Multiple faces of the SAGA complex

scientific article

Multiple faces of the SAGA complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CEB.2010.03.005
P932PMC publication ID2900470
P698PubMed publication ID20363118
P5875ResearchGate publication ID42974971

P2093author name stringSharon Y R Dent
Evangelia Koutelou
Calley L Hirsch
P2860cites workE2F transcriptional activation requires TRRAP and GCN5 cofactorsQ24291353
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivoQ24291710
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencingQ24307408
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progressionQ24307439
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repressionQ24309909
The double-histone-acetyltransferase complex ATAC is essential for mammalian developmentQ24310357
Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding proteinQ24320022
Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substratesQ24522706
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancerQ24528253
Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in DrosophilaQ24537631
Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family membersQ24548063
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-MycQ24554343
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5pQ24596953
Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damageQ24655422
Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.Q25256616
ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complexQ27930121
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.Q27930736
Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activityQ27931763
The deubiquitylation activity of Ubp8 is dependent upon Sgf11 and its association with the SAGA complexQ27932453
Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunitQ27933602
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.Q27933975
SAGA-associated Sgf73p facilitates formation of the preinitiation complex assembly at the promoters either in a HAT-dependent or independent manner in vivoQ27934681
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complexQ27934812
In vivo target of a transcriptional activator revealed by fluorescence resonance energy transferQ27935003
A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulationQ27936635
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA exportQ27936733
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysisQ39927575
In-depth profiling of post-translational modifications on the related transcription factor complexes TFIID and SAGA.Q39949372
SAGA and a novel Drosophila export complex anchor efficient transcription and mRNA export to NPC.Q40045995
Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Q40793485
Global position and recruitment of HATs and HDACs in the yeast genome.Q41233273
SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual systemQ41953553
HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stressQ42563421
Molecular architecture of the S. cerevisiae SAGA complex.Q42631699
The Gcn5 bromodomain of the SAGA complex facilitates cooperative and cross-tail acetylation of nucleosomesQ43148421
Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiaeQ43240899
Site-specific cross-linking of TBP in vivo and in vitro reveals a direct functional interaction with the SAGA subunit Spt3.Q43247301
High-resolution genome-wide mapping of histone modificationsQ47244312
Developmental potential of Gcn5(-/-) embryonic stem cells in vivo and in vitro.Q51988778
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions.Q53577981
H2B Ubiquitylation Acts as a Barrier to Ctk1 Nucleosomal Recruitment Prior to Removal by Ubp8 within a SAGA-Related ComplexQ54998786
Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysinesQ59051030
Expanded lysine acetylation specificity of Gcn5 in native complexesQ74456705
The ATM-related cofactor Tra1 is a component of the purified SAGA complexQ27937594
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activationQ27937778
Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machineryQ27937843
Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylationQ27939467
H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.Q27939759
The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.Q27940177
c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activationQ28186628
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2Q28287716
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60Q28295870
Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-MycQ28575519
Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryosQ28593423
The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosisQ28769333
Genome-wide map of nucleosome acetylation and methylation in yeastQ29614525
Histone ubiquitination: triggering gene activityQ29617523
The SAGA continues: expanding the cellular role of a transcriptional co-activator complexQ30438554
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse developmentQ30936148
Glial cells mediate target layer selection of retinal axons in the developing visual system of Drosophila.Q31965148
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.Q33195734
Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.Q33493740
Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assemblyQ33510906
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degenerationQ33854083
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesisQ35275796
STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferationQ36421035
Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcriptionQ36421102
Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation.Q36908396
Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2.Q36942429
The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.Q36995417
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.Q37164089
Drosophila Ada2b is required for viability and normal histone H3 acetylationQ37493058
Insights into SAGA function during gene expressionQ37553936
Redundant roles for the TFIID and SAGA complexes in global transcriptionQ38311191
The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylationQ38411598
The Sas3p and Gcn5p histone acetyltransferases are recruited to similar genes.Q38606253
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cellsQ39858162
Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activitiesQ39889832
P433issue3
P304page(s)374-382
P577publication date2010-04-02
P1433published inCurrent Opinion in Cell BiologyQ13505682
P1476titleMultiple faces of the SAGA complex
P478volume22

