MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

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MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily is …
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scholarly articleQ13442814

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P819ADS bibcode1997PNAS...9411514B
P356DOI10.1073/PNAS.94.21.11514
P3181OpenCitations bibliographic resource ID684033
P932PMC publication ID23523
P698PubMed publication ID9326641
P5875ResearchGate publication ID13899207

P50authorStella M. ValenzuelaQ40250107
Bradley J. WalshQ55727469
Walter D FairlieQ57417975
Kimberley J. PryorQ70823146
P2093author name stringX Y He
H P Zhang
M Bansal
R C Nicholson
A G Moore
S B Por
S N Breit
J M Robbins
A R Bauskin
M R Bootcov
S Mahler
M Donnellan
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P433issue21
P407language of work or nameEnglishQ1860
P921main subjectGrowth differentiation factor 15Q74581
macrophageQ184204
cell-cell signalingQ14758911
P304page(s)11514-11519
P577publication date1997-10-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily
P478volume94

Reverse relations

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Q37117179Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer
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Q47121253Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling
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Q37420336Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy
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Q37369895Macrophage inhibitory cytokine-1: a new player in melanoma development
Q35051499Macrophage inhibitory factor 1 acts as a potential biomarker in patients with esophageal squamous cell carcinoma and is a target for antibody-based therapy
Q34793000Maternal Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location
Q92509452Mechanically-induced GDF15 Secretion by Periodontal Ligament Fibroblasts Regulates Osteogenic Transcription
Q41197754Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
Q93192737Metabolic remodeling induced by mitokines in heart failure
Q38351948Microarray analysis uncovers retinoid targets in human bronchial epithelial cells
Q34700334Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
Q36440214Molecular Mechanisms of Trastuzumab-Based Treatment in HER2-Overexpressing Breast Cancer
Q36499656Molecular characterisation of canine nonsteroidal anti-inflammatory drug-activated gene (NAG-1).
Q42507061Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3.
Q91410942Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
Q28192995Molecular targets of dietary polyphenols with anti-inflammatory properties
Q38956732Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia
Q54917685Moonlighting Activity of Secreted Inflammation-Regulatory Proteins.
Q38616107Moonlighting proteins in cancer.
Q35821663Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.
Q48165741Multibiomarker analysis in patients with acute myocardial infarction
Q38679160Multiple TGF-β superfamily signals modulate the adult Drosophila immune response
Q89567501Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress
Q36739054Mutant GDF15 presents a poor prognostic outcome for patients with oral squamous cell carcinoma
Q34054078NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
Q28114786NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway
Q36869509NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response
Q47155954NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development.
Q39628874NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway
Q36625481Neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1, and carbohydrate antigen 19-9 in pancreatic juice: pathobiologic implications in diagnosing benign and malignant disease of the pancreas
Q93108422New Cardiovascular Biomarkers in Ischemic Heart Disease-GDF-15, A Probable Predictor for Ejection Fraction
Q37230433Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice
Q28596829Novel biomarkers for risk stratification in pulmonary arterial hypertension
Q37997237Novel biomarkers in chronic heart failure
Q37894731Novel biomarkers in human terminal heart failure and under mechanical circulatory support
Q38262569Novel serum biomarkers in pulmonary arterial hypertension
Q28538175Opposing effects of PI3K/Akt and Smad-dependent signaling pathways in NAG-1-induced glioblastoma cell apoptosis
Q41055826Over-expression of growth differentiation factor 15 (GDF15) preventing cold ischemia reperfusion (I/R) injury in heart transplantation through Foxo3a signaling.
Q45323971Over-production of growth differentiation factor 15 (GDF15) promotes human rhinovirus infection and virus-induced inflammation in the lung.
Q24620497Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway
Q34675545P38 MAPK contributes to resistance and invasiveness of HER2- overexpressing breast cancer
Q37143062PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway
Q43411896Panel of emerging cardiac biomarkers contributes for prognosis rather than diagnosis in chronic heart failure
Q58705640Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
Q73969504Placental bone morphogenetic protein (PLAB) gene expression in normal, pre-malignant and malignant human prostate: relation to tumor development and progression
Q53728725Plasma Growth Differentiation Factor-15 is a Potential Biomarker for Pediatric Pulmonary Arterial Hypertension Associated with Congenital Heart Disease
Q36446724Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women
Q33723662Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer
Q38658656Plasma cytokines can help to identify the development of severe acute pancreatitis on admission
Q37605661Plasma growth differentiation factor 15 predicts first-ever stroke in hypertensive patients
Q104681912Plasma growth differentiation factor 15: a novel tool to detect early changes of hereditary transthyretin amyloidosis
Q33932770Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy
Q61817355Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer
Q37014872Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting
Q33204505Plasticity of mouse renal collecting duct in response to potassium depletion
Q37155198Potential Markers in Cardiac Hypertrophy?
Q34577084Potentials of Plasma NGAL and MIC-1 as Biomarker(s) in the Diagnosis of Lethal Pancreatic Cancer
Q55149583Predictive value of long-term changes of growth differentiation factor-15 over a 27-year-period for heart failure and death due to coronary heart disease.
Q56524569Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes
Q40893077Profile of gene expression regulated by induced p53: connection to the TGF-beta family
Q89397554Progress in heart failure treatment in Germany
Q35872640Progressive postnatal motoneuron loss in mice lacking GDF-15.
Q36911360Prolonged NF-κB Activation by a Macrophage Inhibitory Cytokine 1-Linked Signal in Enteropathogenic Escherichia coli-Infected Epithelial Cells
Q38019709Promiscuity and specificity in BMP receptor activation
