SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

scientific article

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins is …
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scholarly articleQ13442814

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P356DOI10.1101/GAD.973302
P3181OpenCitations bibliographic resource ID1137713
P932PMC publication ID152359
P698PubMed publication ID11959841
P5875ResearchGate publication ID11407285

P2093author name stringFrank J Rauscher
Kasirajan Ayyanathan
Gerd G Maul
David C Schultz
Dmitri Negorev
P2860cites workKAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.Q22010040
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locusQ43703042
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomesQ43820588
Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X InactivationQ43826425
Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genesQ51089777
ReCoGnizing methylated DNAQ74102806
Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactionsQ22011176
Translating the Histone CodeQ22065840
Regulation of chromatin structure by site-specific histone H3 methyltransferasesQ24290115
Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domainsQ24290873
KAP-1, a novel corepressor for the highly conserved KRAB repression domainQ24317676
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppressionQ24321439
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4Q24536072
Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essentialQ24551928
Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRDQ24602561
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formationQ24672514
A family of chromatin remodeling factors related to Williams syndrome transcription factorQ24673669
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tailQ27638012
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteinsQ27860456
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domainQ27860477
The language of covalent histone modificationsQ27860931
COMPASS: a complex of proteins associated with a trithorax-related SET domain proteinQ27931344
SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processesQ27939597
Regulation of transcription by a protein methyltransferaseQ28138085
Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domainQ28140601
Signaling to chromatin through histone modificationsQ28142598
Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybridsQ28144658
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3Q28214048
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiaeQ28343956
A homeotic mutation in the trithorax SET domain impedes histone bindingQ28349462
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assemblyQ29614718
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stabilityQ29620365
Rb targets histone H3 methylation and HP1 to promotersQ29620452
Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundariesQ29622865
Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in TetrahymenaQ30304568
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3.Q30307942
An embarrassment of niches: the many covalent modifications of histones in transcriptional regulation.Q34290234
Nuclear redistribution of BRCA1 during viral infectionQ41006459
Analysis of chromatin structure by in vivo formaldehyde cross-linking.Q41132202
A histone H3 methyltransferase controls DNA methylation in Neurospora crassaQ42664087
Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogeneQ42834438
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectgene silencingQ1431332
P304page(s)919-32
P577publication date2002-04-15
P1433published inGenes & DevelopmentQ1524533
P1476titleSETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
P478volume16

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Q33514240Identification of a functional network of human epigenetic silencing factors
Q42801796Identification of a novel Krüppel-associated box domain protein, Krim-1, that interacts with c-Myc and inhibits its oncogenic activity
Q52020343Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing
Q48311167Identifying Novel Enhancer Elements with CRISPR-Based Screens.
Q47389543Impact of Xist RNA on chromatin modifications and transcriptional silencing maintenance at different stages of imprinted X chromosome inactivation in vole Microtus levis.
Q35534127In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
Q24529080In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation
Q37460085In vivo gene regulation using tetracycline-regulatable systems
Q36558145Inactivation of a human kinetochore by specific targeting of chromatin modifiers
Q33637083Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells
Q38831555Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
Q33743831Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jκ.
Q58797765Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
Q38610600Inhibition of transcription and DNA replication by the papillomavirus E8-E2C protein is mediated by interaction with corepressor molecules
Q42182620Interaction of SET domains with histones and nucleic acid structures in active chromatin.
Q24300478Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways
Q84071295Interactions of Transcription Factors with Chromatin
Q28680737Interplay between chromatin state, regulator binding, and regulatory motifs in six human cell types
Q33994811Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements
Q36788865Intersection of nuclear receptors and the proteasome on the epigenetic landscape
Q33652604Introduction--Epiphanies in epigenetics.
Q40392178Involvement of HP1alpha protein in irreversible transcriptional inactivation by antiestrogens in breast cancer cells.
Q33883423Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.
Q39173734Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation
Q34181321Isoform-specific Intermolecular Disulfide Bond Formation of Heterochromatin Protein 1 (HP1)
Q64236643It Takes a Team: A Gain-of-function Story of p53-R249S
Q35668901Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart
Q35532757KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair
Q36434260KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification
Q52718550KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners
Q57549469KAP1 facilitates reinstatement of heterochromatin after DNA replication
Q42657934KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5.
Q92708333KAP1 is an antiparallel dimer with a functional asymmetry
Q34979737KAP1 promotes proliferation and metastatic progression of breast cancer cells
Q37886421KAP1 protein: an enigmatic master regulator of the genome
Q27319505KAP1 regulates gene networks controlling T-cell development and responsiveness.
Q36931943KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.
