TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration

scientific article published on 27 November 2015

TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MATBIO.2015.11.008
P932PMC publication ID4808357
P698PubMed publication ID26639428

P2093author name stringJun Li
Chao Liu
Hua Wang
Wen Yuan
Ye Tian
Irving M Shapiro
Makarand V Risbud
Maxwell G Hunt
P2860cites workNucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironmentQ46891204
Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosisQ47578416
Regulation of cellular adhesion to extracellular matrix proteins by galectin-3.Q47999828
Magnetic resonance classification of lumbar intervertebral disc degeneration.Q48737575
Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling.Q50479987
Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy.Q51808840
Galectin-3 expression in the intervertebral disc: a useful marker of the notochord phenotype?Q51997733
The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2)Q68768239
Galectin-3 regulates the adhesive interaction between breast carcinoma cells and elastinQ73119195
Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 familyQ73931768
Intracellular localisation of galectin-3 has a protective role in chondrocyte survivalQ80421385
HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral discQ80530258
Elevated production of galectin-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progressionQ82055314
Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritisQ83328154
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradationQ24290777
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formationQ24302554
Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordomaQ24324165
Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectinQ24533183
Role of cytokines in intervertebral disc degeneration: pain and disc contentQ27001658
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3Q28575305
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral discQ30423879
Extracellular matrix in disc degenerationQ33238918
Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc diQ34299937
Structure and function of the notochord: an essential organ for chordate developmentQ34418493
Mechanobiology of the intervertebral disc and relevance to disc degenerationQ34510529
Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signalingQ34696270
Role of elastin-matrix interactions in tumor progressionQ34706657
BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKsQ35157807
Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activityQ36812375
Downregulated interleukin 37 expression associated with aggravation of intervertebral disc degenerationQ37587376
CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degenerationQ37635765
Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathwaysQ37690081
Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissuesQ38097283
S-type mammalian lectins in allergic inflammationQ38315519
Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' responseQ38329243
Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectinQ38329488
Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus.Q38493940
Galectin-3 inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by activating Akt in human bladder carcinoma cells.Q40377941
Endogenous galectin-3 determines the routing of CD95 apoptotic signaling pathways.Q40554460
Expression of galectin-3 in skeletal tissues is controlled by Runx2.Q40668407
Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitroQ41320187
Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathwaysQ42077799
Galectin 3 and its binding protein in rheumatoid arthritis.Q42451393
Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc diseaseQ42507600
Galectin-3 mediates the endocytosis of beta-1 integrins by breast carcinoma cellsQ43816780
P304page(s)39-52
P577publication date2015-11-27
P1433published inMatrix BiologyQ6787851
P1476titleTGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration
P478volume50

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cites work (P2860)
Q52615758A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis.
Q88487617COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells
Q33620702Correlation Between Expression of High Temperature Requirement Serine Protease A1 (HtrA1) in Nucleus Pulposus and T2 Value of Magnetic Resonance Imaging
Q64068657Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment
Q52602287Extracellular matrix: The driving force of mammalian diseases.
Q37508714Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis
Q92210847Galectins-1 and -3 in Human Intervertebral Disc Degeneration: Non-Uniform Distribution Profiles and Activation of Disease Markers Involving NF-κB by Galectin-1
Q87947877Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration
Q98778906High-dose TGF-β1 degrades human nucleus pulposus cells via ALK1-Smad1/5/8 activation
Q100513942Role of AP-2α/TGF-β1/Smad3 axis in rats with intervertebral disc degeneration
Q92645917TGF-β1 suppresses syndecan-2 expression through the ERK signaling pathway in nucleus pulposus cells

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