Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc

scientific article published on 15 January 2009

Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M807081200
P932PMC publication ID2665104
P698PubMed publication ID19147493
P5875ResearchGate publication ID23791438

P2093author name stringDaisuke Sakai
Joji Mochida
Irving M Shapiro
Makarand V Risbud
Akihiko Hiyama
Sachin Gajghate
P2860cites workStimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repairQ24558762
The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent mannerQ28142037
Evidence of calcium-dependent pathway in the regulation of human beta1,3-glucuronosyltransferase-1 (GlcAT-I) gene expression: a key enzyme in proteoglycan synthesisQ28249133
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activationQ29620223
Transcriptional regulation by calcium, calcineurin, and NFATQ29620410
Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytesQ32067938
Extracellular matrix in disc degenerationQ33238918
Mechanobiology of the intervertebral disc and relevance to disc degenerationQ34510529
How tonicity regulates genes: story of TonEBP transcriptional activatorQ36492526
TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicityQ39675201
Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stressQ40196863
Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cellsQ40556250
Chinese hamster ovary cell mutants defective in glycosaminoglycan assembly and glucuronosyltransferase I.Q41649103
Ras regulates NFAT3 activity in cardiac myocytesQ43508628
Effect of calcium channel blockers on proteoglycan synthesis by vascular smooth muscle cells and low density lipoprotein--proteoglycan interactionQ43687620
NFAT1 and NFAT2 are positive regulators of IL-4 gene transcriptionQ44159701
Increases in cytosolic calcium, but not fluid flow, affect aggrecan mRNA levels in articular chondrocytesQ44660146
Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.Q45044196
Calcium signaling is required for ultrasound-stimulated aggrecan synthesis by rat chondrocytesQ45711941
Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironmentQ46891204
Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy.Q51808840
Developmental changes in serum UDP-GlcA:chondroitin glucuronyltransferase activity.Q52202311
Inhibition of transmembrane calcium influx induces decrease in proteoglycan synthesis in immature rat Sertoli cellsQ73318813
MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBPQ79981860
HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral discQ80530258
TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral discQ83986148
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)9824-9834
P577publication date2009-01-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleActivation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
P478volume284