| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/JCB.20765 |
| P8608 | Fatcat ID | release_yxgydoh23vf3vihfen5vckjlca |
| P698 | PubMed publication ID | 16408279 |
| P2093 | author name string | Irving M Shapiro | |
| Makarand V Risbud | |||
| Todd J Albert | |||
| David Hawkins | |||
| Thomas P Schaer | |||
| Asha Guttapalli | |||
| David G Stokes | |||
| Keith G Danielson | |||
| P433 | issue | 1 | |
| P921 | main subject | metabolic adaptation | Q47171912 |
| P304 | page(s) | 152-159 | |
| P577 | publication date | 2006-05-01 | |
| P1433 | published in | Journal of Cellular Biochemistry | Q6294917 |
| P1476 | title | Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment | |
| P478 | volume | 98 |
| Q35868717 | 3D finite element analysis of nutrient distributions and cell viability in the intervertebral disc: effects of deformation and degeneration |
| Q40177444 | A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat. |
| Q42868510 | Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc |
| Q42586123 | An in vitro investigation into the role of bone marrow‑derived mesenchymal stem cells in the control of disc degeneration |
| Q92970239 | An optimized culture system for notochordal cell expansion with retention of phenotype |
| Q35828477 | Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells |
| Q35157807 | BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs |
| Q28567959 | Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc |
| Q47936637 | Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells |
| Q37635765 | CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration |
| Q88487617 | COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells |
| Q37376474 | Cell signaling pathways related to pain receptors in the degenerated disk |
| Q54941293 | Cell therapy for intervertebral disc repair: Clinical perspective. |
| Q90467608 | CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis |
| Q41133336 | Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health |
| Q52590898 | Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. |
| Q36963704 | Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc |
| Q47386516 | Comparison of nucleus pulposus stem/progenitor cells isolated from degenerated intervertebral discs with umbilical cord derived mesenchymal stem cells |
| Q98157710 | Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain |
| Q35447013 | Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting |
| Q26823083 | Diversity of intervertebral disc cells: phenotype and function |
| Q41446833 | EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture |
| Q35186692 | Effects of hypoxias and scaffold architecture on rabbit mesenchymal stem cell differentiation towards a nucleus pulposus-like phenotype |
| Q58749034 | Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease |
| Q55052402 | Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. |
| Q34396203 | Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs |
| Q35956449 | Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia |
| Q53252239 | Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments. |
| Q33947033 | FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells |
| Q35908533 | FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of the Intervertebral Disc |
| Q37324319 | Future perspectives of cell-based therapy for intervertebral disc disease |
| Q87947877 | Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration |
| Q30393730 | HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells |
| Q35678327 | HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc |
| Q34525641 | HIF-1α polymorphism in the susceptibility of cervical spondylotic myelopathy and its outcome after anterior cervical corpectomy and fusion treatment |
| Q39475834 | Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease |
| Q37371593 | Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling |
| Q51055494 | Hypoxia suppresses serum deprivation-induced degradation of the nucleus pulposus cell extracellular matrix through the JNK and NF-κB pathways. |
| Q92645070 | Hypoxia-inducible factor (HIF)-1alpha knockout accelerates intervertebral disc degeneration in mice |
| Q36812375 | Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity |
| Q28576490 | Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc |
| Q52577117 | Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. |
| Q35534857 | Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture |
| Q37687706 | Hypoxic regulation of nucleus pulposus cell survival: from niche to notch |
| Q35074481 | Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins |
| Q37105460 | Identification of novel nucleus pulposus markers: Interspecies variations and implications for cell-based therapiesfor intervertebral disc degeneration. |
| Q41228270 | Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. |
| Q28583559 | Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration |
| Q93089875 | Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats |
| Q33867011 | Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus |
| Q45831064 | Lactate down-regulates matrix systhesis and promotes apoptosis and autophagy in rat nucleus pulposus cells |
| Q48097962 | LncRNA-RP11-296A18.3/miR-138/HIF1A Pathway Regulates the Proliferation ECM Synthesis of Human Nucleus Pulposus Cells (HNPCs). |
| Q34388621 | Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus. |
