Epigenetics of estrogen receptor-negative primary breast cancer

scientific article published on May 2012

Epigenetics of estrogen receptor-negative primary breast cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1586/ERM.12.26
P698PubMed publication ID22616702

P2093author name stringDave S B Hoon
Edward S Greenberg
Kelly K Chong
Kelly T Huynh
P2860cites workMicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancerQ21195215
Translating the Histone CodeQ22065840
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication fociQ22254582
The Polycomb group protein EZH2 directly controls DNA methylationQ24299020
An operational definition of epigeneticsQ24568002
miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNAQ24644154
MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancerQ24645663
CpG island methylator phenotype in colorectal cancerQ24672170
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsQ24672969
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinQ24682617
Epigenetic regulation in estrogen receptor positive breast cancer--role in treatment responseQ27694612
MicroRNA gene expression deregulation in human breast cancerQ27860690
Chromatin modifications and their functionQ27861067
Role of histone H3 lysine 27 methylation in Polycomb-group silencingQ28131795
Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cellsQ28256740
Cadherin switch in tumor progressionQ28262569
The epigenomics of cancerQ28289975
Epigenetics in cancerQ29547853
miR-21-mediated tumor growthQ29616149
Epigenetics in cancerQ29617139
Epigenetic modifications and human diseaseQ29619753
American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancerQ30494798
CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancerQ33235269
Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancerQ33362180
An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples.Q33533878
DNA methylome of familial breast cancer identifies distinct profiles defined by mutation statusQ33708624
Minimising immunohistochemical false negative ER classification using a complementary 23 gene expression signature of ER statusQ33769803
Estrogen receptor-alpha methylation predicts melanoma progressionQ33797076
Involvement of members of the cadherin superfamily in cancerQ33899441
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patternsQ34048118
Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experienceQ34187884
Development of sporadic microsatellite instability in colorectal tumors involves hypermethylation at methylated-in-tumor loci in adenomaQ34254446
Downregulation of miR-342 is associated with tamoxifen resistant breast tumors.Q34506613
Aberrant DNA methylation in malignant melanomaQ34516587
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosisQ34835189
MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory PathwaysQ34868281
A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancerQ35034708
Delineating an epigenetic continuum for initiation, transformation and progression to breast cancerQ35110475
Breast cancer methylomes establish an epigenomic foundation for metastasisQ35136051
Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progressionQ35636561
microPrimer: the biogenesis and function of microRNA.Q36285669
Array-based multiplex analysis of DNA methylation in breast cancer tissuesQ36329331
Correlation between CpG methylation profiles and hormone receptor status in breast cancersQ36393321
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell linesQ36465214
MicroRNA-cancer connection: the beginning of a new taleQ36555283
Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors.Q36787353
Epigenomics and breast cancerQ37078784
CpG island methylator phenotype predicts progression of malignant melanomaQ37245444
Epigenetic cross-talk between DNA methylation and histone modifications in human cancersQ37314994
Targeting DNA methylationQ37320354
Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatmentQ37324446
ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancersQ37407136
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cellsQ37515409
The epigenetics of breast cancerQ37772356
Molecularly targeted endocrine therapies for breast cancer.Q37815616
Cancer epigenetics reaches mainstream oncologyQ37851012
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia.Q38422359
Simultaneous analysis of the methylation profile of 26 cancer related regions in invasive breast carcinomas by MS-MLPA and drMS-MLPA.Q39690990
ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitorQ40014619
The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines.Q40168734
Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylationQ40195308
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexesQ40266897
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancerQ40490715
Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome.Q42452150
Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines.Q44653608
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine.Q44657529
Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virusQ45419139
Quantification of LINE1 in circulating DNA as a molecular biomarker of breast cancer.Q45948475
Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer.Q51535040
Promoter CpG island hypermethylation during breast cancer progression.Q53449089
Estrogen receptors: role in breast cancer.Q53595317
CpG hypomethylation of MDR1 gene in tumor and serum of invasive ductal breast carcinoma patients.Q54456631
Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinomaQ57161281
P433issue4
P921main subjectepigeneticsQ26939
P304page(s)371-382
P577publication date2012-05-01
P1433published inExpert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcareQ15756305
P1476titleEpigenetics of estrogen receptor-negative primary breast cancer
P478volume12

Reverse relations

cites work (P2860)
Q35975638Estrogen Receptor Expression Is Associated with DNA Repair Capacity in Breast Cancer
Q33721430Estrogen induces Vav1 expression in human breast cancer cells
Q88139964How does genome sequencing impact surgery?
Q35184055Modern reproductive patterns associated with estrogen receptor positive but not negative breast cancer susceptibility
Q35963443Role of epigenetic modifications in luminal breast cancer