Epigenomics and breast cancer

scientific article published on December 2008

Epigenomics and breast cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.2217/14622416.9.12.1879
P932PMC publication ID2633440
P698PubMed publication ID19072646
P5875ResearchGate publication ID23653551

P2093author name stringSaraswati Sukumar
Pang-Kuo Lo
P2860cites workThe Hallmarks of CancerQ221226
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylationQ22003769
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomasQ22008613
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?Q22251049
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication fociQ22254582
HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cellsQ24291505
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiationQ24293278
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase familyQ24294179
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencingQ24294291
HDAC6 is a microtubule-associated deacetylaseQ24298013
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repressionQ24300386
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOFQ24305335
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancerQ24309649
MethyLight: a high-throughput assay to measure DNA methylationQ24515378
Comprehensive analysis of CpG islands in human chromosomes 21 and 22Q24531622
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcriptionQ24534441
The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3aQ24544000
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strandsQ24562877
Telomere shortening and apoptosis in telomerase-inhibited human tumor cellsQ24598974
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3Q24599788
The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomesQ24602177
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNAQ24621648
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
Genome-wide maps of chromatin state in pluripotent and lineage-committed cellsQ24632506
Histone sumoylation is associated with transcriptional repressionQ24656259
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsQ24672969
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferaseQ24678267
Comparative isoschizomer profiling of cytosine methylation: the HELP assayQ24685607
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteinsQ24685694
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomainsQ27641772
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.Q53666037
Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms.Q54790226
Moving AHEAD with an international human epigenome project.Q55050360
The fundamental role of epigenetic events in cancerQ56421597
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4aQ57277034
Circulating Methylated DNA: A New Generation of Tumor MarkersQ61925524
Chromosomal Instability and Tumors Promoted by DNA HypomethylationQ63253103
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cellsQ72386166
NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancersQ72992695
Epigenetic silencing of maspin gene expression in human breast cancersQ73527270
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylationQ73715187
Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCRQ73852496
Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomasQ73963453
Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancerQ74088944
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangementsQ74578917
Hypomethylation of pericentromeric DNA in breast adenocarcinomasQ77132854
Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumorsQ77556929
Global DNA hypomethylation in breast carcinoma: correlation with prognostic factors and tumor progressionQ77916758
Methylation profiling of CpG islands in human breast cancer cellsQ78015848
Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survivalQ78632811
DNA methylation in serum of breast cancer patients: an independent prognostic markerQ79317164
HDAC inhibitors overcome first hurdleQ79520691
Association of GSTP1 CpG islands hypermethylation with poor prognosis in human breast cancersQ79768604
Epigenetics and cancerQ80824706
DNA methylation analysis by pyrosequencingQ81247006
Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cellsQ34124417
Acetylation of beta-catenin by CREB-binding protein (CBP).Q34125251
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancerQ34126908
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cellsQ34144912
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.Q34225624
Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylomeQ34231008
Stem cells and cancer; the polycomb connectionQ34341685
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferasesQ34343364
Stat3 dimerization regulated by reversible acetylation of a single lysine residueQ34384817
Co-evolution of X-chromosome inactivation and imprinting in mammalsQ34409829
Evidence for an instructive mechanism of de novo methylation in cancer cells.Q34489258
COBRA: a sensitive and quantitative DNA methylation assayQ34630070
The many faces of histone lysine methylationQ34688382
DNA hypomethylation leads to elevated mutation ratesQ34752442
DNA methylation and breast carcinogenesis.Q34770599
Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancerQ34774614
Genome-wide promoter analysis uncovers portions of the cancer methylome.Q35008027
Diagnosis and Management of Central Nervous System Metastases from Breast CancerQ35552601
Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor.Q35563726
Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancerQ35605804
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancerQ35759154
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.Q35804605
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesisQ35959363
Sin3: a flexible regulator of global gene expression and genome stability.Q35964130
Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defectsQ35973630
Breast cancer: origins and evolutionQ36099434
Prospects: histone deacetylase inhibitorsQ36223192
Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acidQ36303956
Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor riskQ36343107
DNA methyltransferases: facts, clues, mysteries.Q36434817
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell linesQ36465214
Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequencesQ36475874
Dual targeting of epigenetic therapy in cancerQ36576206
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteinsQ27860456
Worms gang up on bacteriaQ27860588
High-resolution profiling of histone methylations in the human genomeQ27860906
The genomic landscapes of human breast and colorectal cancersQ27861078
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylationQ27937996
Histone demethylation by a family of JmjC domain-containing proteinsQ27939224
Role of histone H3 lysine 27 methylation in Polycomb-group silencingQ28131795
Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene familyQ28138517
Deacetylation of p53 modulates its effect on cell growth and apoptosisQ28138967
TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancersQ28139273
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promotersQ28140428
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylationQ28143634
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatinQ28187783
CoREST is an integral component of the CoREST- human histone deacetylase complexQ28199886
DNA methylation: a profile of methods and applicationsQ28202469
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamilyQ28207095
N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein KaisoQ28207325
Bromodomain: an acetyl-lysine binding domainQ28209708
A gene hypermethylation profile of human cancerQ28213253
Duration of nuclear NF-kappaB action regulated by reversible acetylationQ28215080
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancerQ28239595
Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancerQ28253941
Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevisQ28263661
Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancerQ28269763
Regulation of LSD1 histone demethylase activity by its associated factorsQ28270391
Cancer genes and the pathways they controlQ28275089
The cancer epigenome--components and functional correlatesQ28278109
Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assemblyQ28278522
The epigenomics of cancerQ28289975
Genome regulation by polycomb and trithorax proteinsQ28289984
Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancerQ28291617
Molecular definition of breast tumor heterogeneityQ28292256
Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosisQ28294866
High-resolution genome-wide mapping of histone modificationsQ47244312
Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancerQ47255065
Mapping of ER gene CpG island methylation-specific polymerase chain reaction.Q47945083
Regulation and function of DNA methylation in vertebratesQ48034319
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancersQ48277606
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGsQ48289947
Imprinting and the epigenetic asymmetry between parental genomesQ48881402
DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.Q50320380
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.Q52564601
Two-color quantitative multiplex methylation-specific PCR.Q53348571
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.Q53429823
Methylation-specific digital karyotypingQ28296362
Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancersQ28343483
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiaeQ28343956
Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1Q28575665
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9Q28594945
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domainsQ28609779
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3Q28609869
MicroRNA biogenesis: coordinated cropping and dicingQ29547496
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcriptionQ29547568
Genomic maps and comparative analysis of histone modifications in human and mouseQ29614418
The diverse functions of histone lysine methylationQ29614523
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancerQ29615066
Cancer epigenomics: DNA methylomes and histone-modification mapsQ29615524
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancerQ29615649
Anticancer activities of histone deacetylase inhibitorsQ29616624
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genomeQ29616819
The history of cancer epigeneticsQ29617273
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosomeQ29618064
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cellsQ29618090
Hypomethylation distinguishes genes of some human cancers from their normal counterpartsQ29619217
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expressionQ29619380
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancerQ29622925
Effector proteins for methylated histones: an expanding familyQ30437185
CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancerQ33235269
A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancerQ33267359
Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genesQ33335165
Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?Q33864653
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.Q33888431
Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitorsQ33935153
Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylationQ33988438
Chasing the cancer demonQ34090719
Histone deacetylase inhibitors: signalling towards p21cip1/waf1.Q36782509
Cell type-specific DNA methylation patterns in the human breastQ36869180
Retinoids in biological control and cancerQ36954461
Histone deacetylase inhibitors for cancer therapy.Q36999619
Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasisQ38341003
Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS).Q39538478
Inhibition of histone deacetylase suppresses EGF signaling pathways by destabilizing EGFR mRNA in ER-negative human breast cancer cellsQ39953544
Anti-estrogenic actions of histone deacetylase inhibitors in MCF-7 breast cancer cellsQ40043213
Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.Q40093675
Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrantQ40192741
A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancerQ40236523
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancerQ40259898
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexesQ40266897
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.Q40269139
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin stateQ40296469
Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.Q40311505
Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell deathQ40386567
Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activityQ40401113
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.Q40446699
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancerQ40490715
Preferential response of cancer cells to zebularine.Q40523300
Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen.Q40550191
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.Q40614411
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNAQ40617392
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone BQ40623032
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylationQ40690782
DNA damage-induced translocation of the Werner helicase is regulated by acetylationQ40696914
Acetylation of importin-alpha nuclear import factors by CBP/p300.Q40881413
Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cellsQ40891228
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryoteQ40903819
DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of 5-aza-2'-deoxycytidineQ40930861
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplificationQ40951949
MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.Q41999930
Cellular differentiation, cytidine analogs and DNA methylationQ42242732
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cellsQ42808496
How epigenetics integrates nuclear functions. Workshop on epigenetics and chromatin: transcriptional regulation and beyondQ43205547
Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibitionQ43561182
Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancersQ43578083
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancerQ43590545
Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomasQ43670890
Hypermethylation leads to silencing of the SYK gene in human breast cancer.Q43675322
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.Q43755864
Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.Q43787473
CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression.Q43787489
Glypican-3 expression is silenced in human breast cancerQ43796931
Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma.Q44259986
Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinomaQ44302057
Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapyQ44435155
Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.Q44615045
Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines.Q44653608
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosisQ44800956
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.Q44816904
Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens.Q44836071
Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluidQ45191819
Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer riskQ45238905
Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.Q46689478
P433issue12
P921main subjectbreast cancerQ128581
P304page(s)1879-1902
P577publication date2008-12-01
P1433published inPharmacogenomicsQ15724625
P1476titleEpigenomics and breast cancer
P478volume9

Reverse relations

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