Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling

scientific article published on 10 October 2017

Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.21765
P932PMC publication ID5706882
P698PubMed publication ID29212236

P2093author name stringRita Nahta
Lily Yang
Robert C Castellino
Siobhan M Eze
Bridgette F Peake
P2860cites workMIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamilyQ24317134
Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathwayQ24620497
GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational ProspectiveQ26798142
Recent discoveries concerning the tumor - mesenchymal stem cell interactionsQ28074616
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cellsQ28275069
Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serumQ30452357
An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cellsQ33648678
Screening therapeutic EMT blocking agents in a three-dimensional microenvironmentQ33689694
Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cellsQ33698448
Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancerQ34099900
P38 MAPK contributes to resistance and invasiveness of HER2- overexpressing breast cancerQ34675545
Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1.Q34946846
Resistance to HER2-targeted therapies: a potential role for FOXM1.Q34955355
Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasionQ35087191
Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cellsQ35316842
FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cellsQ35741551
The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancerQ36592451
GDF15 promotes EMT and metastasis in colorectal cancerQ36729546
GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathwayQ37702121
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.Q38605925
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primatesQ38605928
A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics.Q38720963
KCNN4 channels participate in the EMT induced by PRL-3 in colorectal cancerQ39168782
EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytesQ39258711
GDF-15 contributes to proliferation and immune escape of malignant gliomasQ39695192
Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cellsQ39733775
The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cellsQ42473555
Differentiation plasticity regulated by TGF-beta family proteins in development and diseaseQ46933819
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligandQ47897710
GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.Q54623768
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinomaQ73653083
Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosisQ83563327
Growth differentiation factor-15 as a prognostic biomarker in ovarian cancerQ84472567
P433issue55
P407language of work or nameEnglishQ1860
P304page(s)94393-94406
P577publication date2017-10-10
P1433published inOncotargetQ1573155
P1476titleGrowth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling
P478volume8

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cites work (P2860)
Q55495948EZH2-Mediated Epigenetic Suppression of GDF15 Predicts a Poor Prognosis and Regulates Cell Proliferation in Non-Small-Cell Lung Cancer.
Q92036930Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts
Q92237192IGF1R facilitates epithelial-mesenchymal transition and cancer stem cell properties in neuroblastoma via the STAT3/AKT axis
Q60920838Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15)
Q92838091Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
Q60620984Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
Q54977309Targeting Forkhead Box M1 Transcription Factor in Breast Cancer.
Q92156666Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer
Q58718106hsa_circ_0061140 Knockdown Reverses FOXM1-Mediated Cell Growth and Metastasis in Ovarian Cancer through miR-370 Sponge Activity

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