| scholarly article | Q13442814 |
| P2093 | author name string | Nobuyuki Fujita | |
| Irving M Shapiro | |||
| Kazuhiro Chiba | |||
| Makarand V Risbud | |||
| P2860 | cites work | The Human Intervertebral Disc: A Micro-Angiographical Study on Its Vascular Supply at Various Ages | Q58076333 |
| Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor | Q64005208 | ||
| Lymph and blood supply of the human intervertebral disc. Cadaver study of correlations to discitis | Q70606050 | ||
| Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk | Q80177979 | ||
| Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc | Q82735380 | ||
| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
| Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 | Q24320257 | ||
| Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element | Q24528175 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor | Q28271379 | ||
| Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin | Q28508440 | ||
| Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2 | Q28508549 | ||
| Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia | Q28586744 | ||
| Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice | Q28594703 | ||
| Potential therapeutic applications of autophagy | Q29622862 | ||
| Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain | Q32127020 | ||
| COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70. | Q33508581 | ||
| Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha | Q33662015 | ||
| Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes | Q33966774 | ||
| Histology and pathology of the human intervertebral disc | Q34510523 | ||
| A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. | Q34588182 | ||
| Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity | Q35141643 | ||
| Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure | Q36491882 | ||
| Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy | Q37353821 | ||
| Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. | Q38312685 | ||
| HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells | Q39677346 | ||
| RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha | Q40179965 | ||
| Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. | Q40626158 | ||
| Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells | Q41031244 | ||
| Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene | Q42092346 | ||
| Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. | Q44055318 | ||
| Mammalian EGLN genes have distinct patterns of mRNA expression and regulation | Q44137583 | ||
| Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat. | Q46829108 | ||
| Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment | Q46891204 | ||
| Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. | Q51907850 | ||
| The expression of hypoxia inducible factor-1alpha and apoptosis in herniated discs. | Q53621308 | ||
| Expression and function of TbetaRII-B, a variant of the type II TGF-beta receptor, in human chondrocytes. | Q54566748 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 401-412 | |
| P577 | publication date | 2012-02-01 | |
| P1433 | published in | Journal of Bone and Mineral Research | Q15750941 |
| P1476 | title | HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc | |
| P478 | volume | 27 |
| Q35828477 | Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells |
| Q47936637 | Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells |
| Q37376474 | Cell signaling pathways related to pain receptors in the degenerated disk |
| Q50054942 | Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction. |
| Q41133336 | Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health |
| Q92425714 | Cirsium japonicum var. maackii and apigenin block Hif-2α-induced osteoarthritic cartilage destruction |
| Q36963704 | Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc |
| Q36431785 | Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation |
| Q90402524 | Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch |
| Q35447013 | Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting |
| Q58749034 | Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease |
| Q36255223 | Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration |
| Q55052402 | Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. |
| Q35956449 | Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia |
| Q33947033 | FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells |
| Q87947877 | Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration |
| Q30393730 | HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells |
| Q34525641 | HIF-1α polymorphism in the susceptibility of cervical spondylotic myelopathy and its outcome after anterior cervical corpectomy and fusion treatment |
| Q36543040 | HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer |
| Q37371593 | Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling |
| Q36812375 | Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity |
| Q33867011 | Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus |
| Q41022521 | MCPIP1 contributes to clear cell renal cell carcinomas development |
| Q26764941 | Molecular mechanisms of biological aging in intervertebral discs |
| Q38097283 | Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues |
| Q53170801 | PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study. |
| Q51007532 | PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis. |
| Q31133556 | Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort |
| Q36407793 | Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling |
| Q30360231 | Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. |
| Q36872795 | Regulatory role of hypoxia inducible factor in the biological behavior of nucleus pulposus cells |
| Q50472143 | SHH-dependent knockout of HIF-1 alpha accelerates the degenerative process in mouse intervertebral disc. |
| Q35624993 | Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration |
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