Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

scientific article

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1002610033
P356DOI10.1038/NCB1870
P932PMC publication ID2757091
P698PubMed publication ID19377468
P5875ResearchGate publication ID24308405

P2093author name stringMary C Mullins
Shawn C Little
P2860cites workp53 activation by knockdown technologiesQ21563456
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanismsQ24291289
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4Q24315313
Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptorsQ24548576
BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-IIQ24631766
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signalsQ24645277
Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolutionQ27617482
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assemblyQ27640861
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptorQ27643809
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2Q28283345
Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamilyQ28292733
Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimerQ28302203
Effective targeted gene 'knockdown' in zebrafishQ29547445
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryoQ32061709
Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation.Q32061711
BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic developmentQ33889312
Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway.Q33890835
Spemann's organizer and self-regulation in amphibian embryosQ33993579
Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.Q34391928
BMP signaling and early embryonic patterning.Q34416108
Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activityQ34445698
Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membraneQ36276659
Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing.Q36348381
Extracellular modulation of BMP activity in patterning the dorsoventral axis.Q36633269
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.Q36665327
Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning.Q40439096
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivoQ41436510
The zebrafish gene map defines ancestral vertebrate chromosomesQ42069288
The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axisQ43074864
Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutationsQ43690954
Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning.Q45138646
Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structuresQ46073558
Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryoQ47071657
zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish developmentQ47073607
Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genesQ47073791
Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activityQ47073908
Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genesQ47073994
Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryosQ47890993
In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning.Q48004761
Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafishQ48195101
Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation.Q52171177
Creating seamless junctions independent of restriction sites in PCR cloningQ71069220
Regulation of epidermal induction by BMP2 and BMP7 signalingQ73661145
P433issue5
P921main subjectmorphogenesisQ815547
BMP receptor complexQ21095329
Bone morphogenetic protein 2bQ56252047
P304page(s)637-643
P577publication date2009-04-19
P1433published inNature Cell BiologyQ1574111
P1476titleBone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis
P478volume11

Reverse relations

cites work (P2860)
Q63976740A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A
Q54107804A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma.
Q34694765ALK2 mutation in a patient with Down's syndrome and a congenital heart defect
Q33753080AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity.
Q38896053Agonists and Antagonists of TGF-β Family Ligands
Q35568492Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification
Q38945280Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis
Q37671260Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish
Q28591841Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities
Q30885621Applications of small molecule BMP inhibitors in physiology and disease
Q33576759B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo
Q47237512BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration.
Q38114048BMP signaling in telencephalic neural cell specification and maturation
Q37776859BMP signaling in vascular development and disease
Q34293026BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism
Q38364243BMP/Smad signaling and embryonic cerebellum development: stem cell specification and heterogeneity of anterior rhombic lip.
Q83227908BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis
Q27336050Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish
Q42027007Bmp signaling exerts opposite effects on cardiac differentiation
Q38620893Bmp2 controls iron homeostasis in mice independent of Bmp6.
Q35596542Bmp2 is required for odontoblast differentiation and pulp vasculogenesis
Q26746964Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury
Q37947050Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates
Q37801468Bone Morphogenetic Proteins: A critical review
Q33719268Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos
Q92823639Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA
Q43568308Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis.
Q42332006Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2.
Q30378791Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives.
Q30457781Construction of a vertebrate embryo from two opposing morphogen gradients
Q40885406Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.
Q52593116Contextual determinants of TGFβ action in development, immunity and cancer.
Q36093011Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality
Q35896949Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development
Q39674487Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and/or BMPs mimetic peptides
Q24312010Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning
Q38233800Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells
Q38538339EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning
Q38928611Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition
Q91509651Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice
Q37214103Establishment of Immortalized Mouse Bmp2 Knock-Out Dental Papilla Mesenchymal Cells Necessary for Study of Odontoblastic Differentiation and Odontogenesis
Q51907374Evolution of extracellular Dpp modulators in insects: The roles of tolloid and twisted-gastrulation in dorsoventral patterning of the Tribolium embryo.
Q35813719Fibrodysplasia ossificans progressiva: a human genetic disorder of extraskeletal bone formation, or--how does one tissue become another?
Q34644842Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis
Q27026644Fine-tuned shuttles for bone morphogenetic proteins
Q47160037Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning
Q45958654Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development.
Q33892590Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos
Q36981608Granting immunity to FOP and catching heterotopic ossification in the Act.
Q47094799Heterodimers reign in the embryo
Q35582686Inductive specification and axonal orientation of spinal neurons mediated by divergent bone morphogenetic protein signaling pathways
Q35075368Influence of bone morphogenetic protein type IA receptor conditional knockout in lens on expression of bone morphogenetic protein 4 in lens
Q36552107Inherited human diseases of heterotopic bone formation
Q33605524Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad.
Q27670456Latent TGF-β structure and activation
Q37971729Life is a pattern: vascular assembly within the embryo
Q58605164Liver iron sensing and body iron homeostasis
Q90218690Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b
Q47417320Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish.
Q42918575Meeting report - TGF-β superfamily: signaling in development and disease
Q35164712Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish
Q35983621Mutually inductive interactions between the lens and retina require ALK3 functions during mouse embryonic development
Q34651389Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish
Q28069613Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors
Q33808497Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development
Q35483789Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
Q47434187Prodomain-Growth Factor Swapping in the Structure of pro-TGF-β1.
Q33750470Rapid evolution of a novel signalling mechanism by concerted duplication and divergence of a BMP ligand and its extracellular modulators
Q50042943Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.
Q38019713Spatial regulation of BMP activity
Q91812737Specification of BMP Signaling
Q91943837Specificity, versatility, and control of TGF-β family signaling
Q36743865Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis
Q33756401Strategies for exploring TGF-β signaling in Drosophila
Q38957057Structural Biology and Evolution of the TGF-β Family
Q90633876Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family
Q38615917Systems biology derived source-sink mechanism of BMP gradient formation
Q38733048TGF-β Family Signaling in Early Vertebrate Development
Q90631766TGF-β Signaling
Q38824306TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
Q26783734Targeting BMP signalling in cardiovascular disease and anaemia
Q26827564Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes
Q89737690The BMP ligand Pinhead together with Admp supports the robustness of embryonic patterning
Q34020080The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling
Q92923287The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases
Q47279346The TGFβ superfamily in Lisbon: navigating through development and disease
Q37403100The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization
Q27320128The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis
Q38106873The multiple activities of BMPs during spinal cord development.
Q35590158The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo
Q27656789The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding
Q30567347The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands
Q41063018Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1.
Q37296203Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex
Q47447929Variable signaling activity by FOP ACVR1 mutations
Q50144496Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish
Q47775830Vegetally localised Vrtn functions as a novel repressor to modulate bmp2b transcription during dorsoventral patterning in zebrafish.
Q61443332Venous identity requires BMP signalling through ALK3
Q47135848Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm
Q33820568Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis
Q39976632Zygotic LvBMP5-8 is required for skeletal patterning and for left-right but not dorsal-ventral specification in the sea urchin embryo.

Search more.