| Q27687808 | Mechanical design criteria for intervertebral disc tissue engineering |
| Q38116401 | Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level. |
| Q39245619 | Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function |
| Q42542587 | Mesenchymal stem cell for prevention and management of intervertebral disc degeneration |
| Q37620716 | MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells |
| Q91329591 | Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy |
| Q26764941 | Molecular mechanisms of biological aging in intervertebral discs |
| Q38097283 | Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues |
| Q91846231 | NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis |
| Q54405532 | Normoxic Expression of Hypoxia‐Inducible Factor 1 in Rat Leydig Cells In Vivo and In Vitro |
| Q93087746 | Nuclear factor-kappa B-dependent X-box binding protein 1 signalling promotes the proliferation of nucleus pulposus cells under tumour necrosis factor alpha stimulation |
| Q36771759 | Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction? |
| Q90999547 | Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation |
| Q30434295 | Nucleus pulposus tissue engineering: a brief review |
| Q28582270 | Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc |
| Q47120036 | Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways. |
| Q51007532 | PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis. |
| Q34589291 | PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc |
| Q37190806 | Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin α1 and phosphorylation of downstream phospholipase Cγ1 |
| Q31133556 | Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort |
| Q90331180 | Pooled Platelet-Rich Plasma Lysate Therapy Increases Synoviocyte Proliferation and Hyaluronic Acid Production While Protecting Chondrocytes From Synoviocyte-Derived Inflammatory Mediators |
| Q47277568 | Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells. |
| Q41583520 | Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype |
| Q36407793 | Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling |
| Q30360231 | Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. |
| Q92970196 | Promise, progress, and problems in whole disc tissue engineering |
| Q34731289 | Protective effect of carboxymethylated chitosan on hydrogen peroxide-induced apoptosis in nucleus pulposus cells |
| Q49411461 | RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? |
| Q47262108 | RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues. |
| Q39289681 | Radiation protective effect of hypoxia-inducible factor-1α (HIF-1α) on human oral squamous cell carcinoma cell lines |
| Q37201468 | Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies |
| Q38069178 | Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration. |
| Q37813503 | Regeneration potential and mechanism of bone marrow mesenchymal stem cell transplantation for treating intervertebral disc degeneration |
| Q34696270 | Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling |
| Q36872795 | Regulatory role of hypoxia inducible factor in the biological behavior of nucleus pulposus cells |
| Q35916880 | Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc |
| Q37197284 | SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc |
| Q48204278 | Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration. |
| Q42507600 | Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease |
| Q38364573 | Stem cell therapy for intervertebral disc regeneration: obstacles and solutions |
| Q87265054 | Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease |
| Q50213453 | Systematic study of cell isolation from bovine nucleus pulposus: Improving cell yield and experiment reliability. |
| Q38728066 | TGF-β Stimulates Expression of Chondroitin Polymerizing Factor in Nucleus Pulposus Cells Through the Smad3, RhoA/ROCK1, and MAPK Signaling Pathways. |
| Q39521876 | TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration |
| Q30423879 | TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc |
| Q47904196 | TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells |
| Q91462541 | The Intervertebral Disc: Physiology and Pathology of a Brittle Joint |
| Q41339364 | The PI3K/Akt pathway: a critical player in intervertebral disc degeneration |
| Q39941958 | The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease |
| Q57455087 | The involvement of regulated in development and DNA damage response 1 (REDD1) in the pathogenesis of intervertebral disc degeneration |
| Q38136600 | The pain of tendinopathy: physiological or pathophysiological? |
| Q41821171 | Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1α degradation |
| Q40726927 | Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes |
| Q52670066 | Transcriptome and alternative splicing analysis of nucleus pulposus cells in response to high oxygen tension: Involvement of high oxygen tension in the pathogenesis of intervertebral disc degeneration. |
| Q35195070 | Transforming growth factor β controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. |
| Q43239473 | Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. |
| Q34299937 | Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc di |
| Q35624993 | Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration |
| Q38069235 | Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies. |
| Q35008504 | Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. |
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