BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways

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BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPLUNG.00242.2004
P8608Fatcat IDrelease_ycrwtcwxdjcpphsqnxsrneuy7y
P698PubMed publication ID15516492
P5875ResearchGate publication ID8204855

P50authorNicholas W MorrellQ60960702
Richard C TrembathQ37378213
P2093author name stringPaul D Upton
Trina K Jeffery
P2860cites workHeterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertensionQ55670914
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteinsQ24291557
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertensionQ24298704
Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.Q24540250
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signalingQ28139205
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6Q28140674
Characterization of type I receptors for transforming growth factor-beta and activinQ28251169
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expressionQ28573031
The ever-increasing complexity of TGF-beta signalingQ31032888
Adventitial fibroblasts: defining a role in vessel wall remodelingQ33806086
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II geneQ34142690
Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension.Q35044369
Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switchingQ35749008
Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growthQ35787736
A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblastsQ36237175
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family membersQ36486862
Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathwayQ38296390
Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2.Q39795032
BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1.Q40677649
Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.Q40722201
Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cellsQ40757800
Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.Q40806167
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.Q40870310
Cellular and molecular mechanisms of pulmonary vascular remodelingQ41387754
Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cellsQ42818438
Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiationQ42834807
Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical studyQ43638449
The ultrastructure of plexogenic pulmonary arteriopathyQ43767743
p27(Kip1) is important in modulating pulmonary artery smooth muscle cell proliferationQ43802288
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptorQ43952396
Alpha smooth muscle actin expression in developing and adult human lungQ44295979
Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.Q44475259
Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblastsQ44619265
Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteinsQ48066254
alpha-smooth-muscle actin and microvascular precursor smooth-muscle cells in pulmonary hypertension.Q51468191
P433issue2
P304page(s)L370-8
P577publication date2004-10-29
P1433published inAmerican Journal of Physiology - Lung Cellular and Molecular PhysiologyQ4352992
P1476titleBMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways
P478volume288