An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2

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An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JBMR.2238
P8608Fatcat IDrelease_cy2ujfq75zfurbufn6xwuzmd6m
P3181OpenCitations bibliographic resource ID463862
P932PMC publication ID4276739
P698PubMed publication ID24692083
P5875ResearchGate publication ID261299365

P2093author name stringPeter C Gray
Senyon Choe
Witek Kwiatkowski
Byung-Hak Yoon
Chihoon Ahn
Luis Esquivies
Sang-Kyu Ye
P2860cites workBone morphogenetic protein (BMP) for fracture healing in adultsQ24234838
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TGF-β and BMP signaling in osteoblast differentiation and bone formationQ26995720
Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolutionQ27617482
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactionsQ27640830
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assemblyQ27640861
BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptorsQ27648733
XDSQ27860472
REFMAC5 for the refinement of macromolecular crystal structuresQ27860905
Features and development of CootQ27861079
Identification of a binding site on the type II activin receptor for activin and inhibinQ28143632
Smad signalling networkQ28216727
Crystal structure of BMP-9 and functional interactions with pro-region and receptorsQ28246829
Bone: formation by autoinductionQ28251545
The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applicationsQ28262713
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
Designer TGFβ superfamily ligands with diversified functionalityQ28477811
A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptorsQ28506741
Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinaseQ28584256
Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect.Q33931650
Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.Q34406617
Structure of the ternary signaling complex of a TGF-beta superfamily memberQ34589783
Studies of bone morphogenetic protein-based surgical repairQ36106613
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.Q36665327
Serine/threonine kinase receptorsQ36751950
Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12.Q41069920
Activin receptors: cellular signalling by receptor serine kinasesQ41275966
High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivoQ42094508
From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transductionQ44087089
A standardized experimental fracture in the mouse tibiaQ70682553
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4Q72000906
Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidenceQ79931833
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1950-9
P577publication date2014-09-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleAn Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2
P478volume29

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cites work (P2860)
Q26739015A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives
Q58560531Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2
Q38733364Bone Morphogenetic Protein-Based Therapeutic Approaches
Q38400680Genetic Approaches To Identifying Novel Osteoporosis Drug Targets
Q31052456Investigational drugs for fracture healing: preclinical & clinical data.
Q64104312Investigational growth factors utilized in animal models of spinal fusion: Systematic review
Q38957057Structural Biology and Evolution of the TGF-β Family
Q91967330Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity
Q46017727The Cardiovascular Effect of Single Injection and Toxicologic Effects of Repetitive 2-Week Intravenous Administration of Activin A/BMP-2 Chimera in Beagle Dog.
Q46142386The activin-βA/BMP-2 chimera AB204 is a strong stimulator of adipogenesis
Q46248136The effects of a single intravenous injection of novel activin A/BMP-2 (AB204) on toxicity and the respiratory and central nervous systems
Q85455506The toxicological evaluation of repetitive 2- and 4-week intravenous injection of Activin A/BMP-2 chimera (AB204) into rats

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