Analysis of the contribution of receptor subdomains to the cooperative binding and internalization of transforming growth factor-beta (TGF-beta) type I and type II receptors

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Analysis of the contribution of receptor subdomains to the cooperative binding and internalization of transforming growth factor-beta (TGF-beta) type I and type II receptors is …
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scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2008.06.012
P698PubMed publication ID18598696

P50authorMaureen D O'Connor-McCourtQ115913394
P2093author name stringCatherine Collins
John C Zwaagstra
Marie-Josée Langlois
P2860cites workCrystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12Q22008781
Early endosomal regulation of Smad-dependent signaling in endothelial cellsQ24292399
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Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor bindingQ24310182
Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiationQ24319935
TGF beta signals through a heteromeric protein kinase receptor complexQ24337608
Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunitQ24537162
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptorQ27643809
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptorQ28139202
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Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
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Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptorQ28631183
Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase controlQ31716904
Transforming growth factor beta receptor signaling and endocytosis are linked through a COOH terminal activation motif in the type I receptorQ33946788
Growth factor receptor signalling: location, location, locationQ33960485
Structure of the ternary signaling complex of a TGF-beta superfamily memberQ34589783
The interaction of BMP-7 and ActRII implicates a new mode of receptor assemblyQ35559717
Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.Q35843298
Clathrin- and non-clathrin-mediated endocytic regulation of cell signallingQ36028155
TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2Q36324038
A pivotal role for the transmembrane domain in transforming growth factor-beta receptor activationQ38325880
Transforming growth factor beta activates Smad2 in the absence of receptor endocytosisQ40729010
Uncoupling of the cholera toxin-G(M1) ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of membrane cholesterolQ40749063
Transforming growth factor (TGF)-beta 1 internalization: modulation by ligand interaction with TGF-beta receptors types I and II and a mechanism that is distinct from clathrin-mediated endocytosisQ40805582
Down-regulation of transforming growth factor-beta receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surfaceQ40922209
Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?Q40922726
Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells.Q40971976
Somatostatin receptor desensitization in NG108-15 cells. A consequence of receptor sequestration.Q40990955
Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptorsQ41344561
Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cellsQ43771499
Distinct endocytic pathways regulate TGF-β receptor signalling and turnoverQ44419411
Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependentQ46805355
A transforming growth factor beta (TGF-beta) receptor from human placenta exhibits a greater affinity for TGF-beta 2 than for TGF-beta 1Q70143376
Extracellular domain of the transforming growth factor-beta receptor negatively regulates ligand-independent receptor activationQ73041227
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)2553-2568
P577publication date2008-06-19
P1433published inExperimental Cell ResearchQ1524289
P1476titleAnalysis of the contribution of receptor subdomains to the cooperative binding and internalization of transforming growth factor-beta (TGF-beta) type I and type II receptors
P478volume314

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Q43227527Regenerative capacity of normal and irradiated liver following partial hepatectomy in ratscites workP2860

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