Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells

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Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...735519S
P356DOI10.1371/JOURNAL.PONE.0035519
P932PMC publication ID3335148
P698PubMed publication ID22539977
P5875ResearchGate publication ID224856292

P50authorKazumitsu UedaQ37378470
P2093author name stringTakafumi Ichikawa
Michinori Matsuo
Noriyuki Kioka
Takayuki Sogabe
Takuhito Sezaki
Lucia Tomiyama
Kohki Inada
Kumiyo Kakuda
Yohsuke Matsuno
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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradationQ24290777
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Epithelial-mesenchymal transition and its implications for fibrosisQ24302042
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The epithelial-mesenchymal transition: new insights in signaling, development, and diseaseQ24683758
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Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transductionQ28213388
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
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Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cellQ28303777
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The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cellsQ28476375
Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- miceQ28506558
Complex networks orchestrate epithelial-mesenchymal transitionsQ29547478
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Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surfaceQ30159671
Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissectionQ31041732
Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transitionQ33411645
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WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions.Q34537084
Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic interventionQ35615604
Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling.Q35688456
Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral toleranceQ36366774
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-betaQ37052635
Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticityQ37078617
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Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in menQ37328109
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Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphologyQ38482451
Discs large 5 is required for polarization of citron kinase in mitotic neural precursorsQ38627287
c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic ChangesQ38789483
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.Q39532727
Erythropoietin suppresses epithelial to mesenchymal transition and intercepts Smad signal transduction through a MEK-dependent mechanism in pig kidney (LLC-PK1) cell linesQ39732359
The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signalingQ40891329
v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexinQ42803166
Activation of c-Jun amino-terminal kinase is required for retinoic acid-induced neural differentiation of P19 embryonal carcinoma cellsQ43713500
The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction networkQ44546122
Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's diseaseQ45758087
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)e35519
P577publication date2012-04-23
P1433published inPLOS OneQ564954
P1476titleRole of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells
P478volume7

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cites work (P2860)
Q37689146A comprehensive analysis of the human placenta transcriptome
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Q38846831Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5.
Q24339424Dlg5 interacts with the TGF-β receptor and promotes its degradation
Q28589659Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis
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Q39012294Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation
Q38931960Methylation-mediated silencing of Dlg5 facilitates bladder cancer metastasis
Q60950467Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease

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