p53/p63/p73 in the epidermis in health and disease

scientific article

p53/p63/p73 in the epidermis in health and disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/CSHPERSPECT.A015248
P932PMC publication ID4109579
P698PubMed publication ID25085956

P2093author name stringElsa R Flores
Vladimir A Botchkarev
P2860cites workp63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiationQ24306117
Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor CellsQ24307750
p53 isoforms can regulate p53 transcriptional activity.Q24319034
A landscape of driver mutations in melanomaQ24603357
The DNA-damage response in human biology and diseaseQ24606586
TAp63 prevents premature aging by promoting adult stem cell maintenanceQ24618256
Epidermal homeostasis: a balancing act of stem cells in the skinQ24654755
An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fateQ27349222
Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63Q28142890
Molecular mechanisms regulating hair follicle developmentQ28200847
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progenyQ28505250
Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibitionQ28507173
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesisQ28508449
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiationQ28510156
p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tractQ28510602
p63 is the molecular switch for initiation of an epithelial stratification programQ28512876
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiationQ28585767
ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiationQ28587251
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
p63 is a p53 homologue required for limb and epidermal morphogenesisQ28588206
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermisQ28590021
A new scenario for the evolutionary origin of hair, feather, and avian scalesQ28751764
Pattern formation todayQ28751998
Asymmetric cell divisions promote stratification and differentiation of mammalian skinQ29620393
p63 and p73 transcriptionally regulate genes involved in DNA repairQ33509508
Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alphaQ33786235
The origins and evolution of the p53 family of genesQ33849403
Controls of hair follicle cyclingQ33930902
TAp63 induces senescence and suppresses tumorigenesis in vivoQ34060915
p63 in epithelial survival, germ cell surveillance, and neoplasiaQ34093062
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.Q34214054
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasisQ34273826
Diverse epigenetic strategies interact to control epidermal differentiationQ34283804
p53 Research: the past thirty years and the next thirty years.Q34313764
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAsQ34662448
DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiationQ34752036
A skin microRNA promotes differentiation by repressing 'stemness'.Q34756894
The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutationsQ34784078
SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cellsQ35015452
Covering the limb--formation of the integumentQ35066919
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Q35227440
p63-microRNA feedback in keratinocyte senescenceQ35709311
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesisQ35759101
Analysis of apoptosis during hair follicle regression (catagen)Q35764942
p53 Involvement in the control of murine hair follicle regressionQ35842211
Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophyQ36007390
The secret life of the hair follicleQ36016867
Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndromeQ36037951
Molecular principles of hair follicle induction and morphogenesisQ36043778
The cornified envelope: a model of cell death in the skinQ36085605
TAp73 depletion accelerates aging through metabolic dysregulationQ36240893
TAp63 is a master transcriptional regulator of lipid and glucose metabolismQ36353320
Asymmetric cell divisions in the epidermisQ36547115
p63-associated disorders.Q36708708
p63 in skin appendage developmentQ36723008
Mechanisms regulating epithelial stratificationQ36816002
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?Q37091735
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.Q37262994
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cellsQ37398481
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.Q37431818
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.Q37527427
Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.Q37571123
DNA-damage response in tissue-specific and cancer stem cellsQ37826528
p63, a story of mice and men.Q37862578
Targeting p73 in cancer.Q37929380
MicroRNA/mRNA regulatory networks in the control of skin development and regenerationQ37977359
Epigenetic regulation of skin: focus on the Polycomb complexQ37982255
p63/p73 in the control of cell cycle and cell death.Q37983307
Epigenetic regulation of gene expression in keratinocytesQ38024050
Hairy tale of signaling in hair follicle development and cyclingQ38039734
Chromatin regulators in mammalian epidermisQ38040245
Development and homeostasis of the sebaceous glandQ38041868
p53 mutations in cancerQ38069463
Pathobiology of chemotherapy-induced hair lossQ38078135
Mutation analysis of P73 and TP53 in Merkel cell carcinomaQ38274116
The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skinQ38329989
ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localizationQ39067694
DNA damage down-regulates ΔNp63α and induces apoptosis independent of wild type p53.Q39337973
Embryology of the epidermis: ultrastructural aspects. 1. Formation and early development in the mouse with mammalian comparisonsQ39339622
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutationsQ40198133
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesisQ41958633
The p53 family grows old.Q42253443
Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cellsQ42466132
Programming gene expression in developing epidermisQ42476595
Down-regulation of p63 is required for epidermal UV-B-induced apoptosisQ42492073
Perp is a p63-regulated gene essential for epithelial integrity.Q45345452
Fas Signaling Is Involved in the Control of Hair Follicle Response to ChemotherapyQ56990603
p53 is essential for chemotherapy-induced hair lossQ56990609
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 familyQ81662172
p63 is a useful marker for cutaneous spindle cell squamous cell carcinomaQ83999661
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell deathQ84231670
P433issue8
P577publication date2014-08-01
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titlep53/p63/p73 in the epidermis in health and disease
P478volume4

Reverse relations

cites work (P2860)
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