Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein.

scientific article published on 29 December 2010

Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein. is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.01647-10
P932PMC publication ID3067960
P698PubMed publication ID21191025

P50authorJosé HurstQ83058498
P2093author name stringThomas Iftner
Frank Stubenrauch
Elke Straub
Jasmin Fertey
Astrid Schenker
P2860cites workKAP-1, a novel corepressor for the highly conserved KRAB repression domainQ24317676
Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factorQ24336617
Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosisQ24532089
Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essentialQ24551928
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Krüppel-associated boxes are potent transcriptional repression domainsQ24563259
Brd4 links chromatin targeting to HPV transcriptional silencingQ24676251
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteinsQ24685694
Papillomaviruses and cancer: from basic studies to clinical applicationQ29614745
Human papillomavirus is a necessary cause of invasive cervical cancer worldwideQ29617514
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expressionQ33734803
Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell linesQ33782708
Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibitionQ33802567
NCoR1 mediates papillomavirus E8;E2C transcriptional repressionQ33826645
Human papillomavirus type 1 produces redundant as well as polycistronic mRNAs in plantar wartsQ33905805
Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylationQ33951238
E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell deathQ34647460
Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathwaysQ34676199
RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cellsQ34977316
Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathwaysQ35815917
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Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cellsQ38299944
Inhibition of transcription and DNA replication by the papillomavirus E8-E2C protein is mediated by interaction with corepressor moleculesQ38610600
The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytesQ39588185
The E8 domain confers a novel long-distance transcriptional repression activity on the E8E2C protein of high-risk human papillomavirus type 31.Q39602415
Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sitesQ40065520
The papillomavirus E8-E2C protein represses DNA replication from extrachromosomal originsQ40172142
Gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by HPV18 but no changes between keratinocytes with integrated or episomal viral genomesQ40260839
Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis.Q40379237
Papillomavirus E2 induces p53-independent apoptosis in HeLa cellsQ40932326
Detection of novel splicing patterns in a HPV16-containing keratinocyte cell lineQ41723300
Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression.Q41862182
The E8--E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytesQ41994813
Characterization of cDNAs of spliced HPV-11 E2 mRNA and other HPV mRNAs recovered via retrovirus-mediated gene transferQ42642255
Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus.Q42808686
Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein.Q44278348
HPV and cervical cancer in the 2007 report.Q51110968
The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.Q52537500
The E8 repression domain can replace the E2 transactivation domain for growth inhibition of HeLa cells by papillomavirus E2 proteins.Q53331971
Carcinogenicity of human papillomavirusesQ58296516
Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 geneQ71084079
Direct activation of caspase 8 by the proapoptotic E2 protein of HPV18 independent of adaptor proteinsQ81109530
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)2918-2926
P577publication date2010-12-29
P1433published inJournal of VirologyQ1251128
P1476titleGrowth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein
P478volume85