Differentiation plasticity regulated by TGF-beta family proteins in development and disease

scientific article published in September 2007

Differentiation plasticity regulated by TGF-beta family proteins in development and disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NCB434
P698PubMed publication ID17762890
P5875ResearchGate publication ID6077284

P50authorRosemary J AkhurstQ91233041
P2093author name stringRik Derynck
P2860cites workMyostatin mutation associated with gross muscle hypertrophy in a childQ24297666
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressivaQ24321505
Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determinationQ24534967
Myostatin negatively regulates satellite cell activation and self-renewalQ24675245
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisQ28131703
Smad transcription factorsQ28284775
Bone morphogenetic proteinsQ28300236
Transforming growth factor-beta regulation of immune responsesQ28303115
Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defectsQ28506220
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryoQ28512702
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Evidence that fibroblasts derive from epithelium during tissue fibrosisQ29616581
High interstitial fluid pressure - an obstacle in cancer therapyQ29619719
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrixQ29619797
Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation.Q30480194
The role of Smad signaling in hematopoiesisQ33222328
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.Q33606662
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transitionQ33734595
Muscle regeneration in the prolonged absence of myostatinQ33830785
Non-Smad TGF-beta signalsQ34443708
Myostatin: biology and clinical relevanceQ34547599
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cellsQ34578176
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.Q34603719
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signalingQ35033676
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosisQ35087744
Revisiting the role of retinoid signaling in skeletal developmentQ35211792
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.Q35641963
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosisQ35746891
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stromaQ35748940
Histopathology of cutaneous squamous cell carcinoma and its variantsQ35750666
BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesisQ35900138
Regulation of muscle mass by myostatinQ35912777
Spindle cell metaplasia in follicular adenoma of the thyroid gland: case report and review of the literature.Q35934001
Myostatin and its implications on animal breeding: a reviewQ36019955
Genetic programs of epithelial cell plasticity directed by transforming growth factor-betaQ36232185
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineageQ36235105
Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.Q36313734
Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytesQ36324476
Concise review: bone morphogenetic protein pleiotropism in neural stem cells and their derivatives--alternative pathways, convergent signalsQ36594573
Transforming growth factor-beta 3 is required for secondary palate fusionQ37373842
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathwaysQ40757186
Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteinsQ40827270
Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressivaQ41174010
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiationQ42160419
Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formationQ46377767
Adipose-derived adult stromal cells heal critical-size mouse calvarial defectsQ46567472
Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report.Q51578610
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.Q54297451
Inhibition of TGF-beta modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinomaQ81402283
P433issue9
P304page(s)1000-1004
P577publication date2007-09-01
P1433published inNature Cell BiologyQ1574111
P1476titleDifferentiation plasticity regulated by TGF-beta family proteins in development and disease
P478volume9

