BMP receptor signaling is required for postnatal maintenance of articular cartilage

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BMP receptor signaling is required for postnatal maintenance of articular cartilage is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.0020355
P3181OpenCitations bibliographic resource ID916346
P932PMC publication ID523229
P698PubMed publication ID15492776
P5875ResearchGate publication ID8223828

P50authorMelissa E MarksQ59693949
P2093author name stringDavid M Kingsley
Hao Chen
Yuji Mishina
Ryan B Rountree
Vincent Harley
Michael Schoor
P2860cites workHeterozygous mutations in the gene encoding noggin affect human joint morphogenesisQ22009041
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancerQ22254066
A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4Q24308086
Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytesQ24323129
Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic developmentQ24337071
Association of two loci on chromosome 2q with nodal osteoarthritisQ24514854
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen geneQ24533335
Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene familyQ24561584
The human genome browser at UCSCQ24672361
Collagen of articular cartilageQ24805941
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
BMP/GDF-signalling interactions during synovial joint developmentQ28141363
Cre recombinase: the universal reagent for genome tailoringQ28145361
Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeletonQ28203665
Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitroQ28209598
Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genesQ28212192
Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesisQ28218854
Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10Q28248617
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamilyQ28251546
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related proteinQ28281538
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5Q28284508
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouseQ28296363
SOX9 directly regulates the type-II collagen geneQ28512288
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac developmentQ28513337
The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamilyQ28586944
Sox9 is required for cartilage formationQ28588649
Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study.Q50882375
Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling.Q52105931
In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb.Q52115127
Generation of Bmpr/Alk3 conditional knockout mice.Q52123530
Z/AP, a double reporter for cre-mediated recombination.Q52178130
Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.Q52198527
Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.Q52204129
Development of the diarthrodial joints in the rat embryoQ67323451
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4Q72000906
The effect of osteoarthritis on disability and health care use in CanadaQ72241290
Internucleosomal DNA fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg budQ72680701
BMP-2/-4 mediate programmed cell death in chicken limb budsQ73023240
Human articular chondrocytes express osteogenic protein-1Q73365410
Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6Q74599359
Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversityQ28593618
Cre recombinase: The universal reagent for genome tailoringQ29028530
Bone morphogenetic proteins in the development and healing of synovial jointsQ31951382
Familial aggregation of osteoarthritis: data from the Baltimore Longitudinal Study on AgingQ32054526
The transcription factors L-Sox5 and Sox6 are essential for cartilage formationQ33955940
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromesQ34020502
Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q.Q34145715
Requirement for BMP signaling in interdigital apoptosis and scale formation.Q34377113
Function of bone morphogenetic protein signaling during mouse developmentQ35109473
Regulation of osteogenic proteins by chondrocytesQ35150433
Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritisQ36273884
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilageQ36342408
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen geneQ36567842
Genetic influences on osteoarthritis in women: a twin studyQ36598099
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.Q36665327
The economic cost and social and psychological impact of musculoskeletal conditions. National Arthritis Data Work Groups.Q36683423
Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formationQ37332979
Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilageQ37367220
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birdsQ38353588
Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilageQ38360062
The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limbQ39526477
Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cells.Q40658187
Molecular structure, processing, and tissue distribution of matrilin-4.Q40816377
SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.Q40831754
TGFbeta signaling: receptors, transducers, and Mad proteins.Q41010880
JunB is involved in the inhibition of myogenic differentiation by bone morphogenetic protein-2.Q41067659
Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clonesQ41833637
Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitroQ42451491
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.Q43623240
BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb.Q43683437
Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox geneQ44019642
Immunohistochemical localization of osteogenetic protein (OP-1) and its receptors in rabbit articular cartilageQ44168346
A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lensQ46449682
Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesisQ46497845
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesisQ48073161
Specific hybridization probes for mouse type I, II, III and IX collagen mRNAsQ48222288
Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosomeQ48611307
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcartilageQ502730
Bone morphogenetic protein receptor, type 1AQ14904969
P304page(s)e355
P577publication date2004-11-01
P1433published inPLOS BiologyQ1771695
P1476titleBMP receptor signaling is required for postnatal maintenance of articular cartilage
P478volume2

Reverse relations

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