The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli

scientific article published on 01 May 1989

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0021-9258(18)83275-6
P698PubMed publication ID2651442

P2093author name stringR T Sauer
Sauer RT
Parsell DA
D A Parsell
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
proteolysisQ33123
P304page(s)7590-7595
P577publication date1989-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli
P478volume264

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cites work (P2860)
Q33307001A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm
Q30400559A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity
Q36560876A natural polymorphism in beta-lactamase is a global suppressor
Q36237652A pathway for targeting soluble misfolded proteins to the yeast vacuole
Q30425966A procedure for the prediction of temperature-sensitive mutants of a globular protein based solely on the amino acid sequence
Q42847774A single disulfide bond restores thermodynamic and proteolytic stability to an extensively mutated protein
Q34741989A single mutation responsible for temperature-sensitive entry and assembly defects in the VP1-2 protein of herpes simplex virus.
Q37593060Active barnase variants with completely random hydrophobic cores
Q38534181Aerobic inactivation of Rhizobium meliloti NifA in Escherichia coli is mediated by lon and two newly identified genes, snoB and snoC.
Q99560440Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria
Q90761948Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering
Q42737392Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae
Q92668161Binding of the von Willebrand Factor A Domain of Capillary Morphogenesis Protein 2 to Anthrax Protective Antigen Vaccine Reduces Immunogenicity in Mice
Q53725826Bulky Dehydroamino Acids Enhance Proteolytic Stability and Folding in β-Hairpin Peptides.
Q92994631Changes in gene expression predictably shift and switch genetic interactions
Q39929605Characterization of cytR mutations that influence oligomerization of mutant repressor subunits
Q36089743Chromophore transformations in red fluorescent proteins
Q42108085Comparing substrate specificity between cytochrome c maturation and cytochrome c heme lyase systems for cytochrome c biogenesis
Q35302671Computational design and selections for an engineered, thermostable terpene synthase
Q41594896Conjugation Strategy Strongly Impacts the Conformational Stability of a PEG-Protein Conjugate.
Q60960512Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases
Q33815221Core-binding factor influences the disease specificity of Moloney murine leukemia virus
Q51191562Correlation between antigenicity and variability in the vls antigenic variation system of Borrelia burgdorferi.
Q42920238Creation of a zymogen
Q30194443Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition
Q41836712Cytosolic selection systems to study protein stability.
Q34423146Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution
Q98181857Design of an engineered ACE2 as a novel therapeutics against COVID-19
Q24803075Directed evolution of single-chain Fv for cytoplasmic expression using the beta-galactosidase complementation assay results in proteins highly susceptible to protease degradation and aggregation
Q47253797Directed evolution to improve protein folding in vivo
Q34408072Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life
Q90182025Dynamics Rationalize Proteolytic Susceptibility of the Major Birch Pollen Allergen Bet v 1
Q44945553Effect of specific mutations in helix alpha7 of domain I on the stability and crystallization of Cry3A in Bacillus thuringiensis
Q40135575Energetics-based protein profiling on a proteomic scale: identification of proteins resistant to proteolysis
Q32884587Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane.
Q42008235Engineering a thermo-stable superoxide dismutase functional at sub-zero to >50°C, which also tolerates autoclaving
Q33762335Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.
Q31141217Evolutionary Stabilization of the Gene-3-protein of Phage fd Reveals the Principles that Govern the Thermodynamic Stability of Two-domain Proteins
Q39116654Experimental and Computational Analysis of Protein Stabilization by Gly-to-d-Ala Substitution: A Convolution of Native State and Unfolded State Effects
Q30192970Extensive modifications for methionine enhancement in the beta-barrels do not alter the structural stability of the bean seed storage protein phaseolin
Q35095644Folded proteins occur frequently in libraries of random amino acid sequences
Q36954399Forced extraction of targeted components from complex macromolecular assemblies