Q89754582KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity
Q26822740KAPtain in charge of multiple missions: Emerging roles of KAP1
Q34568487KRAB can repress lentivirus proviral transcription independently of integration site
Q46327518KRAB zinc finger proteins.
Q38920949KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks
Q43078740KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies.
Q37065382KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions.
Q24792646KRAB-containing zinc-finger repressor proteins
Q39859206KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.
Q96031505KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
Q28473103KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading
Q43079558Kaposi's Sarcoma-Associated Herpesvirus Kaposin B Induces Unique Monophosphorylation of STAT3 at Serine 727 and MK2-Mediated Inactivation of the STAT3 Transcriptional Repressor TRIM28
Q33744019Kaposi's sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency
Q41854713Kinetics and epigenetics of retroviral silencing in mouse embryonic stem cells defined by deletion of the D4Z4 element
Q38201977Kruppel-associated box (KRAB) proteins in the adaptive immune system
Q37317681Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase
Q35844907LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes
Q42103716LINEing germ and embryonic stem cells' silencing of retrotransposons
Q33791296Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1.
Q35875136Lineage-specific expansion of KRAB zinc-finger transcription factor genes: implications for the evolution of vertebrate regulatory networks
Q37300571Linking Heterochromatin Protein 1 (HP1) to cancer progression
Q48121278LncRNA HOTAIR promotes cell migration and invasion by regulating MKL1 via inhibition miR206 expression in HeLa cells.
Q58787366Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene
Q34977115Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer
Q37618942Loss of maternal Trim28 causes male-predominant early embryonic lethality
Q33994806Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency
Q24669780Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome
Q36699534Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.
Q24675122Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association
Q26996661MBD2 and MBD3: elusive functions and mechanisms
Q34016183MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
Q35092329MHC class II regulation by epigenetic agents and microRNAs
Q26765418Maintaining memory of silencing at imprinted differentially methylated regions
Q99415024MasterPATH: network analysis of functional genomics screening data
Q35987178Maternal Setdb1 Is Required for Meiotic Progression and Preimplantation Development in Mouse
Q24338285Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet
Q53587019Meisetz and the birth of the KRAB motif
Q34747001Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation
Q28278522Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly
Q38451083Methyl-CpG-binding domain proteins: readers of the epigenome
Q30309950Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena
Q36557362Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma.
Q46677250MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1.
Q41936508Microduplication of Xp11.23p11.3 with effects on cognition, behavior, and craniofacial development
Q36956834Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt).
Q37845655Molecular coupling of DNA methylation and histone methylation
Q42525446Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation
Q41902696Multiparameter functional diversity of human C2H2 zinc finger proteins.
Q37152690Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster
Q24532155Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation
Q45183912Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution
Q24547306NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression
Q42690788Neuroepigenetic mechanisms in disease
Q44491438Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations
Q36412174Nuclear domain 10-associated proteins recognize and segregate intranuclear DNA/protein complexes to negate gene expression
Q34189419Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells
Q91644556On the relations of phase separation and Hi-C maps to epigenetics
Q38102573On your histone mark, SET, methylate!
Q34759375Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair
Q37336939Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression
Q55039489PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.
Q36206842PEG3 Interacts with KAP1 through KRAB-A.
Q24303619PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
Q43040885PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.
Q40329969PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies
Q42612084PPAR-gamma Signaling Crosstalk in Mesenchymal Stem Cells
Q28247014PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing
Q34116913PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure
Q26995208Partners in crime: The role of tandem modules in gene transcription
Q34270424Paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor
Q42182193Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response
Q33347938Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.
Q36929141Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1α (HP1α) with Heterochromatin
Q40044888Physical and functional interactions between STAT3 and KAP1.
Q37996525Pluripotency and Nuclear Reprogramming
Q34297995Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1α at chromatin
Q38725574Position-effect variegation revisited: HUSHing up heterochromatin in human cells.
Q99407750Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons
Q36540170Primer binding site-dependent restriction of murine leukemia virus requires HP1 binding by TRIM28.
Q41077260Profile of histone lysine methylation across transcribed mammalian chromatin
Q35661433Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster
Q39737989Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.
Q34139275Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase
Q51023875Purification of histone methyltransferases from HeLa cells
Q59323656RETRACTED ARTICLE: DDB1 and Cul4 are necessary for gene silencing and heterochromatin formation at pericentromeric regions in Neurospora
Q91942270Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila
Q21563368Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength
Q38022419Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
Q37106147Recruitment and Biological Consequences of Histone Modification of H3K27me3 and H3K9me3
Q35167221Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise
Q42817808Regulated nuclear entry of over‐expressed Setdb1
Q24671965Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
Q34335413Regulation and function of the peg3 imprinted domain
Q60960055Regulation of Chromatin Structure During Neural Development
Q24337687Regulation of E2F1 function by the nuclear corepressor KAP1
Q28659478Regulation of Mouse Retroelement MuERV-L/MERVL Expression by REX1 and Epigenetic Control of Stem Cell Potency
Q28585312Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
Q33707691Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment.
