Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function

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Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049903276
P356DOI10.1038/SJ.ONC.1203332
P698PubMed publication ID10698526
P5875ResearchGate publication ID12616196

P2093author name stringCooke C
Goodrich DW
Barrientes S
P2860cites workThe amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processingQ24306341
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycleQ24319785
Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.Q24523723
Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7Q27748910
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4Q28266936
Physical interaction of the retinoblastoma protein with human D cyclinsQ28269103
Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sitesQ28278266
70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb. Identification of a novel region of pRb-mediating protein interactionQ28297406
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motifQ28609358
Repression of human heat shock factor 1 activity at control temperature by phosphorylationQ28609651
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylationQ28647313
Cancer cell cyclesQ29547756
Regulation of retinoblastoma protein functions by ectopic expression of human cyclinsQ29618320
Functional interactions of the retinoblastoma protein with mammalian D-type cyclinsQ29618856
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sitesQ33706825
Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Q33957868
Transformation of mammalian cells with genes from procaryotes and eucaryotesQ34030262
The retinoblastoma gene product regulates progression through the G1 phase of the cell cycleQ34504087
The retinoblastoma protein is phosphorylated during specific phases of the cell cycleQ34507572
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growthQ35187190
Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progressionQ35206804
cdc2 phosphorylation is required for its interaction with cyclin.Q35933286
Direct transcriptional repression by pRB and its reversal by specific cyclinsQ36551539
Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylationQ36573000
Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression.Q36574115
The retinoblastoma gene and cell growth controlQ37936127
Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerizationQ38329336
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.Q40789796
pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.Q40995683
Identification of a growth suppression domain within the retinoblastoma gene productQ41619792
Evidence of a functional interaction between serine 3 and serine 25 Mos phosphorylation sites. A dominant inhibitory role of serine 25 phosphorylation on Mos protein kinaseQ42829078
In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinaseQ44175531
Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiationQ46219366
The retinoblastoma protein region required for interaction with the E2F transcription factor includes the T/E1A binding and carboxy-terminal sequencesQ46784209
Mutation of serine 90 to glutamic acid mimics phosphorylation of bovine prolactin.Q50756372
Cyclin E-induced S phase without activation of the pRb/E2F pathway.Q60200141
Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene productQ69389791
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory elementQ69535058
S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylationQ73670518
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
retinoblastomaQ500695
P304page(s)562-570
P577publication date2000-01-01
P1433published inOncogeneQ1568657
P1476titleGlutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function
P478volume19

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cites work (P2860)
Q33614054Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction
Q51065936Computational identification of post-translational modification-based nuclear import regulations by characterizing nuclear localization signal-import receptor interaction.
Q83960761Dephosphorylation of Rb (Thr-821) in response to cell stress
Q39297101Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition
Q35540170How the other half lives, the amino‐terminal domain of the retinoblastoma tumor suppressor protein
Q42649115Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.
Q35222056Limited redundancy in phosphorylation of retinoblastoma tumor suppressor protein by cyclin-dependent kinases in acute lymphoblastic leukemia
Q37410628Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.
Q36950978RB1, development, and cancer
Q36585506RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3
Q39331719Regulation of epithelial differentiation and proliferation by the stroma: a role for the retinoblastoma protein
Q35378176Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis
Q36151923Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?
Q30357109The N Terminus of the Retinoblastoma Protein Inhibits DNA Replication via a Bipartite Mechanism Disrupted in Partially Penetrant Retinoblastomas.
Q35488900The retinoblastoma tumor suppressor promotes efficient human cytomegalovirus lytic replication
Q33562001The retinoblastoma tumor-suppressor gene, the exception that proves the rule
Q27319518Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.

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