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cites work (P2860)
Q58565095A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell's mass degradation processes
Q97518918A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
Q27670664A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity
Q24314096A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
Q37947760A new chapter in the transcription SAGA.
Q27939024A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.
Q57287889A-to-I mRNA editing in fungi: occurrence, function, and evolution
Q37994551ATAC-king the complexity of SAGA during evolution
Q38758681Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation.
Q64057966Aggregate Filamentous Growth Responses in Yeast
Q100316542An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease
Q41836841Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast
Q90679713Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin
Q44778228C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary function.
Q96136649CRISPR screen in regulatory T cells reveals modulators of Foxp3
Q91361843Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast
Q38018581Chemistry and biology of the ubiquitin signal
Q35748234Chromatin and transcription in yeast
Q37528339Chromatin modifications sequentially enhance ErbB2 expression in ErbB2-positive breast cancers
Q27932566Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes
Q36174818Competitive inhibition can linearize dose-response and generate a linear rectifier
Q26777171Composition of the SAGA complex in plants and its role in controlling gene expression in response to abiotic stresses
Q35450959Conformational flexibility and subunit arrangement of the modular yeast Spt-Ada-Gcn5 acetyltransferase complex
Q33851645Core promoter factor TAF9B regulates neuronal gene expression
Q90663956Determinants of enhancer and promoter activities of regulatory elements
Q90583385Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content
Q35203861Divergence and selectivity of expression-coupled histone modifications in budding yeasts
Q47220947Diversification of the Histone Acetyltransferase GCN5 through Alternative Splicing in Brachypodium distachyon.
Q36124793Drosophila models reveal novel insights into mechanisms underlying neurodegeneration
Q92496123Dynamic and regulated TAF gene expression during mouse embryonic germ cell development
Q96950736Dynamic modules of the coactivator SAGA in eukaryotic transcription
Q35291602Emerging themes in cryptococcal capsule synthesis
Q59813527Epigenetic Factors and Mitochondrial Biology in Yeast: A New Paradigm for the Study of Cancer Metabolism?
Q50487488Four domains of Ada1 form a heterochromatin boundary through different mechanisms.
Q34556013Functional characterization and gene expression profiling of Drosophila melanogaster short dADA2b isoform-containing dSAGA complexes.
Q64071997Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression
Q38238829Functions of SAGA in development and disease
Q34785788Functions of the proteasome on chromatin
Q49216777GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation
Q36076885Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.
Q36643214Genetic manipulation of longevity-related genes as a tool to regulate yeast life span and metabolite production during winemaking.
Q35904632Global reorganization of budding yeast chromosome conformation in different physiological conditions
Q41984790Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe
Q27939770Histone chaperones Nap1 and Vps75 regulate histone acetylation during transcription elongation
Q30371039Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism.
Q35216079Histone modifiers in cancer: friends or foes?
Q92178536Identification of Down-Regulated Proteome in Saccharomyces cerevisiae with the Deletion of Yeast Cathepsin D in Response to Nitrogen Stress
Q42146678Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology.
Q38556492Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast
Q64970940Identification of potential target genes of USP22 via ChIP-seq and RNA-seq analysis in HeLa cells.
Q39162129Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome
Q35476430Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.
Q34206662Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1
Q28538285Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation
Q47315132MPK1/SLT2 Links Multiple Stress Responses with Gene Expression in Budding Yeast by Phosphorylating Tyr1 of the RNAP II CTD.
Q38176851Mechanisms for regulating deubiquitinating enzymes
Q38687124Mechanisms of regulation and diversification of deubiquitylating enzyme function.
Q35486433Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming
Q54473745New insights into the SAGA complex from studies of the Tra1 subunit in budding and fission yeast.
Q90185691Nipped-A regulates the Drosophila circadian clock via histone deubiquitination
Q92008713Noncatalytic Function of a JmjC Domain Protein Disrupts Heterochromatin
Q33554086Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA
Q36155203Nucleosome competition reveals processive acetylation by the SAGA HAT module.
Q42418684Nucleosome eviction in mitosis assists condensin loading and chromosome condensation
Q94503735Pathogenicity-associated protein domains: The fiercely-conserved evolutionary signatures
Q30300394Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module
Q42609408Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation
Q34271399Predicting the fission yeast protein interaction network
Q33879684Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7.
Q93188625Repression of GCN5 expression or activity attenuates c-MYC expression in non-small cell lung cancer
Q33365385Rice Homeodomain Protein WOX11 Recruits a Histone Acetyltransferase Complex to Establish Programs of Cell Proliferation of Crown Root Meristem
Q57072576Roles of Post-translational Modifications in Spinocerebellar Ataxias
Q47790116SAGA Is a General Cofactor for RNA Polymerase II Transcription.
Q40246894SAGA complex mediates the transcriptional up-regulation of antiviral RNA silencing
Q42552805SAGA function in tissue-specific gene expression
Q26795760SGF29 and Sry pathway in hepatocarcinogenesis
Q61207709Separation of a functional deubiquitylating module from the SAGA complex by the proteasome regulatory particle
Q35742827Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex in Plants: Genome Wide Identification, Evolutionary Conservation and Functional Determination
Q27660560Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module
Q57050118Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2
Q38051409Sus1/ENY2: a multitasking protein in eukaryotic gene expression
Q33361972Synergistic action of histone acetyltransferase GCN5 and receptor CLAVATA1 negatively affects ethylene responses in Arabidopsis thaliana
Q92988294Systematical Analysis of the Protein Targets of Lactoferricin B and Histatin-5 Using Yeast Proteome Microarrays
Q48111731TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Q90411371The AREB1 Transcription Factor Influences Histone Acetylation to Regulate Drought Responses and Tolerance in Populus trichocarpa
Q39314583The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation
Q36435140The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila
Q48257104The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation
Q35065482The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae
Q50882135The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.
Q36394676The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination
Q34235677The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.
Q41521346The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast
Q51415405The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally.
Q35910444The Transition of Poised RNA Polymerase II to an Actively Elongating State Is a "Complex" Affair
Q47425675The evolutionarily conserved factor Sus1/ENY2 plays a role in telomere length maintenance
Q38238474The expanding role for chromatin and transcription in polyglutamine disease.
Q39026613The loading of condensin in the context of chromatin.
Q40988704The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.
Q35147589The role of Candida albicans SPT20 in filamentation, biofilm formation and pathogenesis
Q89565511The role of SAGA coactivator complex in snRNA transcription
Q37928313The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses
Q34199540The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements
Q26746231The world of protein acetylation
Q34102709Toward an integrated model of capsule regulation in Cryptococcus neoformans
Q28476564Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
Q33923344Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex
Q57970965Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair
Q39042789Transcription factors that influence RNA polymerases I and II: To what extent is mechanism of action conserved?
Q42133855Transcriptional elongation and mRNA export are coregulated processes.
Q92490294Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA
Q33779463USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein
Q38729273USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.
Q47359149Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer
Q64122383Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury
Q35139409Ubp8 and SAGA regulate Snf1 AMP kinase activity.
Q27931833Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity
Q37696369Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae
Q49911687Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe.