Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells

scientific article published on 21 May 2009

Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10549-009-0420-3
P932PMC publication ID3901992
P698PubMed publication ID19459041

P2093author name stringNancy E Davidson
Madhavi Billam
Michele D Sobolewski
P2860cites workEpigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?Q22251049
The genomic landscapes of human breast and colorectal cancersQ27861078
DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsQ28212826
The epigenomics of cancerQ28289975
Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines.Q32107346
Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activityQ34153545
Clonogenic assay of cells in vitro.Q34615431
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cellsQ35545116
Zebularine: a new drug for epigenetic therapyQ35928384
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biologyQ36296406
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosineQ37576837
Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatmentQ39438664
Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidineQ39471085
Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosidesQ39548154
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cellsQ39887368
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell linesQ40163040
Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression.Q40178236
Decitabine activates specific caspases downstream of p73 in myeloid leukemiaQ40367523
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cellsQ40424419
Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.Q40448993
Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.Q40458280
Preferential response of cancer cells to zebularine.Q40523300
Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genesQ40671720
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.Q41342928
Expression of estrogen receptors in estrogen receptor-negative human breast carcinoma cells: modulation of epidermal growth factor-receptor (EGF-R) and transforming growth factor alpha (TGF alpha) gene expressionQ41482030
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cellsQ41858565
Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminaseQ42221528
The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitorQ42272315
Oestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cellsQ42451074
Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cellsQ42825623
Inhibition of DNA methylation and reactivation of silenced genes by zebularineQ44346779
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine.Q44657529
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.Q44885739
Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cellsQ45299490
Synergistic action of 5-aza-2'-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cellsQ45540656
Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone 1 1Edited by J. KarnQ58212769
Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminaseQ67535912
Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminaseQ71271741
Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrestQ73086545
Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibitionQ73393598
Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer modelsQ79453002
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P304page(s)581-592
P577publication date2009-05-21
P1433published inBreast Cancer Research and TreatmentQ326085
P1476titleEffects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells
P478volume120

Reverse relations

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