Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans

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Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans is …
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scholarly articleQ13442814

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P356DOI10.1534/GENETICS.116.192518
P932PMC publication ID5161278
P698PubMed publication ID27707786

P50authorBenoît PinsonQ56084656
Delphine AlbrechtQ57118175
Johanna CeschinQ67226703
P2093author name stringJim Dompierre
Bertrand Daignan-Fornier
Florian Gueniot
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cellsQ24321262
Regulation of chromatin remodeling by inositol polyphosphatesQ24546253
Frequent mutation of histone-modifying genes in non-Hodgkin lymphomaQ24630610
AMPK and PPARdelta agonists are exercise mimeticsQ24652674
ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein KinaseQ27675159
The retinoblastoma protein and cell cycle controlQ27860722
The role of chromatin during transcriptionQ27860995
Chromatin modifications and their functionQ27861067
The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregationQ27930816
Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry.Q27931204
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoterQ27933859
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.Q37309152
Histone H2B ubiquitination: the cancer connectionQ37361776
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.Q37543714
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesisQ38015891
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple EffectsQ38222605
Histone core modifications regulating nucleosome structure and dynamicsQ38260208
Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeastQ38264137
The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cellsQ39334659
The E2 ubiquitin conjugase Rad6 is required for the ArgR/Mcm1 repression of ARG1 transcriptionQ39406784
The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.Q39452101
Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.Q39485644
Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.Q39583815
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinaseQ40370485
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell lineQ40780866
The N-terminal domains of cyclin-dependent kinase inhibitory proteins block the phosphorylation of cdk2/Cyclin E by the CDK-activating kinaseQ40881948
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinaseQ42491855
Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small moleculeQ42871214
Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathwaysQ43106464
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.Q44094473
Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression.Q46693645
The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitinationQ50336173
A rapid permeabilization procedure for accurate quantitative determination of beta-galactosidase activity in yeast cellsQ71693241
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.Q27933975
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.Q27934010
A role for H2B ubiquitylation in DNA replicationQ27934274
Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate.Q27934882
Activation of transcription by metabolic intermediates of the pyrimidine biosynthetic pathwayQ27937077
Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transportersQ27938996
In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalateQ27939351
Getting started with yeastQ28131602
Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphatesQ28215042
Control of cell cycle transcription during G1 and S phasesQ28295030
The genetic landscape of the childhood cancer medulloblastomaQ28301196
Inactivating CUX1 mutations promote tumorigenesisQ28303563
Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysisQ28611260
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylationQ28647313
Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumorsQ28729926
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeastQ29617217
Rad6-dependent ubiquitination of histone H2B in yeastQ29617525
An essential G1 function for cyclin-like proteins in yeastQ29620232
Gene silencing: trans-histone regulatory pathway in chromatinQ30309681
Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversalQ30710761
Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitinationQ33285644
Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II studyQ33404763
To cycle or not to cycle: a critical decision in cancer.Q33957955
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Q34133875
G1 cell-cycle control and cancerQ34368858
Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencingQ34386830
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma developmentQ34493999
Positive feedback in the activation of G1 cyclins in yeastQ34754139
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progressionQ35558616
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylationQ35568111
Approaches to identifying synthetic lethal interactions in cancer.Q35647469
Disruption of Nucleotide Homeostasis by the Antiproliferative Drug 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Monophosphate (AICAR).Q36092969
Identification of aneuploidy-selective antiproliferation compoundsQ36493649
Chromatin challenges during DNA replication and repairQ36744476
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1447-1460
P577publication date2016-10-05
P1433published inGeneticsQ3100575
P1476titleChemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans
P478volume204

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cites work (P2860)
Q90926961A Road Map to Personalizing Targeted Cancer Therapies Using Synthetic Lethality
Q55128561How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases.
Q92760873KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma
Q93380778Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR
Q88551058Multiple chemo-genetic interactions between a toxic metabolite and the ubiquitin pathway in yeast
Q61813974Yeast to Study Human Purine Metabolism Diseases

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