Reverse relations

cites work (P2860)
Q47824296A mutation update on the LDS associated genes TGFB2/3 and SMAD2/3.
Q33733916ASK-ing EMT not to spread cancer
Q47847040Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease
Q33568654Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation
Q92755581Activation of TGF-β Canonical and Noncanonical Signaling in Bovine Lactoferrin-Induced Osteogenic Activity of C3H10T1/2 Mesenchymal Stem Cells
Q92671088Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate
Q55260314An NFκB-dependent mechanism of tumor cell plasticity and lateral transmission of aggressive features.
Q34977307An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Q37273999An autocrine loop between TGF-β1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype
Q36545124An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC.
Q39044432Androgen receptor inducing bladder cancer progression by promoting an epithelial-mesenchymal transition
Q43276050Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice
Q47725453Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer
Q24339143C18 ORF1, a novel negative regulator of transforming growth factor-β signaling
Q33966545CLIC4 and Schnurri-2: a dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease
Q37885165Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations
Q39648681Carcinoembryonic antigen interacts with TGF-{beta} receptor and inhibits TGF-{beta} signaling in colorectal cancers.
Q92348371Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms
Q34284046Co-expression analysis of fetal weight-related genes in ovine skeletal muscle during mid and late fetal development stages
Q27693607Complexities of TGF-β targeted cancer therapy
Q42147850Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network
Q30496670Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules.
Q28543093Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT
Q27302374Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling
Q39481263Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis.
Q38626767Cytoskeletal signaling in TGFβ-induced epithelial-mesenchymal transition
Q46328407D-mannose induces regulatory T cells and suppresses immunopathology.
Q27851466DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
Q84847835De novo lung cancer diagnosed 32 months after liver transplantation: report of a case
Q37735806Decitabine reverses TGF-β1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis
Q36723199Dermal adipocytes and hair cycling: is spatial heterogeneity a characteristic feature of the dermal adipose tissue depot?
Q37998023Differential Regulation of TGF-β/Smad Signaling in Hepatic Stellate Cells between Acute and Chronic Liver Injuries
Q52617207Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.
Q39441340Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
Q34979224ERBB Receptor Activation Is Required for Profibrotic Responses to Transforming Growth Factor β
Q38930830EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling
Q38936472Effect of collagen vascular disease-associated interstitial lung disease on the outcomes of lung cancer surgery
Q38039303Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis
Q33798864Epithelial-mesenchymal transition in prostate cancer: an overview.
Q47394908Exploring molecular mechanism of bone-forming capacity of Eurycoma longifolia: Evidence of enhanced expression of bone-related biomarkers.
Q45866814Expression of vimentin and survivin in clear cell renal cell carcinoma and correlation with p53.
Q34029378Fibrodysplasia ossificans progressiva: a blueprint for metamorphosis
Q35813719Fibrodysplasia ossificans progressiva: a human genetic disorder of extraskeletal bone formation, or--how does one tissue become another?
Q45051195Fibronectin fibrils regulate TGF-β1-induced Epithelial-Mesenchymal Transition.
Q38725648Gene therapy strategies to improve strength and quality of flexor tendon healing
Q37398195Generation of mice with a conditional allele for transforming growth factor beta 1 gene
Q47121253Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling
Q90352370H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling
Q33916249High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells
Q80507318Human mesenchymal stem cell transformation is associated with a mesenchymal-epithelial transition
Q30436925Identification of progenitor cells that contribute to heterotopic skeletogenesis
Q90672348Immune Cell Induced Migration of Osteoprogenitor Cells Is Mediated by TGF-β Dependent Upregulation of NOX4 and Activation of Focal Adhesion Kinase
Q39382972Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.
Q36732552Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.
Q36552107Inherited human diseases of heterotopic bone formation
Q34790572Insights from a rare genetic disorder of extra-skeletal bone formation, fibrodysplasia ossificans progressiva (FOP)
Q36790379Integration of multiple signaling pathways determines differences in the osteogenic potential and tissue regeneration of neural crest-derived and mesoderm-derived calvarial bones
Q36483438Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration
Q92784010Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
Q34236843Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons
Q35039000Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination
Q26776349Krüppel-like factor 17, a novel tumor suppressor: its low expression is involved in cancer metastasis
Q38266863Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma
Q92860048LncRNA XIST enhanced TGF-β2 expression by targeting miR-141-3p to promote pancreatic cancer cells invasion
Q47426600Long non-coding RNA SNHG1 regulates NOB1 expression by sponging miR-326 and promotes tumorigenesis in osteosarcoma
Q37697174Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-β1/p38/HSP27 signaling in renal cell carcinoma
Q54298655MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells.
Q38732277Mathematical models of cell phenotype regulation and reprogramming: Make cancer cells sensitive again!
Q37364008Matrix Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation.
Q92366574Mechanism of epithelial‑mesenchymal transition inhibited by miR‑203 in non‑small cell lung cancer
Q38336989Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects
Q37143914Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration
Q26769611Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis: Allies or enemies?
Q58733981Metformin inhibits ovarian cancer growth and migration in vitro and in vivo by enhancing cisplatin cytotoxicity
Q64994489MiR-940 inhibits TGF-β-induced epithelial-mesenchymal transition and cell invasion by targeting Snail in non-small cell lung cancer.
Q36772647Microfluidic artificial "vessels" for dynamic mechanical stimulation of mesenchymal stem cells
Q51567189Molecular mechanisms of transforming growth factor-β signaling and disease: The 59th Fujihara International Seminar, 2010.
Q34365632Molecular pathways and targets in prostate cancer
Q33687048Mutant p53 gain-of-function in cancer
Q41143462Negative feedback loop between ZBTB7A and TGF-β in breast cancer
