Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes

scientific article published on 21 May 2012

Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.00231-12
P932PMC publication ID3416179
P698PubMed publication ID22615489
P5875ResearchGate publication ID225054607

P50authorCaroline S. HillQ35489136
Anassuya RamachandranQ56422665
P2093author name stringPedro Vizán
Rebecca A Randall
Isabel J Kingston
Eva Grönroos
P2860cites workBioconductor: open software development for computational biology and bioinformaticsQ21194861
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradationQ24290777
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradationQ24291000
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanismsQ24291289
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7Q24299813
Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cellsQ24306652
Stoichiometry of active smad-transcription factor complexes on DNAQ24310563
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathwaysQ24317164
Core signaling pathways in human pancreatic cancers revealed by global genomic analysesQ24606006
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancersQ24649562
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradationQ24675569
GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptorQ24676599
SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryosQ27322445
Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-  effectorsQ27659721
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signalingQ27765346
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
Summaries of Affymetrix GeneChip probe level dataQ27860888
TGFbeta signaling in growth control, cancer, and heritable disordersQ28142605
Role of transforming growth factor beta in human diseaseQ28143408
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoterQ28208212
ID proteins as targets in cancer and tools in neurobiologyQ28270836
Human Smad3 and Smad4 are sequence-specific transcription activatorsQ28276193
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
TGFbeta in CancerQ28288866
BMP7 influences proliferation, migration, and invasion of breast cancer cellsQ28299621
Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healingQ28505578
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory responseQ28512142
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor betaQ28608955
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 geneQ29616540
Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.Q33334687
Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cellsQ33924227
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.Q34193296
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibilityQ34713446
Tgf-beta superfamily signaling in embryonic development and homeostasisQ34963093
Alterations in components of the TGF-beta superfamily signaling pathways in human cancerQ36323395
How the Smads regulate transcriptionQ37025325
Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotypeQ37155797
BMP2 signaling in bone development and repairQ37628252
Spatial regulation of BMP activityQ38019713
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by SmadsQ38341189
Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activitiesQ39512965
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptorsQ39646992
Identification of BMP-responsive elements in the mouse Id2 geneQ39673246
Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responsesQ39758487
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switchQ39903519
Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growthQ39939459
Decapentaplegic-responsive silencers contain overlapping mad-binding sitesQ40257199
Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cellsQ40321110
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motifQ40442150
Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein ReceptorsQ43150619
Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.Q44475259
A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos.Q52025181
P4510describes a project that usesImageJQ1659584
limmaQ112236343
ImageQuantQ112270642
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
morphogenesisQ815547
P304page(s)2904-2916
P577publication date2012-05-21
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleTransforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes
P478volume32

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cites work (P2860)
Q34467651An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis
Q38152403BMP growth factor signaling in a biomechanical context
Q38101205Beyond TGFβ: roles of other TGFβ superfamily members in cancer
Q34572721Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.
Q36185754CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster
Q55090121Cell-cycle-dependent TGFβ-BMP antagonism regulates neural tube closure by modulating tight junctions.
Q39044519Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway.
Q38693861Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma.
Q91787755Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma
Q37639000Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling.
Q46283752Dullard/Ctdnep1 regulates endochondral ossification via suppression of TGF-β signaling
Q100378823Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract
Q37567224Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways
Q37282297GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation
Q43195204Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos.
Q37593395Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis
Q37475655Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells
Q90394704Increased activity of mesenchymal ALK2-BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues
Q35980393Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death
Q37429726MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module
Q64108169Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression
Q41062976Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina.
Q38666840Recent advances in understanding contextual TGFβ signaling
Q38076482SMAD regulatory networks construct a balanced immune system
Q38848867Signaling by TGF-betas in tubule cultures of adult rat testis
Q36947887Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state
Q33756401Strategies for exploring TGF-β signaling in Drosophila
Q36160660Structural basis for the Smad5 MH1 domain to recognize different DNA sequences
Q92883776TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation
Q47287085TGF-β signaling inhibits canonical BMP signaling pathway during palate development
Q48152733TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
Q38200065TGFβ signaling in cartilage development and maintenance
Q39155151Targeting TGF-β Signaling for Therapeutic Gain
Q37267961The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.
Q30567347The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands
Q37065891Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes
Q50104779Transforming growth factor-β in stem cells and tissue homeostasis
Q37596473Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3
Q36202520Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development
Q37684429c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression

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