Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience

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Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CNCR.22508
P932PMC publication ID2952542
P698PubMed publication ID17315156
P5875ResearchGate publication ID6491082

P50authorFarhad RavandiQ40614280
Jean-Pierre J IssaQ55459879
Jorge Eduardo CortesQ60320900
Hagop KantarjianQ60394812
Susan O'BrienQ66370727
Guillermo Garcia-ManeroQ66385413
Xuelin HuangQ87045391
Carlos B Bueso-RamosQ90223571
Jianqin ShanQ114427924
Jan DavissonQ114427941
P2860cites workProposals for the classification of the myelodysplastic syndromesQ28275931
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized studyQ28301602
International scoring system for evaluating prognosis in myelodysplastic syndromesQ28305247
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.Q34128471
A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcomeQ34308142
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemiaQ34553286
Novel therapies for myelodysplastic syndromesQ35829958
Bayesian clinical trialsQ36399554
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid LeukemiaQ40543180
Report of an international working group to standardize response criteria for myelodysplastic syndromes.Q40737646
Bone marrow transplantation from HLA-identical siblings as treatment for myelodysplasiaQ44548405
World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.Q46038765
Long-term follow-up results of the combination of topotecan and cytarabine and other intensive chemotherapy regimens in myelodysplastic syndromeQ46910751
Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)Q47924458
Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasiaQ58865927
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
myelodysplastic syndromeQ954625
chemotherapyQ974135
P304page(s)1133-1137
P577publication date2007-03-01
P1433published inCancerQ326041
P1476titleSurvival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience
P478volume109

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cites work (P2860)
Q376017785-azacitidine prolongs overall survival in patients with myelodysplastic syndrome--a systematic review and meta-analysis
Q33769335A phase 1-2 study of a farnesyltransferase inhibitor, tipifarnib, combined with idarubicin and cytarabine for patients with newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndrome
Q33939624A phase I dose escalation study of oral bexarotene in combination with intravenous decitabine in patients with AML.
Q40228044A preliminary study on the outcome of lower-risk myelodysplastic syndrome by low-dose decitabine
Q24622700An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes
Q85213650Arsenic trioxide and low-dose cytarabine for patients with intermediate-2 and high-risk myelodysplastic syndrome
Q37277994Changing the treatment paradigm in myelodysplastic syndromes
Q34686726Clofarabine: past, present, and future
Q37973280Combination strategies in myelodysplastic syndromes.
Q46060620CpG island methylation patterns in chronic lymphocytic leukemia
Q58110507Current Management and Recent Advances in the Treatment of Chronic Myelomonocytic Leukemia
Q37771015Current and future management options for myelodysplastic syndromes
Q48587178Cytogenetic abnormalities in a series of 1,029 patients with primary myelodysplastic syndromes: a report from the US with a focus on some undefined single chromosomal abnormalities
Q38979940DNA Hypomethylating Drugs in Cancer Therapy
Q38233492Deacetylase inhibitors for the treatment of myelodysplastic syndromes
Q36911488Decitabine and its role in the treatment of hematopoietic malignancies
Q37493954Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors
Q34088403Decitabine in the treatment of myelodysplastic syndromes.
Q37742267Decitabine priming prior to low-dose chemotherapy improves patient outcomes in myelodysplastic syndromes-RAEB: a retrospective analysis vs. chemotherapy alone
Q34847863Demethylating agents in myeloid malignancies
Q35039868Derivation and validation of the SEER-Medicare myelodysplastic syndromes risk score (SMMRS).
Q46047561Durable clinical and cytogenetic remission in an elderly patient with relapsed acute myeloid leukemia treated with low-dose lenalidomide
Q36001930Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies
Q38185555Epigenetic alterations in osteosarcoma: promising targets
Q27694612Epigenetic regulation in estrogen receptor positive breast cancer--role in treatment response
Q37850456Epigenetic regulation in myelodysplastic syndromes: implications for therapy
Q37184917Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias
Q37964702Epigenetic-based therapies in cancer: progress to date
Q38012175Epigenetics of estrogen receptor-negative primary breast cancer
Q35183982Evaluation of noncytotoxic DNMT1-depleting therapy in patients with myelodysplastic syndromes.
Q34768789Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies
Q28283836Feasibility of therapy with hypomethylating agents in patients with renal insufficiency
Q90734746Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high-risk MDS: Phase 2 study results
Q35202854How much? How frequent? How long? A clinical guide to new therapies in myelodysplastic syndromes
Q34667051Hypomethylating agents and other novel strategies in myelodysplastic syndromes
Q36545064Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Q80855046Impact of remission induction chemotherapy on survival in older adults with acute myeloid leukemia
Q58706592Incidence and risk of hematologic toxicities with hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukopenia: A systematic review and meta-analysis
Q36055095Maintenance Therapy with Decitabine after Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome
Q37108489Management of myelodysplastic syndromes: 2008 update.
Q39172636Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes.
Q55021852MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.
Q36203084Model-based adaptive phase I trial design of post-transplant decitabine maintenance in myelodysplastic syndrome
Q26801573Molecular Testing in Myelodysplastic Syndromes for the Practicing Oncologist: Will the Progress Fulfill the Promise?
Q26749870Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy
Q87476851Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes
Q24323093Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine
Q55969986Myelodysplastic syndromes: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Q98471223New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP
Q54979651Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report.
Q42124715Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy
Q37866296Pharmacokinetic evaluation of decitabine for the treatment of leukemia
Q38470137Pilot study on combination of azacitidine and low-dose cytarabine for patients with refractory anemia with excess blast
Q36140902Platelet response during the second cycle of decitabine treatment predicts response and survival for myelodysplastic syndrome patients
Q33380307Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System
Q34749123RUNX3 gene promoter demethylation by 5-Aza-CdR induces apoptosis in breast cancer MCF-7 cell line
Q37382559Recent progress and clinical importance on pharmacogenetics in cancer therapy.
Q39527812Response to pretransplant hypomethylating agents influences the outcome of allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndromes
Q35058556Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia
Q33995598Retrospective analysis of prognostic factors associated with response and overall survival by baseline marrow blast percentage in patients with myelodysplastic syndromes treated with decitabine
Q33392293Subcutaneous or intravenous administration of romiplostim in thrombocytopenic patients with lower risk myelodysplastic syndromes
Q37320354Targeting DNA methylation
Q36138278The challenge of individualised risk assessment and therapy planning in elderly high-risk myelodysplastic syndromes (MDS) patients
Q40092610The efficacy and safety of the patients of myelodysplastic syndromes-refractory anemia with excess blasts treated with decitabine alone or CAG/HAG regimen
Q37404489The evolution of hematopoietic SCT in myelodysplastic syndrome
Q36280941The impact of hypomethylating agents on the cost of care and survival of elderly patients with myelodysplastic syndromes
Q36833557The myelodysplastic syndrome as a prototypical epigenetic disease
Q36612553The revolution of myelodysplastic syndromes
Q37271941Therapeutic advances in leukemia and myelodysplastic syndrome over the past 40 years
Q38235662Update on the pharmacotherapy for myelodysplastic syndromes.
Q64059660mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy
Q43249171p53 and DNA methylation suppress the TRAIN to cell death
Q36848202p53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignancies

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