Q35607758Heterologous expression and biochemical characterization of a highly active and stable chloroplastic CuZn-superoxide dismutase from Pisum sativum
Q38942496How PEGylation influences protein conformational stability.
Q42859303Identification of autodigestion target sites in Bacillus subtilis neutral proteinase
Q34344306Impact of translational error‐induced and error‐free misfolding on the rate of protein evolution
Q33425200Inefficient quality control of thermosensitive proteins on the plasma membrane
Q42030822Insights into the structure-function relationships of pneumococcal cell wall lysozymes, LytC and Cpl-1.
Q27677037Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis
Q36151116Isolation and characterization of mutations in the bacteriophage lambda terminase genes
Q28301743Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo
Q38735117Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis
Q42549863Lean forward: Genetic analysis of temperature-sensitive mutants unfolds the secrets of oligomeric protein complex assembly
Q24676764Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
Q27671609Mutagenesis of Zinc Ligand Residue Cys221 Reveals Plasticity in the IMP-1 Metallo- -Lactamase Active Site
Q36118166Mutagenesis of ribosomal protein S8 from Escherichia coli: defects in regulation of the spc operon
Q42881980Mutagenic dissection of the sequence determinants of protein folding, recognition, and machine function.
Q33892231Nonlinear protein degradation and the function of genetic circuits
Q38206516Open questions in origin of life: experimental studies on the origin of nucleic acids and proteins with specific and functional sequences by a chemical synthetic biology approach
Q41858624Optimizing protein stability in vivo
Q42023355P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences
Q27335510Phenotypes on demand via switchable target protein degradation in multicellular organisms.
Q39977321Pre-folding IkappaBalpha alters control of NF-kappaB signaling
Q40775415Prediction and analysis of structure, stability and unfolding of thermolysin-like proteases
Q41830011Probing protein stability and proteolytic resistance by loop scanning: a comprehensive mutational analysis
Q36777578Proteases and protein degradation inEscherichia coli
Q46109533Proteolytic response to the expression of an abnormal beta-galactosidase in Escherichia coli
Q34412404Quality control for unfolded proteins at the plasma membrane
Q37451027Quantitative determination of ribosome nascent chain stability
Q32038325Random mutagenesis of 1-aminocyclopropane-1-carboxylate synthase: a key enzyme in ethylene biosynthesis
Q36466309Rapid profiling of disease alleles using a tunable reporter of protein misfolding.
Q39419740Rational design and evaluation of mammalian ribonuclease cytotoxins
Q24799937Recognition of secretory proteins in Escherichia coli requires signals in addition to the signal sequence and slow folding
Q34493140Reconstructed Ancestral Enzymes Impose a Fitness Cost upon Modern Bacteria Despite Exhibiting Favourable Biochemical Properties.
Q32012271Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidime
Q30176980Sequence replacements in the central beta-turn of plastocyanin
Q35882435Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
Q36277595Structural analysis of wild-type and mutant yeast calmodulins by limited proteolysis and electrospray ionization mass spectrometry
Q36956243Structural basis and function of XRN2 binding by XTB domains
Q42180351Structural dynamics of the amyloid β-protein monomer folding nucleus
Q35680575Structural stability of Bacillus thuringiensis delta-endotoxin homolog-scanning mutants determined by susceptibility to proteases
Q42133558Structure and stability of the lamin A tail domain and HGPS mutant
Q35802665Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast
Q35604377Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
Q33860709TSpred: a web server for the rational design of temperature-sensitive mutants
Q35919753The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction
Q34205435The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase
Q36912522The conserved core of a human SIR2 homologue functions in yeast silencing
Q30168443The design of a hyperstable mutant of the Abp1p SH3 domain by sequence alignment analysis
Q46427709The stability of extracellular beta-glucosidase from Aspergillus niger is significantly enhanced by non-covalently attached polysaccharides
Q41951688Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.
Q92369865Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis

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