KAPtain in charge of multiple missions: Emerging roles of KAP1

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KAPtain in charge of multiple missions: Emerging roles of KAP1 is …
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P356DOI10.4331/WJBC.V5.I3.308
P3181OpenCitations bibliographic resource ID2414886
P932PMC publication ID4160525
P698PubMed publication ID25225599

P2093author name stringChun-Ting Cheng
P2860cites workGenome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFsQ21563454
TIF1gamma, a novel member of the transcriptional intermediary factor 1 familyQ22008759
KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.Q22010040
Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactionsQ22011176
A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1Q24290346
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1Q24290549
MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin LigasesQ24300816
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1Q24301603
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencingQ24303619
The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domainQ24306374
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1Q24307960
Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1Q24317298
KAP-1, a novel corepressor for the highly conserved KRAB repression domainQ24317676
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repairQ24323354
KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesionsQ24337449
Proviral Silencing in Embryonic Cells Is Regulated by Yin Yang 1Q42036532
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.Q42152404
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage responseQ42182193
The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective responseQ42813673
Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms.Q42830538
Kaposi's Sarcoma-Associated Herpesvirus Kaposin B Induces Unique Monophosphorylation of STAT3 at Serine 727 and MK2-Mediated Inactivation of the STAT3 Transcriptional Repressor TRIM28Q43079558
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewalQ43148740
KAP1 controls endogenous retroviruses in embryonic stem cellsQ43193929
Defective ATM‐Kap‐1‐mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse modelQ44040294
KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress.Q48309017
Trim28 is required for epigenetic stability during mouse oocyte to embryo transition.Q48652732
Clinical utility of KAP-1 expression in thyroid lesionsQ51018353
Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouseQ52120878
Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.Q52167677
TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.Q53282568
KAP1 is associated with peritoneal carcinomatosis in gastric cancerQ53361170
TRIM28 prevents autoinflammatory T cell development in vivoQ54312343
Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.Q54458965
KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expressionQ80994497
A reverse-ELISA for the detection of TRIM28/KAP1 serum autoantibodies in colorectal cancer patientsQ83304379
Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65Q84652888
KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophagesQ85006320
Regulation of E2F1 function by the nuclear corepressor KAP1Q24337687
Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1Q24338624
Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 familyQ24529929
Modification with SUMO. A role in transcriptional regulationQ24534589
Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essentialQ24551928
Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRDQ24602561
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2Q24647310
A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteinsQ24654804
The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repressionQ24672128
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activityQ24676311
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteinsQ24685694
KRAB-containing zinc-finger repressor proteinsQ24792646
KAP1 regulates gene networks controlling T-cell development and responsiveness.Q27319505
Factors determining DNA double-strand break repair pathway choice in G2 phaseQ28118755
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreadingQ28473103
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptorsQ28504688
Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machineryQ28512720
Embryonic stem cells use ZFP809 to silence retroviral DNAsQ28592550
Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28Q28771756
Linking DNA methylation and histone modification: patterns and paradigmsQ29617801
A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding proteinQ31988206
Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.Q33347938
Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressorsQ33748031
HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repairQ33862272
TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent mannerQ33934676
A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing.Q33972163
MAGE I Transcription Factors Regulate KAP1 and KRAB Domain Zinc Finger Transcription Factor Mediated Gene RepressionQ34005548
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivationQ34016183
Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction.Q34142405
Distinct localizations and repression activities of MM-1 isoforms toward c-Myc.Q34452325
KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interactionQ34575873
Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks.Q39325474
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatinQ39328119
The TRIM family protein KAP1 inhibits HIV-1 integration.Q39525383
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.Q39737989
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repairQ39750906
Epigenetic regulation of TLR4 gene expression in intestinal epithelial cells for the maintenance of intestinal homeostasisQ39784845
KAP1-independent transcriptional repression of SCAN-KRAB-containing zinc finger proteinsQ39810358
The impact of heterochromatin on DSB repairQ39851599
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.Q39859206
Physical and functional interactions between STAT3 and KAP1.Q40044888
MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell linesQ40066322
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repressionQ40066661
TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cellsQ40070550
Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation.Q40155065
Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domainQ40171341
Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cellsQ40213321
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathwayQ40252252
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatinQ34801409
ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombinationQ34917270
Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancerQ34977115
Functional analysis of KAP1 genomic recruitmentQ35096261
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.Q35144590
Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7Q35402128
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regionsQ35534127
A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.Q35632581
Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domainQ35694053
Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage ResponseQ36003622
Tripartite Motif Containing 28 (Trim28) Can Regulate Cell Proliferation by Bridging HDAC1/E2F InteractionsQ36418751
TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cellsQ36471255
Primer binding site-dependent restriction of murine leukemia virus requires HP1 binding by TRIM28.Q36540170
Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancerQ36751568
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagyQ36799136
TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cellsQ36841416
The KRAB-ZFP/KAP1 system contributes to the early embryonic establishment of site-specific DNA methylation patterns maintained during developmentQ36915286
A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy.Q36917344
Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1α (HP1α) with HeterochromatinQ36929141
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.Q36931943
Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.Q36972688
The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 PhosphorylationQ36972711
Disruption of the interaction between transcriptional intermediary factor 1{beta} and heterochromatin protein 1 leads to a switch from DNA hyper- to hypomethylation and H3K9 to H3K27 trimethylation on the MEST promoter correlating with gene reactivaQ37035161
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cellsQ37264809
Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinaseQ37317681
TRIM28 is essential for erythroblast differentiation in the mouseQ37349418
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiationQ37495466
Chromatin mechanisms in genomic imprintingQ37598629
KAP1 protein: an enigmatic master regulator of the genomeQ37886421
Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approachesQ38300835
Repression of the c-fms gene in fibroblast cells by c-Myc-MM-1-TIF1beta complexQ38337928
Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cellsQ39077366
Opposing roles for 53BP1 during homologous recombination.Q39106487
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cellsQ39108859
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)308-20
P577publication date2014-08-26
P13046publication type of scholarly workreview articleQ7318358
P1433published inWorld journal of biological chemistryQ27723536
P1476titleKAPtain in charge of multiple missions: Emerging roles of KAP1
P478volume5