p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.

scientific article published on 28 August 2009

p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.049619
P932PMC publication ID2781612
P698PubMed publication ID19717565

P2093author name stringCaterina Missero
Dario Antonini
Paul B Yu
Laura De Rosa
Rong Han
Giustina Ferone
Monia T Russo
P2860cites workp63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
Holding their own: the noncanonical roles of Smad proteinsQ24316045
TGF beta signals through a heteromeric protein kinase receptor complexQ24337608
A gene atlas of the mouse and human protein-encoding transcriptomesQ24568043
BMP type I receptor inhibition reduces heterotopic [corrected] ossificationQ24611307
Scratching the surface of skin developmentQ24647707
p63 regulates proliferation and differentiation of developmentally mature keratinocytesQ24675193
An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fateQ27349222
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoterQ28208212
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
p63 Is essential for the proliferative potential of stem cells in stratified epitheliaQ28300720
Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimerQ28302203
Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesisQ28506483
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eyeQ28508005
Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesisQ28508438
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiationQ28510156
Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63Q28510539
p63 is the molecular switch for initiation of an epithelial stratification programQ28512876
Transcripts for two members of the transforming growth factor-beta superfamily BMP-3 and BMP-7 are expressed in developing rat embryosQ28580625
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiationQ28585767
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
p63 is a p53 homologue required for limb and epidermal morphogenesisQ28588206
Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4Q28588793
p63 deficiency activates a program of cellular senescence and leads to accelerated agingQ28592969
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 geneQ29616540
HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse EmbryoQ29618704
Generation of the primary hair follicle patternQ34694802
p63 induces key target genes required for epidermal morphogenesisQ35652182
A 4.3 kb Smad7 promoter is able to specify gene expression during mouse developmentQ35751813
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signalingQ35836865
Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6)Q36232355
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effectsQ36235769
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.Q36324810
Neural induction: 10 years on since the 'default model'.Q36625558
Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineeringQ36700199
Transcriptional programs regulated by p63 in normal epithelium and tumorsQ36734663
Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.Q37387233
Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissuesQ39647327
Targeted repression of bone morphogenetic protein 7, a novel target of the p53 family, triggers proliferative defect in p53-deficient breast cancer cellsQ40073640
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cellsQ40190617
Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasisQ40248545
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.Q40297038
The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63.Q40345775
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.Q40424280
Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma.Q42833818
Bone morphogenetic proteins BMP-6 and BMP-7 have differential effects on survival and neurite outgrowth of cerebellar granule cell neuronsQ43956262
A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancerQ46417656
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth developmentQ47719322
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesisQ48073161
Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic developmentQ69123971
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4Q72000906
Smad7-induced beta-catenin degradation alters epidermal appendage developmentQ80206807
Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesisQ80862499
BMP7 is a podocyte survival factor and rescues podocytes from diabetic injuryQ81097445
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
P304page(s)30574-30582
P577publication date2009-08-28
P1433published inJournal of Biological ChemistryQ867727
P1476titlep63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.
P478volume284

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cites work (P2860)
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Q38640975p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation
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Q42198504p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis
Q28508449ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis
Q51835834ΔNp63 is regulated by BMP4 signaling and is required for early epidermal development in Xenopus.
Q37084581ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.

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