of meiosis and sporulation in Saccharomyces cerevisiae requires a novel protein kinase homologueQ42633289
Recombination at work for meiosisQ48018607
Five additional genes in the pulC-O operon of the gram-negative bacterium Klebsiella oxytoca UNF5023 which are required for pullulanase secretionQ48262286
IME1, a positive regulator gene of meiosis in S. cerevisiae.Q52491568
Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeastQ70238280
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)6835-6840
P577publication date1999-06-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleGCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast
P478volume96

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cites work (P2860)
Q39864578Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle.
Q37546830Acetylation of the transcriptional repressor Ume6p allows efficient promoter release and timely induction of the meiotic transient transcription program in yeast
Q39597515Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression
Q37038553Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment
Q34678559Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression
Q38931757Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function
Q37656488From meiosis to postmeiotic events: homologous recombination is obligatory but flexible
Q35917883Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p
Q37468826Genome reprogramming during sporulation.
Q41233273Global position and recruitment of HATs and HDACs in the yeast genome.
Q39891491Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression
Q33967569Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast
Q27934063Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis
Q90715572K-Ras-ERK1/2 accelerates lung cancer cell development via mediating H3K18ac through the MDM2-GCN5-SIRT7 axis
Q39938475Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast.
Q35783683Mechanisms regulating the protein kinases of Saccharomyces cerevisiae
Q27937430Meiosis-specific destruction of the Ume6p repressor by the Cdc20-directed APC/C
Q34508901Meiotic, cryptic, and stable unannotated transcripts: noncoding RNAs add to the epigenetic tool box controlling meiotic development
Q40442851Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus
Q30445180Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis.
Q37820140Physical and functional HAT/HDAC interplay regulates protein acetylation balance
Q37616974Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot.
Q33628559Snf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p
Q24514481TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage
Q27939856The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae.
Q41614744The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer
Q48257104The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation
Q51832741The Rpd3/HDAC complex is present at the URS1 cis-element with hyperacetylated histone H3.
Q26864595The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae
Q41362570The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae
Q27931909The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae
Q27932186The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast
Q35117856Transcriptional regulation of meiosis in budding yeast

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