The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation

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The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation is …
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P356DOI10.4049/JIMMUNOL.1600312
P932PMC publication ID5488716
P698PubMed publication ID28424240

P50authorJianxun SongQ87611460
Donna D ZhangQ89139148
Beixue GaoQ96101692
Qingfei KongQ96101694
Sharon DentQ43106316
Chawon YunQ51015272
P2093author name stringXuemei Li
Deyu Fang
Yiming Wang
Yana Zhang
P2860cites workAcetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA bindingQ24310588
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life spanQ24315083
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complexQ27934812
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activationQ27937778
c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activationQ28186628
Histone acetyltransferases: function, structure, and catalysisQ28204852
Histone acetylation and deacetylation: importance in inflammatory lung diseasesQ28237379
NFAT proteins: key regulators of T-cell development and functionQ28253919
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and JunQ28263918
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivationQ28299905
Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryosQ28593423
Differentiation of effector CD4 T cell populations (*)Q29614838
A new negative control gene for amino acid biosynthesis in Saccharomyces cerevisiae.Q52263803
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.Q53171868
Signals from CD28 induce stable epigenetic modification of the IL-2 promoterQ81621842
Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Q30422849
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse developmentQ30936148
Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexesQ33957284
N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.Q34321405
Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammationQ34533090
MARCH-IX mediates ubiquitination and downregulation of ICAM-1.Q34591916
Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos.Q34865488
The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activationQ34947832
Ubp8 and SAGA regulate Snf1 AMP kinase activity.Q35139409
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesisQ35275796
Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.Q35300659
Myc and SAGA rewire an alternative splicing network during early somatic cell reprogrammingQ35486433
Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.Q36218363
Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 geneQ36369813
GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeastQ36383484
New positive and negative regulators for general control of amino acid biosynthesis in Saccharomyces cerevisiaeQ36914611
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.Q37099446
Transcriptional regulation of IL-2 in health and autoimmunityQ37250679
Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/FasQ37264217
The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cellsQ37311417
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in miceQ37363057
Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammationQ37415675
Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancersQ37659437
USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formationQ39044223
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.Q39559509
GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.Q39600256
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.Q39765588
GCN5 and BCR signalling collaborate to induce pre-mature B cell apoptosis through depletion of ICAD and IAP2 and activation of caspase activitiesQ39974158
T-cell growth factorQ40293133
Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeletonQ41811662
Multiple faces of the SAGA complexQ42045741
Mutations in both the structured domain and N-terminus of histone H2B bypass the requirement for Swi-Snf in yeastQ42664605
The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathwayQ42962015
A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazoneQ46188677
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectK(lysine) acetyltransferase 2AQ21985608
Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2Q21987765
P304page(s)3927-3938
P577publication date2017-04-19
P1433published inJournal of ImmunologyQ3521441
P1476titleThe Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation
P478volume198