Q42435517Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells
Q33642321Prostate cancer and inflammation: the evidence
Q37087947Prostate cancer: genes, environment, immunity and the use of immunotherapy
Q35175108Prostate field cancerization: deregulated expression of macrophage inhibitory cytokine 1 (MIC-1) and platelet derived growth factor A (PDGF-A) in tumor adjacent tissue
Q56501853Protection against L3 induced Brugia malayi infection in Mastomys coucha pre-immunized with BmAFII fraction of the filarial adult worm
Q40448446Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells.
Q90974990Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species
Q36646676Quantitative analysis of macrophage inhibitory cytokine-1 (MIC-1) gene expression in human prostatic tissues
Q39128591RNPC1, an RNA-binding Protein and a p53 Target, Regulates Macrophage Inhibitory Cytokine-1 (MIC-1) Expression through mRNA Stability
Q35675385Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells
Q43125020Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate
Q53693528Reduced oxidative capacity in macrophages results in systemic insulin resistance.
Q42587600Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia
Q46220255Regulation of growth differentiation factor 15 expression by intracellular iron.
Q102388807Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
Q92714868Relationship of growth differentiation factor-15 with aortic stiffness in essential hypertension
Q47129121Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation
Q89601774Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury
Q37411797Review paper: Cancer chemopreventive compounds and canine cancer.
Q38019013Role of Urokinase Plasminogen Activator Receptor in Gastric Cancer: A Potential Therapeutic Target
Q40581135Role of viral vectors and virion shells in cellular gene expression
Q92741974Roles of Growth Differentiation Factor 15 in Atherosclerosis and Coronary Artery Disease
Q39381230Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism
Q38790569Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders
Q38909951Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease
Q92467866Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15
Q52868225Serum GDF-15 level in Behçet's disease: relationships between disease activity and clinical parameters
Q35711126Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.
Q61843304Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage
Q38166573Serum tumor markers in pancreatic cancer-recent discoveries
Q41002538Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer
Q50054012Statin Effects on Myocardial Fibrosis Markers in People Living with HIV.
Q92220231Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders
Q24564006Strategies for early detection of resectable pancreatic cancer
Q39783969Study of the association between growth differentiation factor 15 gene polymorphism and coronary artery disease in a Chinese population
Q64767710Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture
Q28505375Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant
Q53540200TAp63-dependent induction of growth differentiation factor 15 (GDF15) plays a critical role in the regulation of keratinocyte differentiation
Q36647686TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator
Q34470060TGF-beta and the regulation of neuron survival and death.
Q28481232Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer
Q58942288Targeting the Cellular “Oxygen Sensors”: Hypoxia Pre-Conditioning and Stabilization of Hypoxia-Inducible Factors
Q50026527The ABC death risk score: is it time to start measuring GDF-15?
Q34447208The Association of Growth Differentiation Factor-15 with Left Ventricular Hypertrophy in Hypertensive Patients
Q58788261The Impact of Type 2 Diabetes on Circulating Adipokines in Patients with Metabolic Syndrome
Q37228840The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation
Q37673210The Role of NAG-1/GDF15 in the Inhibition of Intestinal Polyps in APC/Min Mice by Sulindac
Q33817236The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract
Q90718919The association between serum growth differentiation factor 15 levels and lower extremity atherosclerotic disease is independent of body mass index in type 2 diabetes
Q36039060The catalytic efficiency of yeast ribonuclease III depends on substrate specific product release rate
Q35620885The correlation of serum growth differentiation factor-15 level in patients with obstructive sleep apnea
Q98157894The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling
Q35652985The development of gene therapy for diseases of the lung
Q38358925The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies
Q36592451The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer
Q34277115The effect of full length and mature NAG-1 protein overexpression on cytotoxicity of celecoxib, tamoxifen and doxorubicin in HT1080
Q38605925The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Q38115886The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1
Q40749068The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1.
Q73693575The propeptide of the transforming growth factor-beta superfamily member, macrophage inhibitory cytokine-1 (MIC-1), is a multifunctional domain that can facilitate protein folding and secretion
Q35388790The relationship of serum macrophage inhibitory cytokine-1 levels with gray matter volumes in community-dwelling older individuals.
Q36201496The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis
Q38211077The role of inflammation in prostate cancer
Q40667908The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells
Q94672733Therapeutic effect of psoralen on muscle atrophy induced by tumor necrosis factor-α
Q38335010Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice.
Q28482454Tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer: involvement of NAG-1 expression
Q64903654Towards a multi-marker prognostic strategy in acute heart failure: a role for GDF-15.
Q103044420Transcriptome analysis of pig macrophages expressing porcine reproductive and respiratory syndrome virus non-structural protein 1
Q40956039Transforming growth factor-beta1, a strong costimulator of rat T-cell activation promoting a shift towards a Th2-like cytokine profile
Q33779887Tumor Necrosis Factor Alpha Transcription in Macrophages Is Attenuated by an Autocrine Factor That Preferentially Induces NF-κB p50
Q40056643Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.
Q34493884Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells.
Q60931608Utility of GDF-15 as a diagnostic biomarker in gastric cancer: an investigation combining GEO, TCGA and meta-analysis
Q37388415Variations in NAG-1 expression of human gastric carcinoma and normal gastric tissues
Q92092600[GDF-15 in plasma and circulating mononuclear cells and NT-proBNP for diagnosis of chronic heart failure and predicting cardiovascular disease events]

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