New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies

scientific article published on March 2011

New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/BIOF.139
P932PMC publication ID3551451
P698PubMed publication ID21488130

P2093author name stringYuji Mishina
Nobuhiro Kamiya
P2860cites workGenetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesisQ21145242
Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by nogginQ22253980
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)Q24290838
Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2Q24296798
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitorQ24303393
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomaliesQ24311933
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4Q24315313
A human chondrodysplasia due to a mutation in a TGF-beta superfamily memberQ24320410
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressivaQ24321505
Molecular recognition of BMP-2 and BMP receptor IAQ24324472
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing proteinQ24536172
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivoQ24555732
BMP type I receptor inhibition reduces heterotopic [corrected] ossificationQ24611307
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activinQ24612297
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem diseaseQ24679575
BMP receptor signaling is required for postnatal maintenance of articular cartilageQ24801945
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skinQ28190343
Identification of the ligand-binding site of the BMP type IA receptor for BMP-4Q28203953
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouseQ28204667
Receptors for the TGF-β familyQ28210923
A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch populationQ28214572
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myelomaQ28236113
Mechanism of activation of the TGF-beta receptorQ28245861
Mutations in CDMP1 cause autosomal dominant brachydactyly type CQ28248352
Bone: formation by autoinductionQ28251545
Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodelingQ28257036
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteinsQ28293474
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouseQ28296363
Bone morphogenetic proteinsQ28300236
Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypesQ28306123
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationQ28505419
Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limbQ28507152
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formationQ28507269
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eyeQ28508005
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridgeQ28511730
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac developmentQ28513337
The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryoQ28587737
Multiple roles for activin-like kinase-2 signaling during mouse embryogenesisQ28591124
Essential role of beta-catenin in postnatal bone acquisitionQ28594492
Developmental regulation of the growth plateQ29618969
Identification of progenitor cells that contribute to heterotopic skeletogenesisQ30436925
Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation.Q30440191
Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryoQ33788035
BMP signaling and early embryonic patterning.Q34416108
Endochondral ossification is required for haematopoietic stem-cell niche formationQ34902854
Function of bone morphogenetic protein signaling during mouse developmentQ35109473
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.Q35156225
A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies.Q35448192
The origins of osteoclastsQ35808029
A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN.Q35946239
The role of growth factors and related agents in accelerating fracture healingQ36486920
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathwaysQ36719098
Recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator in unstable thoracolumbar burst fractures in humans: preliminary resultsQ36725835
Endochondral ossification: how cartilage is converted into bone in the developing skeleton.Q36894947
Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2.Q37156002
Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.Q37203466
BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.Q37222697
Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclastsQ38307509
Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repairQ40289491
Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts.Q40375932
BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loopQ40621832
Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transductionQ40676346
TGFbeta signaling: receptors, transducers, and Mad proteins.Q41010880
Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligandQ42507521
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopeniaQ42801302
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signalingQ45065876
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strengthQ46186977
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.Q47764614
Graft resorption with the use of bone morphogenetic protein: lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2.Q51214225
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.Q52002102
Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.Q52002734
Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.Q52120096
Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.Q52204129
rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model.Q53311525
Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancerQ64965676
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterningQ71817916
Transcriptional mechanisms in osteoblast differentiation and bone formationQ73763993
Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone developmentQ79822578
Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidenceQ79931833
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone massQ83924358
P433issue2
P304page(s)75-82
P577publication date2011-03-01
P1433published inBioFactorsQ15767404
P1476titleNew insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies
P478volume37

Reverse relations

cites work (P2860)
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Q36757294Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeleton
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Q35435068Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1.
Q35816356Mechanical Loading Synergistically Increases Trabecular Bone Volume and Improves Mechanical Properties in the Mouse when BMP Signaling Is Specifically Ablated in Osteoblasts.
Q35740282Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms.
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Q34675005Single bout short duration fluid shear stress induces osteogenic differentiation of MC3T3-E1 cells via integrin β1 and BMP2 signaling cross-talk
Q39155183TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Q46724786The identification of loci for polydactyly in chickens using a genome-wide association study
Q90733480VWC2 Increases Bone Formation Through Inhibiting Activin Signaling