Q35260579Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
Q48771662Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington's disease.
Q28067125Repair of DNA Double-Strand Breaks in Heterochromatin
Q39057569Replication stress and chromatin context link ATM activation to a role in DNA replication.
Q39713121Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis
Q36215800Reprogramming cell fate with a genome-scale library of artificial transcription factors.
Q40066661Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
Q39110529Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation
Q38787077Role of genome guardian proteins in transcriptional elongation.
Q37769114Role of histone methylation and demethylation in adipogenesis and obesity.
Q36639797Role of several histone lysine methyltransferases in tumor development
Q37961784Roles of RNAi in Chromatin Regulation and Epigenetic Inheritance
Q37615671SET for life: biochemical activities and biological functions of SET domain-containing proteins
Q34427470SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.
Q92570251SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
Q58596731SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice
Q35097426SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway
Q37024818SETDB1 mediated FosB expression increases the cell proliferation rate during anticancer drug therapy
Q90317043SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation
Q36032490SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells
Q92676703SETDB1 modulates the differentiation of both the crystal cells and the lamellocytes in Drosophila
Q94562316SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression
Q64085932SETDB1 regulates SMAD7 expression for breast cancer metastasis
Q35709996SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells.
Q91259720SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
Q64063071SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
Q33785287SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination
Q33854004SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line
Q36997854SUMO wrestling with Ras.
Q39962765SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing
Q24307960SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
Q50287033SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)
Q34174809Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1.
Q37426752SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state
Q30495175Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B.
Q34464546Setdb1 is required for myogenic differentiation of C2C12 myoblast cells via maintenance of MyoD expression
Q34511024Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice
Q34368215Should I stay or should I go: protection and maintenance of DNA methylation at imprinted genes.
Q37252690Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.
Q26775416Signal transducer and activator of transcription 3 regulation by novel binding partners
Q37827337Silencing chromatin: comparing modes and mechanisms
Q39119025Silencing of endogenous retroviruses by heterochromatin
Q47831063Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.
Q36926242Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells
Q34107315Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.
Q55002950Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs.
Q35964130Sin3: a flexible regulator of global gene expression and genome stability.
Q38552741Sound of silence: the properties and functions of repressive Lys methyltransferases.
Q40081931Spatial distribution of histone methylation during MHC class II expression
Q26782206Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family
Q34531990Step out of the groove: epigenetic gene control systems and engineered transcription factors
Q24646957Structural basis for the product specificity of histone lysine methyltransferases
Q27643095Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin
Q37829702Structure and Function of Histone H3 Lysine 9 Methyltransferases and Demethylases
Q27639757Structure and catalytic mechanism of a SET domain protein methyltransferase
Q24646827Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase
Q34126327Substitutions in the Amino-Terminal Tail of Neurospora Histone H3 Have Varied Effects on DNA Methylation
Q40504274Substrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase
Q38116514Sumoylation at the Host-Pathogen Interface
Q40171341Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain
Q36478099Suppression and recovery of BRCA1-mediated transcription by HP1γ via modulation of promoter occupancy
Q98945200Synthetic immunomodulation with a CRISPR super-repressor in vivo
Q47252056Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease
Q79374289TEL/ETV6 binds to corepressor KAP1 via the HLH domain
Q28581440TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77
Q28590323TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids
Q43123488TRIM28 Controls Genomic Imprinting through Distinct Mechanisms during and after Early Genome-wide Reprogramming
Q26796250TRIM28 as a novel transcriptional elongation factor
Q38827071TRIM28 as an independent prognostic marker plays critical roles in glioma progression
Q91166006TRIM28 down-regulation on methylation imprints in bovine preimplantation embryos
Q48025310TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming
Q37349418TRIM28 is essential for erythroblast differentiation in the mouse
Q28513391TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues
Q36471255TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells
Q36841416TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cells
Q54312343TRIM28 prevents autoinflammatory T cell development in vivo
Q39067871TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells.
Q36660136TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
Q49268679TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency
Q38742837TRIMming p53's anticancer activity
Q38170892TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity
Q90707206Targeting DNA repair in cancer: current state and novel approaches
Q39175486Targeting histone methylation for colorectal cancer
Q37384129Telomeres, histone code, and DNA damage response
Q89638553The "ART" of Epigenetics in Melanoma: From histone "Alterations, to Resistance and Therapies"
Q36972711The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation
Q39026954The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is responsible for its weaker transcriptional repressor activity compared to human ZNF10/Kox1.
