| scholarly article | Q13442814 |
| P2093 | author name string | J. W. Harper | |
| D. W. Goodrich | |||
| L. Connell-Crowley | |||
| P2860 | cites work | Activation of human cyclin-dependent kinases in vitro | Q40241128 |
| The retinoblastoma protein as a fundamental mediator of growth and differentiation signals | Q40406560 | ||
| Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase | Q41080352 | ||
| Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition | Q41335802 | ||
| G1 cyclins control the retinoblastoma gene product growth regulation activity via upstream mechanisms | Q41353026 | ||
| Cyanogen bromide cleavage and proteolytic peptide mapping of proteins immobilized to membranes | Q43687423 | ||
| In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase | Q44175531 | ||
| Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation | Q46219366 | ||
| E2F-induced S phase requires cyclin E. | Q46237378 | ||
| RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila | Q47071369 | ||
| Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16 | Q59082348 | ||
| Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression | Q64378118 | ||
| Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product | Q69389791 | ||
| The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element | Q69535058 | ||
| Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein | Q72801006 | ||
| Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function | Q24311568 | ||
| Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit | Q24312775 | ||
| Growth suppression by p16ink4 requires functional retinoblastoma protein | Q24317567 | ||
| Identification of G1 kinase activity for cdk6, a novel cyclin D partner | Q24324587 | ||
| Identification of discrete structural domains in the retinoblastoma protein. Amino-terminal domain is required for its oligomerization | Q24336303 | ||
| The retinoblastoma protein is phosphorylated on multiple sites by human cdc2 | Q24564605 | ||
| Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase | Q24613134 | ||
| Different roles for cyclins D1 and E in regulation of the G1-to-S transition | Q24651978 | ||
| Human cyclin E, a nuclear protein essential for the G1-to-S phase transition | Q24652527 | ||
| Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates | Q27860715 | ||
| The retinoblastoma protein and cell cycle control | Q27860722 | ||
| Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins | Q28201264 | ||
| Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein | Q28260016 | ||
| Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4 | Q28266936 | ||
| Physical interaction of the retinoblastoma protein with human D cyclins | Q28269103 | ||
| Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F | Q28292616 | ||
| Differential regulation of E2F transactivation by cyclin/cdk2 complexes | Q28612933 | ||
| D-type cyclin-dependent kinase activity in mammalian cells | Q29614966 | ||
| Regulation of retinoblastoma protein functions by ectopic expression of human cyclins | Q29618320 | ||
| Functional interactions of the retinoblastoma protein with mammalian D-type cyclins | Q29618856 | ||
| Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis | Q29619200 | ||
| A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product | Q34091691 | ||
| Inhibition of cyclin-dependent kinases by p21 | Q34447738 | ||
| The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle | Q34504087 | ||
| The retinoblastoma protein is phosphorylated during specific phases of the cell cycle | Q34507572 | ||
| The retinoblastoma protein and the regulation of cell cycling | Q35430130 | ||
| Direct transcriptional repression by pRB and its reversal by specific cyclins | Q36551539 | ||
| Specific enzymatic dephosphorylation of the retinoblastoma protein | Q36659274 | ||
| Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions | Q36775088 | ||
| P433 | issue | 2 | |
| P921 | main subject | phosphorylation | Q242736 |
| retinoblastoma | Q500695 | ||
| P304 | page(s) | 287–301 | |
| P577 | publication date | 1997-02-01 | |
| P1433 | published in | Molecular Biology of the Cell | Q2338259 |
| P1476 | title | Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation | |
| P478 | volume | 8 |
| Q58648366 | Q58648366 |
| Q47128482 | A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size |
| Q36883314 | A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling |
| Q37151025 | A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases. |
| Q36574144 | A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase |
| Q99592641 | A first-in-class CDK4 inhibitor demonstrates in vitro, ex-vivo and in vivo efficacy against ovarian cancer |
| Q42818196 | A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton |
| Q44403127 | A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth |
| Q40105760 | A plant oxylipin, 12-oxo-phytodienoic acid, inhibits proliferation of human breast cancer cells by targeting cyclin D1. |
| Q33701475 | A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF. |
| Q34098906 | A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene |
| Q28297403 | A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2 |
| Q39459140 | Accumulation of cyclin E is not a prerequisite for passage through the restriction point |
| Q37190330 | Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer |
| Q64387135 | Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression |
| Q89949763 | Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells |
| Q31633427 | Altered regulation of cell cycle machinery involved in interleukin-1-induced G(1) and G(2) phase growth arrest of A375S2 human melanoma cells |
