The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.

scientific article published in July 2017

The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2017.06.065
P932PMC publication ID5772774
P698PubMed publication ID28723564

P50authorSharon DentQ43106316
P2093author name stringJian Wang
Yajun Wang
Chawon Yun
Deyu Fang
Chyung-Ru Wang
Hua-Bin Li
Fang Zhao
Qingfei Kong
Yiming Wang
Yana Zhang
Beixue Gao
Xiangping Xu
Yuanming Xu
P2860cites workThe HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitinationQ24320362
Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell lineQ24562381
The transcription factor PLZF directs the effector program of the NKT cell lineageQ24654999
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activationQ27937778
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivationQ28299905
GCN5 and p300 share essential functions during early embryogenesisQ28584780
IL-15 regulates homeostasis and terminal maturation of NKT cellsQ28741430
Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Q30422849
The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineageQ30434352
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelAQ30438310
T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombinationQ33645386
CD1d ligation on human monocytes directly signals rapid NF-kappaB activation and production of bioactive IL-12.Q33920135
Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogenyQ33935873
Regulation of gene expression by transcription factor acetylationQ34058501
Transcriptional control of invariant NKT cell developmentQ34248566
Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.Q34619591
The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activationQ34947832
Mechanisms underlying the effect of vitamin D on the immune systemQ35111151
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies.Q35170088
Betting on NKT and NK cellsQ35745745
Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.Q36218363
Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2RQ36231652
Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation.Q36273261
NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cellsQ36370941
Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8- T cellsQ36380304
Characterization of the early stages of thymic NKT cell developmentQ36402797
The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cellsQ36440062
Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damageQ37292795
Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cellsQ37298525
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cellsQ37310026
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activationQ37358144
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in miceQ37363057
Polyclonal type II natural killer T cells require PLZF and SAP for their development and contribute to CpG-mediated antitumor responseQ37599845
Raising the NKT cell familyQ37688877
Functions of SAGA in development and diseaseQ38238829
The transcriptional programs of iNKT cells.Q38405427
Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors.Q39025344
Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartmentsQ41785389
Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeletonQ41811662
Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cellsQ41861789
Multiple faces of the SAGA complexQ42045741
Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell developmentQ42944908
A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazoneQ46188677
Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cellsQ46251286
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursorsQ46553571
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cellsQ47765721
Developing NKT cells need their calcium.Q51817697
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.Q53171868
P433issue3
P304page(s)600-612
P577publication date2017-07-01
P1433published inCell ReportsQ5058165
P1476titleThe Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.
P478volume20