Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

scientific article published on 8 September 2016

Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDDIS.2016.155
P932PMC publication ID5059850
P698PubMed publication ID27607583

P2093author name stringKexin Chen
Yong-Guang Yang
Qi Gao
Yang Zheng
Lu Gao
P2860cites workMechanisms, Pathophysiology, and Therapy of Arterial StiffnessQ22306395
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunctionQ24292963
Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptakeQ24302047
Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factorsQ24633525
CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1Q28251463
CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interestQ28270624
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylationQ28647313
Age-dependent impairment of angiogenesisQ31936271
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesisQ33896683
The Rb/E2F pathway and cancerQ34189004
The essence of senescenceQ34288983
Cellular senescence in cancer and agingQ34581486
The RB and p53 pathways in cancerQ34804764
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular diseaseQ35039895
The intersection between aging and cardiovascular diseaseQ36006533
Cellular senescence in vivo: its relevance in ageing and cardiovascular disease.Q36170065
Telomerase Therapy to Reverse Cardiovascular SenescenceQ36337799
RB and cell cycle progressionQ36579245
Exposure to high or low glucose levels accelerates the appearance of markers of endothelial cell senescence and induces dysregulation of nitric oxide synthaseQ37270908
Vascular endothelial senescence: from mechanisms to pathophysiology.Q37335759
Generation of an immortalized murine brain microvascular endothelial cell line as an in vitro blood brain barrier modelQ38041049
Defining vascular aging and cardiovascular riskQ38057620
Role of thrombospondin-1-derived peptide, 4N1K, in FGF-2-induced angiogenesisQ40922219
Age-related expression of renal thrombospondin 1 mRNA in F344 rats: resemblance to diabetes-induced expression in obese Zucker ratsQ40966923
Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinaseQ42075557
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.Q43652228
Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cellsQ44044681
Expression of CD47/integrin-associated protein induces death of cultured cerebral cortical neuronsQ44719553
Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunctionQ44965792
p53 Deficiency leads to compensatory up-regulation of p16INK4aQ46110603
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)e2368
P577publication date2016-09-08
P1433published inCell Death and DiseaseQ2197222
P1476titleThrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells
P478volume7

Reverse relations

cites work (P2860)
Q38739380Arterial ageing: from endothelial dysfunction to vascular calcification.
Q90218852CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism
Q33618348CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis
Q55413755Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat.
Q64267428Current progress in the inflammatory background of angiogenesis in gynecological cancers
Q64274322Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling
Q91812198Exosomal Thrombospondin-1 Disrupts the Integrity of Endothelial Intercellular Junctions to Facilitate Breast Cancer Cell Metastasis
Q93131804HDAC6 Suppresses Let-7i-5p to Elicit TSP1/CD47-Mediated Anti-Tumorigenesis and Phagocytosis of Hepatocellular Carcinoma
Q50019794Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions
Q98292025Identification and Characterization of the Copy Number Dosage-Sensitive Genes in Colorectal Cancer
Q89965774NK Cell-Based Immune Checkpoint Inhibition
Q92295200Natural Killer Cell Recruitment and Activation Are Regulated by CD47 Expression in the Tumor Microenvironment
Q38656989Regulation of cellular redox signaling by matricellular proteins in vascular biology, immunology, and cancer
Q93173234Role of thrombospondin‑1 and thrombospondin‑2 in cardiovascular diseases (Review)
Q92397686TSP1 ameliorates age-related macular degeneration by regulating the STAT3-iNOS signaling pathway
Q46282340The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.
Q38648723Thrombospondin-1, free radicals, and the coronary microcirculation: the aging conundrum
Q92545457miR‑20b inhibits the senescence of human umbilical vein endothelial cells through regulating the Wnt/β‑catenin pathway via the TXNIP/NLRP3 axis