| Q44541795 | Analysis of cell cycle regulation by 1-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride (SQMG), an inhibitor of eukaryotic DNA polymerases |
| Q35868505 | Anti-proliferation Effect of Polypeptide Extracted from Scorpion Venom on Human Prostate Cancer Cells in vitro |
| Q33934005 | Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells |
| Q22010625 | Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein |
| Q24554293 | Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription |
| Q24685138 | Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1) |
| Q28567861 | Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells |
| Q35545332 | BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. |
| Q42730827 | Bioinformatic prediction of ultraviolet light mutagenesis sensitivity of human genes and a method for genetically engineering UVB resistance |
| Q61829990 | Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer |
| Q43088666 | CCN5 Expression in mammals. II. Adult rodent tissues |
| Q36510931 | CCN5 expression in mammals : I. Embryonic and fetal tissues of mouse and human |
| Q24799866 | CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells |
| Q24597040 | CCN5: biology and pathophysiology |
| Q28585816 | CDK4 is an essential insulin effector in adipocytes |
| Q41548769 | CDK4/6 inhibition is more active against the glioblastoma proneural subtype |
| Q36796424 | CDK4: A Key Player in the Cell Cycle, Development, and Cancer |
| Q31920947 | COP-1, a member of the CCN family, is a heparin-induced growth arrest specific gene in vascular smooth muscle cells |
| Q93106746 | Calcineurin regulates cyclin D1 stability through dephosphorylation at T286 |
| Q46569253 | Cardiac fibroblasts arrest at the G1/S restriction point in response to interleukin (IL)-1beta. Evidence for IL-1beta-induced hypophosphorylation of the retinoblastoma protein |
| Q42813815 | Catalytic activities of G1 cyclin-dependent kinases and phosphorylation of retinoblastoma protein in mobilized peripheral blood CD34+ hematopoietic progenitor cells |
| Q40744417 | Cdc6 requires anchorage for its expression |
| Q35805158 | Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence |
| Q36702875 | Cell cycle proteins in normal and chemically induced abnormal secondary palate development: a review |
| Q33267031 | Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line |
| Q28504628 | Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization |
| Q46177112 | Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans |
| Q33643357 | Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse |
| Q41732727 | Control of pRB phosphorylation |
| Q43655401 | Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720. |
| Q89456233 | Coupled cycling and regulation of metazoan morphogenesis |
| Q22010574 | Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells |
| Q33957868 | Cumulative effect of phosphorylation of pRB on regulation of E2F activity. |
| Q36796675 | Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells |
| Q40928826 | Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest |
| Q24336871 | Cyclin C/cdk3 promotes Rb-dependent G0 exit |
| Q24554696 | Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo |
| Q34331020 | Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes |
| Q37698862 | Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation |
| Q50285971 | Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes |
| Q50286003 | Cyclin E:CDK2-mediated phosphorylation of RB1 |
| Q37358116 | Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation |
| Q37197923 | Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation. |
| Q77761007 | Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle |
| Q52647690 | Dammarane-type triterpene ginsenoside-Rg18 inhibits human non-small cell lung cancer A549 cell proliferation via G1 phase arrest. |
| Q40408138 | DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry |
| Q39884876 | Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest |
| Q37236908 | Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence |
| Q35132963 | Deregulation of the G1/S-phase control in human testicular germ cell tumours |
| Q42599532 | Deregulation of the RB pathway in human testicular germ cell tumours |
| Q28202769 | Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo |
| Q33957508 | Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts |
| Q40009819 | Differentiation of C2C12 myoblasts expressing lamin A mutated at a site responsible for Emery-Dreifuss muscular dystrophy is improved by inhibition of the MEK-ERK pathway and stimulation of the PI3-kinase pathway |
| Q37697450 | Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). |
| Q38351671 | Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1, E2Fa and E2Fc. |
| Q40080919 | Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2. |
| Q37976277 | Diversity within the pRb pathway: is there a code of conduct? |
| Q40550671 | Docking-dependent regulation of the Rb tumor suppressor protein by Cdk4. |
| Q24338283 | Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells |
| Q37723910 | Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets. |
| Q30426051 | Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma |
| Q36573000 | Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation |
| Q64379575 | E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexes |
| Q39773767 | Effects of endogenous insulin-like growth factor binding protein-3 on cell cycle regulation in breast cancer cells. |
| Q40469370 | Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells. |
| Q46673526 | Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells |
| Q39395200 | Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients |
| Q38908051 | Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence |
| Q36817894 | Expression and localization of Ski determine cell type-specific TGFbeta signaling effects on the cell cycle |
| Q40612848 | Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression |
| Q40052242 | Flavopiridol displays preclinical activity in acute lymphoblastic leukemia |
| Q39574223 | Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes |
| Q24554521 | Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins |
| Q41056387 | G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts |
| Q40148575 | G1 phase cell cycle arrest induced by SARS-CoV 3a protein via the cyclin D3/pRb pathway |
| Q64080120 | G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment |
| Q28248254 | Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK-independent cell cycle arrest |
| Q28263590 | Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism |
| Q40896669 | Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function |
| Q50471675 | Growth arrest of vascular smooth muscle cells in suspension culture using low-acyl gellan gum. |
| Q38310248 | HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1. |
| Q73487322 | HeLa cells are phenotypically limiting in cyclin E/CDK2 for efficient human papillomavirus DNA replication |
| Q39445705 | Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity |
| Q35540170 | How the other half lives, the amino‐terminal domain of the retinoblastoma tumor suppressor protein |
| Q28115953 | IPP5, a novel protein inhibitor of protein phosphatase 1, promotes G1/S progression in a Thr-40-dependent manner |
| Q36535582 | Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response |
| Q28647319 | Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein |
| Q50056326 | Identification of early indicators of altered metabolism in normal development using a rodent model system |
| Q40341917 | Identification of substrates for F-box proteins |
| Q35314377 | Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein |
| Q49071916 | Increased leakiness of the tetracycline-inducible Triple-Op promoter in dividing cells renders it unsuitable for high inducible levels of a dominant negative CDC2aAt gene |
| Q58236963 | Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia |
| Q35899080 | Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma. |
| Q35206804 | Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression |
| Q34946238 | Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation |
| Q56962519 | Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells |
| Q40699814 | Insulin-like growth factor I triggers nuclear accumulation of cyclin D1 in MCF-7S breast cancer cells |
| Q34809313 | Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication |
| Q40916266 | Interaction between the pRb2/p130 C-terminal domain and the N-terminal portion of cyclin D3. |
| Q24310370 | Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein |
| Q38949247 | Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016). |
| Q35222056 | Limited redundancy in phosphorylation of retinoblastoma tumor suppressor protein by cyclin-dependent kinases in acute lymphoblastic leukemia |
| Q34224865 | Mechanisms of action of flavopiridol |
| Q34866982 | Mitogenic Signaling by the gep Oncogene Involves the Upregulation of S-Phase Kinase-Associated Protein 2. |
| Q45314017 | Mitotic G1 phase and G1/S transition |
| Q39664689 | Molecular architecture of the DNA replication origin activation checkpoint |
| Q28486255 | Molecular basis for viral selective replication in cancer cells: activation of CDK2 by adenovirus-induced cyclin E |
| Q35876121 | Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine |
| Q34047944 | Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. |
| Q42030772 | Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain |
| Q34151707 | Murine coronavirus replication induces cell cycle arrest in G0/G1 phase. |
| Q73408342 | Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells |
| Q37216927 | NFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytes |
| Q39104408 | NFκB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation |
| Q77891960 | Negative control elements of the cell cycle in human tumors |
| Q64108542 | Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors |
| Q37109326 | Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases |
| Q47232136 | Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression |
| Q40601469 | Over-expression of cyclin D1 regulates Cdk4 protein synthesis. |
| Q42708398 | Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities |
| Q39650820 | Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development |
| Q38435302 | Overview of major molecular alterations during progression from Barrett's esophagus to esophageal adenocarcinoma. |
| Q35809595 | PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D |
| Q41734805 | Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells |
| Q48806423 | Phospho-Rb mediating cell cycle reentry induces early apoptosis following oxygen-glucose deprivation in rat cortical neurons |
| Q36326276 | Phospho-T356RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck |
| Q24522630 | Phosphorylation of nuclear MyoD is required for its rapid degradation |
| Q43811850 | Phosphorylation of pRb by cyclin D kinase is necessary for development of cardiac hypertrophy |
| Q47683143 | Phosphorylation of the Retinoblastoma Protein in Childhood Acute Lymphoblastic Leukemia |
| Q28346027 | Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block. |