Q37117525The B-type lamin is required for somatic repression of testis-specific gene clusters
Q47068972The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development
Q36350569The Dynamics and Regulatory Mechanism of Pronuclear H3k9me2 Asymmetry in Mouse Zygotes
Q92715615The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia
Q24558692The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor
Q37631226The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals
Q57295438The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
Q24317426The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin
Q34618586The Immediate Early Gene Product EGR1 and Polycomb Group Proteins Interact in Epigenetic Programming during Chondrogenesis
Q24672128The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression
Q42519231The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin
Q37546071The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis
Q28512405The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration
Q33247592The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase
Q92205124The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons
Q39801387The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene
Q36127086The Krüppel-associated box repressor domain can induce reversible heterochromatization of a mouse locus in vivo.
Q35089043The Krüppel-associated box repressor domain induces reversible and irreversible regulation of endogenous mouse genes by mediating different chromatin states
Q33631545The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling
Q37680327The PR-Set7 binding domain of Riz1 is required for the H4K20me1-H3K9me1 trans-tail 'histone code' and Riz1 tumor suppressor function
Q33933099The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster
Q47765950The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution
Q37937460The Roles of the Methyl-CpG Binding Proteins in Cancer
Q73513751The SCAN domain defines a large family of zinc finger transcription factors
Q24811144The SET-domain protein superfamily: protein lysine methyltransferases
Q37581605The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells
Q36141179The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28.
Q24595581The accessible chromatin landscape of the human genome
Q33546685The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues.
Q37832719The changing faces of HP1: From heterochromatin formation and gene silencing to euchromatic gene expression: HP1 acts as a positive regulator of transcription
Q28183858The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome
Q36408543The contradictory definitions of heterochromatin: transcription and silencing.
Q37958430The control of HIV transcription: keeping RNA polymerase II on track
Q90196318The control of gene expression and cell identity by H3K9 trimethylation
Q46263609The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Q92883018The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses
Q28068278The epigenome: the next substrate for engineering
Q33235274The evolution of the histone methyltransferase gene Su(var)3-9 in metazoans includes a fusion with and a re-fission from a functionally unrelated gene
Q38992195The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses.
Q34283901The genetic basis of non-syndromic intellectual disability: a review
Q36250669The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target
Q24336175The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells
Q92558804The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
Q52319773The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis
Q35113394The methyl-CpG binding domain and the evolving role of DNA methylation in animals
Q45062538The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.
Q36319982The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units
Q42813673The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response
Q35640798The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin
Q41462037The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components
Q24306374The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain
Q96222254The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
Q34531694The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
Q40149571The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus
Q41906267The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression
Q40215892The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation
Q38128684Towards an understanding of the regulatory mechanisms of totipotency
Q34179511Transcription and RNA interference in the formation of heterochromatin.
Q34181413Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma
Q42155239Transcription factor effector domains
Q33707631Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene
Q38043829Transcription-associated histone modifications and cryptic transcription
Q37512799Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells
Q37429465Transcriptional control of brown adipocyte development and physiological function--of mice and men.
Q34531622Transcriptional regulators TRIM28, SETDB1, and TP53 are aberrantly expressed in porcine embryos produced by in vitro fertilization in comparison to in vivo- and somatic-cell nuclear transfer-derived embryos
Q90484418Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast
Q28709521Transposable Elements Re-Wire and Fine-Tune the Transcriptome
Q57026544Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8
Q35199282Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines
Q41970615Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: regulation of lysine methyltransferases by physical interaction with their substrates.
Q36418751Tripartite Motif Containing 28 (Trim28) Can Regulate Cell Proliferation by Bridging HDAC1/E2F Interactions
Q47069021Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development
Q38736774URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells
Q52723071USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization
Q28109675Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity
Q40654465Unique DNA methylome profiles in CpG island methylator phenotype colon cancers
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Q53306403Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis.
Q33502742Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development
Q34476349Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small molecules
Q36663018X-linked mental retardation and epigenetics
Q98192782ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair
Q38871585ZFP57 and the Targeted Maintenance of Postfertilization Genomic Imprints.
Q41147495ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs
Q24318366ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes
Q35499791ZNF300 knockdown inhibits forced megakaryocytic differentiation by phorbol and erythrocytic differentiation by arabinofuranosyl cytidine in K562 cells
Q34398844ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation
Q53176450Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A.
Q42367973dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.
Q33336609dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster
Q28543055hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells
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Q89863683ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators

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