Q89809785Network and pathway-based analyses of genes associated with osteoporosis
Q38086746Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives
Q29620040Non-Smad pathways in TGF-beta signaling
Q37044600Noncanonical TGF-β signaling during mammary tumorigenesis
Q26799919Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases
Q57269883Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling
Q36629996Oestrogen signalling in white adipose progenitor cells inhibits differentiation into brown adipose and smooth muscle cells
Q30539142Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart
Q34687503Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761.
Q39924024PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production
Q39029043Pharmacological and immunological targeting of tumor mesenchymalization
Q35384921Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin
Q38764247Plasticity underlies tumor progression: role of Nodal signaling
Q99579045Polydatin prevents bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β/Smad/ERK signaling pathway
Q50173304Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor.
Q42705478Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways.
Q21091051Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in TallyHo/JngJ mice
Q34140633Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex
Q58770630Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence
Q37437251Regulation of TGF-beta signaling by Smad7.
Q40534248Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells
Q33898042Requirement of a dynein light chain in TGFbeta/Smad3 signaling
Q37003924Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome
Q37591417Role of TGF-β in breast cancer bone metastases.
Q28081170Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)
Q36208494Role of altered signal transduction in heterotopic ossification and fibrodysplasia ossificans progressiva
Q33694557Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells
Q36521628Role of stem/progenitor cells in reparative disorders
Q37339711Roles of TGFbeta in metastasis
Q34542397SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition
Q33684614Signaling via Alk5 controls the ontogeny of lung Clara cells.
Q35649316Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells
Q42507999Smad2 decelerates re-epithelialization during gingival wound healing
Q53391030Smad3 and its phosphoisoforms are prognostic predictors of hepatocellular carcinoma after curative hepatectomy.
Q43492573Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6.
Q35868376Smad7 Modulates Epidermal Growth Factor Receptor Turnover through Sequestration of c-Cbl
Q34503198Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation
Q37078617Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity
Q58991601Studies on thePinctada fucataBMP-2 Gene: Structural Similarity and Functional Conservation of Its Osteogenic Potential within the Animal Kingdom
Q42724556TGF-β Conveys Undesirable Side Effects of Androgen Depletion
Q38747679TGF-β Effects on Prostate Cancer Cell Migration and Invasion Require FosB.
Q39155183TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Q39155158TGF-β Family Signaling in Tumor Suppression and Cancer Progression.
Q26995720TGF-β and BMP signaling in osteoblast differentiation and bone formation
Q28274611TGF-β family signaling in stem cells
Q37900199TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases
Q38633657TGF-β induces growth suppression in multiple myeloma MM.1S cells via E2F1.
Q36297071TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.
Q42059520TGF-β1 alters microRNA profile in human gastric cancer cells
Q57138555TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy
Q35608186TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow-derived proangiogenic cell differentiation, function, and neovascularization
Q47915386TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells
Q51065073TGF-β1-induced synthesis of collagen fibers in skeletal muscle-derived stem cells.
Q28288866TGFbeta in Cancer
Q28083107TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
Q28275410TGFβ signalling in context
Q33827621TGFβ1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors
Q51172851TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.
Q57142667Targeting TGF-beta in prostate cancer: therapeutic possibilities during tumor progression
Q39155151Targeting TGF-β Signaling for Therapeutic Gain
Q27012443Targeting TGF-β signaling in cancer
Q35583991Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy
Q36462348Targeting the TGFβ signalling pathway in disease
Q27021750Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy
Q33517772Targeting the transforming growth factor-beta signaling pathway in human cancer
Q38168211Tgf-Beta family signaling in embryonic stem cells.
Q36985643The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis
Q34020080The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling
Q28596581The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα
Q39076794The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance.
Q39140421The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.
Q44159142The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT.
Q50082534The concomitant apoptosis and EMT underlie the fundamental functions of TGF-β.
Q37403100The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization
Q64044987The fibrogenic chemokine CCL18 is associated with disease severity in Erdheim-Chester disease
Q38647611The footprint of TGF-β in airway remodeling of the mustard lung
Q36149873The importance of foetal movement for co-ordinated cartilage and bone development in utero : clinical consequences and potential for therapy.
Q26772167The pituitary TGFβ1 system as a novel target for the treatment of resistant prolactinomas
Q38129383The role of TGF-β in bone metastasis: novel therapeutic perspectives
Q33514874The transcriptional cofactor nab2 is induced by tgf-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma
Q36799312The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner
Q49693689Three-Dimensional Hepatocellular Carcinoma/Fibroblast Model on a Nanofibrous Membrane Mimics Tumor Cell Phenotypic Changes and Anticancer Drug Resistance.
Q28505676Transforming growth factor Beta2 is required for valve remodeling during heart development
Q35895390Transforming growth factor beta signaling in adult cardiovascular diseases and repair.
Q39963310Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity
Q37616967Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer
Q33926168Transgenic models for cytokine-induced neurological disease
Q33661529Two faces of TGF-beta1 in breast cancer
Q35810608Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression
Q38095920Vascular smooth muscle cell differentiation-2010.
Q37325944Video-assisted thoracoscopic surgery after renal transplantation: A single-institution experience
Q35539813Wild type N-ras displays anti-malignant properties, in part by downregulating decorin
Q34439684Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity
Q37684204miR-484 suppresses proliferation and epithelial-mesenchymal transition by targeting ZEB1 and SMAD2 in cervical cancer cells

Search more.