| Q40590523 | Physiological oxidants induce apoptosis and cell cycle arrest in a multidrug-resistant natural killer cell line, NK-YS. |
| Q38103250 | Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function |
| Q52724818 | Protein arginine methylation: an emerging regulator of the cell cycle. |
| Q34792836 | Protein kinases as targets for anticancer agents: from inhibitors to useful drugs |
| Q41005486 | Purification, characterization, and kinetic mechanism of cyclin D1. CDK4, a major target for cell cycle regulation |
| Q34684301 | RB maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells. |
| Q55195011 | RB1 binds and inhibits E2F1/2/3:DP1/2 complexes |
| Q36950978 | RB1, development, and cancer |
| Q55102301 | RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development. |
| Q44368238 | Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells |
| Q34164600 | Ras-dependent cell cycle commitment during G2 phase |
| Q36178390 | Rb/E2F: a two-edged sword in the melanocytic system |
| Q39460727 | Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle |
| Q92106577 | Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective |
| Q35860767 | Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II |
| Q34183761 | Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks |
| Q40882566 | Regulation of transcription by proteins that control the cell cycle |
| Q28647334 | Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes |
| Q34305195 | Retinoblastoma protein partners |
| Q37349093 | Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells |
| Q24537209 | Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4 |
| Q73670518 | S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation |
| Q40486252 | S100B increases proliferation in PC12 neuronal cells and reduces their responsiveness to nerve growth factor via Akt activation. |
| Q40635576 | SV40 large T antigen promotes dephosphorylation of p130. |
| Q43548171 | Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. |
| Q38334543 | Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides |
| Q38104238 | Signaling through cyclin D-dependent kinases |
| Q81626719 | Single cell analysis of G1 check points-the relationship between the restriction point and phosphorylation of pRb |
| Q40794499 | Site-specific and temporally-regulated retinoblastoma protein dephosphorylation by protein phosphatase type 1. |
| Q34995472 | Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity |
| Q24299116 | Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release |
| Q35236730 | T160‐phosphorylated CDK2 defines threshold for HGF dependent proliferation in primary hepatocytes |
| Q40935957 | TGF-beta1-mediated hypertrophy involves inhibiting pRB phosphorylation by blocking activation of cyclin E kinase |
| Q34162501 | Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers |
| Q37520483 | Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells |
| Q40370724 | The Drosophila cyclin D-Cdk4 complex promotes cellular growth |
| Q36721355 | The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments |
| Q36520728 | The RB tumor suppressor positively regulates transcription of the anti-angiogenic protein NOL7 |
| Q52390983 | The Temporal Regulation of S Phase Proteins During G1. |
| Q33689187 | The antiviral cytokine interferon-gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation |
| Q36685541 | The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells |
| Q51750855 | The cyclin kinase inhibitor p57kip2 regulates TGF-beta-induced compensatory tubular hypertrophy: effect of the immunomodulator AS101. |
| Q34178106 | The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells |
| Q39943823 | The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F. |
| Q47994028 | The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins. |
| Q33472952 | The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells |
| Q38818832 | The oncogenetic role of stanniocalcin 1 in lung adenocarcinoma: a promising serum candidate biomarker for tracking lung adenocarcinoma progression |
| Q33964019 | The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues |
| Q41678479 | The restriction point and control of cell proliferation |
| Q33562001 | The retinoblastoma tumor-suppressor gene, the exception that proves the rule |
| Q34149070 | The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8 |
| Q43725627 | The role of Thr160 phosphorylation of Cdk2 in substrate recognition |
| Q40221897 | The tumor-growth inhibitory activity of flavanone and 2'-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs |
| Q41432248 | Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells |
| Q55470130 | Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. |
| Q77346750 | Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795 |
| Q34698674 | Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1). |
| Q90205188 | Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1 |
| Q34924201 | WT1 promotes cell proliferation in non-small cell lung cancer cell lines through up-regulating cyclin D1 and p-pRb in vitro and in vivo |
| Q24307568 | c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells |
| Q41828430 | p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor |
| Q38466090 | p53, p21, Rb, and MDM2 proteins in tongue carcinoma from patients < 35 versus > 75 years. |
| Q74234874 | pRb and Cdk regulation by N-(4-hydroxyphenyl)retinamide |
| Q40922387 | pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk) 2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells |
| Q100940861 | siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation |
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