Quality control for unfolded proteins at the plasma membrane

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Quality control for unfolded proteins at the plasma membrane is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.201006012
P932PMC publication ID3003321
P698PubMed publication ID20974815
P5875ResearchGate publication ID47544254

P50authorPirjo M ApajaQ57051463
Gergely L LukacsQ38322272
P2093author name stringHaijin Xu
P2860cites workThe co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteinsQ24290709
c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2Q24294848
Folding efficiency is rate-limiting in dopamine D4 receptor biogenesisQ24297696
VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargoQ24299091
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4Q24299260
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activityQ24302505
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chainsQ24306305
Protein quality control: U-box-containing E3 ubiquitin ligases join the foldQ44061660
Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugatesQ47198618
Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease.Q50335672
Structure and interactions of the helical and U-box domains of CHIP, the C terminus of HSP70 interacting protein.Q51586726
Vasopressin V2 receptor mutants that cause X-linked nephrogenic diabetes insipidus: analysis of expression, processing, and function.Q54580161
Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during BiosynthesisQ56648628
EndocytosisQ57374715
Quality control of a mutant plasma membrane ATPase: ubiquitylation prevents cell-surface stabilityQ57375268
The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coliQ69496214
The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 associationQ73171130
The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificitiesQ81594841
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptorQ24320318
Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defectsQ24642920
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradationQ24643067
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomesQ24676764
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodiesQ27651780
Mechanisms underlying ubiquitinationQ27860656
A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodiesQ27931399
ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sortingQ27931999
Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1Q27932129
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.Q27939053
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.Q27939550
Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutantsQ28115855
ESCRT-III dysfunction causes autophagosome accumulation and neurodegenerationQ28117494
Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90Q28143497
Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalphaQ28144122
Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidusQ28183211
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestinQ28190513
ErbB2 degradation mediated by the co-chaperone protein CHIPQ28208008
Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidusQ28208115
Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum.Q28573360
Derlin-dependent accumulation of integral membrane proteins at cell surfacesQ28588156
Ubiquitin-binding domains - from structures to functionsQ29614829
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradationQ29616141
Biological and chemical approaches to diseases of proteostasis deficiencyQ29616633
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteinsQ29617399
Pathways of chaperone-mediated protein folding in the cytosolQ29618887
Quality control in the endoplasmic reticulumQ29619929
Chaperone functions of the E3 ubiquitin ligase CHIP.Q30362083
Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cellsQ30439237
Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.Q31742906
Inefficient quality control of thermosensitive proteins on the plasma membraneQ33425200
Ubiquitin-mediated targeting of a mutant plasma membrane ATPase, Pma1-7, to the endosomal/vacuolar system in yeastQ33693280
Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality controlQ33761462
ER protein quality control and proteasome-mediated protein degradationQ33794243
Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domainQ33912615
A mutant plasma membrane ATPase, Pma1-10, is defective in stability at the yeast cell surfaceQ33929848
Yeast mutants affecting possible quality control of plasma membrane proteinsQ33957947
Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIPQ34048681
Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseasesQ34142252
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/NeuQ34190181
ER quality control: towards an understanding at the molecular levelQ34309048
A new ticket for entry into budding vesicles-ubiquitinQ34365247
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidusQ34584278
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.Q34617875
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicatorQ34650064
Recognition of a single transmembrane degron by sequential quality control checkpointsQ34814483
Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systemsQ34970141
ER-associated degradation in protein quality control and cellular regulationQ34970862
Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attentionQ35693428
CHIP: a link between the chaperone and proteasome systemsQ35759085
High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexesQ35822226
Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitinationQ35942358
Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machineryQ36017039
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative diseaseQ36119653
Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosisQ36176561
Retrograde transport of Golgi-localized proteins to the ER.Q36254921
Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targetingQ36255053
COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartmentsQ36326371
Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transferQ36345018
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradationQ36359536
Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathwayQ36846031
Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomesQ36906047
N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane trafficQ37234365
Arrestins as adaptors for ubiquitination in endocytosis and sortingQ37341630
The ubiquitylation machinery of the endoplasmic reticulumQ37424805
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligaseQ37453413
Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11).Q39933453
Analysis of endocytic trafficking by single-cell fluorescence ratio imagingQ39935449
Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cellsQ39936620
Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseasesQ40080714
Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcuminQ40180822
Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cellsQ40312393
Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein.Q40312400
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.Q40340333
Characterization of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus in a polarized cell modelQ40399721
Real-time monitoring of ubiquitination in living cells by BRET.Q40443828
Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis.Q40464949
A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump.Q40607981
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitinationQ40636866
The role of a conserved inter-transmembrane domain interface in regulating alpha(2a)-adrenergic receptor conformational stability and cell-surface turnoverQ40819594
Peripheral protein quality control removes unfolded CFTR from the plasma membraneQ41111670
The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stressQ41705356
Empty MHC class I molecules come out in the coldQ41725383
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded proteinQ41776375
Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains.Q41825273
Arrestin-mediated endocytosis of yeast plasma membrane transportersQ42931930
Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I moleculesQ43077741
Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.Q43240938
Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosisQ43610822
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectquality controlQ827792
P1104number of pages18
P304page(s)553-570
P577publication date2010-10-25
P1433published inJournal of Cell BiologyQ1524550
P1476titleQuality control for unfolded proteins at the plasma membrane
P478volume191