The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

scientific article published on 19 December 2015

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.6683
P932PMC publication ID4811448
P698PubMed publication ID26701726
P5875ResearchGate publication ID288001024

P50authorOla SöderbergQ39977684
Iryna VoytyukQ88509512
Karolina EdlundQ99628397
P2093author name stringCarl-Henrik Heldin
Agata Zieba
George Pyrowolakis
Aristidis Moustakas
Johan Botling
Patrick Micke
Erna Raja
Kaoru Kahata
Anita Morén
Kalliopi Tzavlaki
Yukihide Watanabe
Robin Vuilleumier
P2860cites workLIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1Q24291996
The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cellsQ24306082
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationQ24314737
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisQ24319729
Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiationQ28145299
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoterQ28208212
Bone morphogenetic protein receptors and signal transductionQ28258965
Serine/threonine phosphatases: mechanism through structureQ28263239
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeQ28307804
DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancerQ28511586
Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in DrosophilaQ28547387
Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophyQ28580464
Direct observation of individual endogenous protein complexes in situ by proximity ligationQ29616032
A rapid and sensitive bioassay to measure bone morphogenetic protein activityQ33299610
Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transitionQ33411645
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transitionQ33734595
Silencing BMP-2 expression inhibits A549 and H460 cell proliferation and migrationQ33804283
Fibrodysplasia ossificans progressiva: a blueprint for metamorphosisQ34029378
ACVR1 mutations in DIPG: lessons learned from FOP.Q34134675
CD99 is a novel prognostic stromal marker in non-small cell lung cancerQ34258877
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformationQ34527075
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarityQ34530696
Tgf-beta superfamily signaling in embryonic development and homeostasisQ34963093
Regulation of BMP and activin signaling in Drosophila.Q35673774
LKB1 and AMPK maintain epithelial cell polarity under energetic stressQ36119701
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineageQ36235105
Prevalence and specificity of LKB1 genetic alterations in lung cancersQ36277692
Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing.Q36348381
Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancerQ36740152
Wing vein patterning in Drosophila and the analysis of intercellular signalingQ36824185
TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.Q36843133
LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogasterQ36917052
Signal-induced repression: the exception or the rule in developmental signaling?Q37209023
The regulation of TGFbeta signal transductionQ37621155
Recent advances in BMP receptor signalingQ37629355
Bone Morphogenetic Proteins: A critical reviewQ37801468
Molecular mechanisms of tumor suppression by LKB1.Q37824725
The role of LKB1 in lung cancerQ37868445
BMP signaling in vascular diseasesQ38019702
Beyond TGFβ: roles of other TGFβ superfamily members in cancerQ38101205
Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1Q39640020
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory SmadsQ39791091
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switchQ39903519
Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growthQ39939459
Energy-dependent regulation of cell structure by AMP-activated protein kinaseQ40135869
Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.Q40358308
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligasesQ40437388
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.Q40560477
BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cellsQ40637159
Differential ubiquitination defines the functional status of the tumor suppressor Smad4.Q40641509
Transcriptional regulation of BMP4 synexpression in transgenic XenopusQ40734215
Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retinaQ42408221
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.Q42823613
Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein ReceptorsQ43150619
Directional transport and active retention of Dpp/BMP create wing vein patterns in Drosophila.Q45327983
Imaging Drosophila pupal wing morphogenesisQ46199709
Feedback regulation of Drosophila BMP signaling by the novel extracellular protein larval translucidaQ47071758
JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in DrosophilaQ47072494
Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing.Q52552497
Lkb1 is required for TGFbeta-mediated myofibroblast differentiation.Q54797104
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4Q72000906
Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptorsQ80310310
Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the metastatic potential of mouse breast cancer cellsQ83318737
Inhibitory machinery for the TGF-β family signaling pathwayQ95385444
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
P304page(s)1120-1143
P577publication date2015-12-19
P1433published inOncotargetQ1573155
P1476titleThe protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
P478volume7

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Q91666209AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasiscites workP2860

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