Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity

scientific article published on 03 December 2008

Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E08-09-0898
P932PMC publication ID2633387
P698PubMed publication ID19056678

P2093author name stringYe-Guang Chen
Wei Zuo
P2860cites workSARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptorQ22008583
Early endosomal regulation of Smad-dependent signaling in endothelial cellsQ24292399
Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesisQ24294300
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-cateninQ24299047
Transforming growth factor beta activates Smad2 in the absence of receptor endocytosisQ40729010
PC12 cells have caveolae that contain TrkA. Caveolae-disrupting drugs inhibit nerve growth factor-induced, but not epidermal growth factor-induced, MAPK phosphorylationQ40855683
Mechanism of TGFbeta receptor inhibition by FKBP12Q41101968
Activation of mitogen-activated protein kinase by membrane-targeted Raf chimeras is independent of raft localizationQ43678675
The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signallingQ43936643
Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signalingQ44308848
Distinct endocytic pathways regulate TGF-β receptor signalling and turnoverQ44419411
Hyaluronan regulates transforming growth factor-beta1 receptor compartmentalizationQ44844860
Differentiation plasticity regulated by TGF-beta family proteins in development and diseaseQ46933819
Cellular heparan sulfate negatively modulates transforming growth factor-beta1 (TGF-beta1) responsiveness in epithelial cellsQ46955947
Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging.Q48916119
Mapping of Eps15 domains involved in its targeting to clathrin-coated pits.Q50336609
FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors.Q52521102
p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.Q53388493
MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migrationQ79220430
Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasionQ80171744
Potential role of statin use in idiopathic pulmonary fibrosisQ81146355
Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2Q81480914
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formationQ24302554
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent mannerQ24308947
PPM1A functions as a Smad phosphatase to terminate TGFbeta signalingQ24338559
Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunitQ24537162
Lipid rafts and signal transductionQ28131735
Controlling TGF-beta signalingQ28139621
Smad-dependent and Smad-independent pathways in TGF-beta family signallingQ28208250
Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signalingQ28286249
The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cellsQ28299564
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcAQ28508328
Complex networks orchestrate epithelial-mesenchymal transitionsQ29547478
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancerQ29616379
TGF-beta and epithelial-to-mesenchymal transitionsQ29616456
Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signalingQ30478289
Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transductionQ30681334
TGF-beta signaling: positive and negative effects on tumorigenesisQ31034737
Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolaeQ33718468
Lipid rafts: elusive or illusive?Q33973937
A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domainsQ34132337
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitorsQ34207135
Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathwayQ34282576
Non-Smad TGF-beta signalsQ34443708
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progressionQ34655105
Plasma membrane-associated proteins are clustered into islands attached to the cytoskeletonQ35193303
Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated proteinQ35950181
Genetic programs of epithelial cell plasticity directed by transforming growth factor-betaQ36232185
Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.Q36313734
TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2Q36324038
Statins and cancer preventionQ36337970
TGF-beta signaling: a tale of two responsesQ36923146
Dissecting lipid raft facilitated cell signaling pathways in cancerQ37047889
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-betaQ37052635
Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling.Q40468389
Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway.Q40649590
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmembrane raftQ424178
P304page(s)1020-1029
P577publication date2008-12-03
P1433published inMolecular Biology of the CellQ2338259
P1476titleSpecific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity
P478volume20

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cites work (P2860)
Q36932954A dynein motor attachment complex regulates TGFß/Smad3 signaling
Q53098448Amplification of FGFR1 gene and expression of FGFR1 protein is found in different histological types of lung carcinoma.
Q38096319Caveolin and TGF-β entanglements
Q40088771Cholesterol depletion in cell membranes of human airway epithelial cells suppresses MUC5AC gene expression
Q39783884Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments
Q39329559Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.
Q50324524Depletion of membrane cholesterol compromised caspase-8 imparts in autophagy induction and inhibition of cell migration in cancer cells
Q34395698Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling
Q38829337Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells
Q34363558Disabled-2 downregulation promotes epithelial-to-mesenchymal transition
Q34022613Dynamics of TGF-β/Smad signaling
Q34305855FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms
Q37405583Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis
Q39262943Ganglioside GM3 participates in the TGF-β1-induced epithelial-mesenchymal transition of human lens epithelial cells
Q93241651Hypoxia induced δ-Catenin to enhance mice hepatocellular carcinoma progression via Wnt signaling
Q37397518Informatics approaches to understanding TGFbeta pathway regulation.
Q35686092Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes
Q35053912Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells
Q38827777Lipid rafts in immune signalling: current progress and future perspective.
Q33993093Lipid rafts play an important role for maintenance of embryonic stem cell self-renewal
Q36610011Lysophosphatidic acid promotes cell migration through STIM1- and Orai1-mediated Ca2+(i) mobilization and NFAT2 activation.
Q49919334Mechanistic insight into contextual TGF-β signaling.
Q28481657Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cells
Q47132894New Insights into the Mechanism of Action of Soluble Klotho
Q39013667Non-Smad Signaling Pathways of the TGF-β Family
Q38780491Nuclear receptor TLX inhibits TGF-β signaling in glioblastoma
Q39709591PAI-1 mediates the TGF-beta1+EGF-induced "scatter" response in transformed human keratinocytes
Q36294546PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor
Q28594751Palmitoylation regulates epidermal homeostasis and hair follicle differentiation
Q30537666Pancreatic cancer circulating tumour cells express a cell motility gene signature that predicts survival after surgery
Q38012228Post-translational regulation of TGF-β receptor and Smad signaling.
Q38957062Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling
Q36052551Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps
Q26996826Regulation of TGF-β Signal Transduction
Q35905598Regulation of TGF-β receptor activity
Q34249350Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells
Q41461912SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors
Q35872442ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation
Q30490342Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization
Q91863051Sleeping beauty genetic screen identifies miR-23b::BTBD7 gene interaction as crucial for colorectal cancer metastasis
Q37832528Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.
Q91943837Specificity, versatility, and control of TGF-β family signaling
Q63976716Statins affect human glioblastoma and other cancers through TGF-β inhibition
Q90631766TGF-β Signaling
Q38906099TGF-β Signaling from Receptors to Smads
Q90112387TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling
Q38920438TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism.
Q60923334Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery
Q39689422Tetraspanin CD151 regulates transforming growth factor beta signaling: implication in tumor metastasis.
Q64062269The Activin Receptor, Activin-Like Kinase 4, Mediates Activation of Hypoxia Inducible Factor-1
Q36122285The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.
Q37040558The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells
Q38070343The role of endocytic pathways in TGF-β signaling

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