Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2

scientific article

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.273.40.25628
P3181OpenCitations bibliographic resource ID146981
P698PubMed publication ID9748228
P5875ResearchGate publication ID13538141

P2093author name stringJ L Wrana
M Buchwald
S J Tang
M Macías-Silva
P A Hoodless
P2860cites workActivation of signalling by the activin receptor complexQ24308084
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signalingQ24310282
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4Q24314661
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinomaQ24315119
MADR1, a MAD-related protein that functions in BMP2 signaling pathwaysQ24317247
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptorsQ24319747
Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouseQ46227290
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathwayQ46482720
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamilyQ48064097
MAD-related proteins in TGF-beta signalling.Q52198314
Differential expression of inhibin subunits and follistatin, but not of activin receptor type II, during early murine embryonic development.Q52229140
Induction of epidermis and inhibition of neural fate by Bmp-4Q52508863
Mad about SMADsQ58983799
TGF beta signals through a heteromeric protein kinase receptor complexQ24337608
Cloning and characterization of a human type II receptor for bone morphogenetic proteinsQ24561622
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activinQ24612297
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPsQ24651958
TGF-beta signalling from cell membrane to nucleus through SMAD proteinsQ28131770
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
Mechanism of activation of the TGF-beta receptorQ28245861
Smad4 and FAST-1 in the assembly of activin-responsive factorQ28248490
Characterization of type I receptors for transforming growth factor-beta and activinQ28251169
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5Q28284508
Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4Q28288976
Signal transduction by members of the transforming growth factor-beta superfamilyQ28303118
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptorQ28507865
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2Q28511063
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptorsQ28512760
Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptorQ28580056
Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinaseQ28584256
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinaseQ28628494
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signalingQ28631440
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway componentsQ29036482
A transcriptional partner for MAD proteins in TGF-beta signallingQ29622823
XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos.Q32172187
A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificityQ33886942
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effectsQ36235769
Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complexQ36645287
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.Q36665327
Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine developmentQ36686718
TGF-beta signalling through the Smad pathwayQ36914476
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growthQ37378595
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathwayQ38349140
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signalingQ41083690
Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblastsQ41090627
Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathwayQ41104494
Inhibitory control of neural differentiation in mammalian cellsQ41111139
Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor familyQ41358724
In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvariaQ41387920
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivoQ41436510
Activin/EDF as an inhibitor of neural differentiation.Q41714120
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural inductionQ44507413
P433issue40
P407language of work or nameEnglishQ1860
P304page(s)25628-36
P577publication date1998-10-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleSpecific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
P478volume273

Reverse relations

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