Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease (scientific article published on 19 May 2009)

Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case–control disease association studies☆☆This work was supported

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The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

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Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

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Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

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Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

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Functional variants of OCTN cation transporter genes are associated with Crohn disease

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Genetic variation in DLG5 is associated with inflammatory bowel disease

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

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Anti-interleukin-12 antibody for active Crohn's disease

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Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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Crohn's disease and the NOD2 gene: a role for paneth cells

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rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

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Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2

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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

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Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease

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Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.

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Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease

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European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis

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The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications

Q36477912

CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation

Q38321426

Degranulation of paneth cells via toll-like receptor 9.

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Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells

Q40363586

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

Q41917631

NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes

Q42526336

In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis

Q43004178

Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients

Q43998624

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

Q46504948

Crohn's disease is associated with a toll-like receptor-9 polymorphism

Q47243561

Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis

Q47318019

An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population

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Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts.

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Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study.

Q51928366

TLR9 activation is defective in common variable immune deficiency.

Q51985336

Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.

Q52970473

Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus.

Q53626011

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

Q54511436

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

toll-like receptor

Q408004

P304

page(s)

1723-1733

P577

publication date

2009-05-19

P1433

published in

The American Journal of Gastroenterology

Q7713501

P1476

title

Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease

P478

volume

104

Reverse relations

cites work (P2860)

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