Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells

scientific article published in May 2015

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.3631
P932PMC publication ID4494915
P698PubMed publication ID25844601
P5875ResearchGate publication ID274570855

P50authorAshley A. ColeQ79363091
P2093author name stringIrving M Shapiro
Makarand V Risbud
Zariel I Johnson
Shilpa S Gogate
Rebecca Day
Dessislava Z Markova
Christine L Le Maitre
Neil Chiverton
Abbie Binch
Matt Conner
P2860cites workActivation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
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2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injuryQ27863416
Aquaporin expression in the human intervertebral discQ28267267
Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral discQ28582270
FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cellsQ33947033
T1ρ magnetic resonance imaging and discography pressure as novel biomarkers for disc degeneration and low back painQ34167386
Transcriptional regulation of aquaporins in the ischemic rat retina: upregulation of aquaporin-9.Q34266154
Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stressQ34574130
Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1α and proteasome-mediated pathwaysQ34613109
Aquaporin water channels--from atomic structure to clinical medicineQ34719800
Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteinsQ35074481
HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral discQ35678327
From structure to disease: the evolving tale of aquaporin biologyQ35875999
Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxiaQ35956449
Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrixQ35963853
Regulation and function of aquaporin-1 in glioma cellsQ36012580
Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1Q36178060
Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activityQ36812375
Matrix synthesis and degradation in human intervertebral disc degeneration.Q36883824
The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain.Q37293616
CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degenerationQ37635765
Diffusion of small solutes into the intervertebral disc: as in vivo studyQ39214711
Hypoxia-induced up-regulation of aquaporin-1 protein in prostate cancer cells in a p38-dependent mannerQ39380390
Aquaporin-4 in the heart: expression, regulation and functional role in ischemiaQ39589178
The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.Q39678716
Expression of aquaporin 1 (AQP1) in human synovitisQ39901480
Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1α degradationQ41821171
Aggrecan degradation in human intervertebral disc and articular cartilageQ42987526
Hypoxia-inducible factor-1alpha signaling in aquaporin upregulation after traumatic brain injuryQ43104184
Distribution and diffusion of solutes in articular cartilageQ43105539
The correlation of fixed negative charge with glycosaminoglycan content of human articular cartilageQ43465844
Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2.Q44055318
The role of the hypoxia-inducible factor 1 binding site in the induction of aquaporin-1 mRNA expression by hypoxiaQ44174553
Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alphaQ45029269
Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironmentQ46891204
AQP1 expression alterations affect morphology and water transport in Schwann cells and hypoxia-induced up-regulation of AQP1 occurs in a HIF-1α-dependent mannerQ47772691
AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuriesQ47841570
Aquaporin-1: a potential membrane channel for facilitating the adaptability of rabbit nucleus pulposus cells to an extracellular matrix environment.Q51875166
Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.Q54238038
Exploring gas permeability of cellular membranes and membrane channels with molecular dynamicsQ57233405
The Human Intervertebral Disc: A Micro-Angiographical Study on Its Vascular Supply at Various AgesQ58076333
Development of Cytosolic Hypoxia and Hypoxia-inducible Factor Stabilization Are Facilitated by Aquaporin-1 ExpressionQ61855672
Water and electrolyte content of human intervertebral discs under variable loadQ70079432
Lymph and blood supply of the human intervertebral disc. Cadaver study of correlations to discitisQ70606050
Water channels in chondrocyte function: another 'unexpected' role of aquaporinsQ80117283
Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral diskQ80177979
HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral discQ80530258
Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral discQ82735380
Temporal alterations in aquaporin and transcription factor HIF1α expression following penetrating ballistic-like brain injury (PBBI)Q87760198
P4510describes a project that usesImageQuantQ112270642
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)11945-11958
P577publication date2015-05-01
P1433published inOncotargetQ1573155
P1476titleAquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells
P478volume6

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cites work (P2860)
Q92970331Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration
Q41133336Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health
Q26783031Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration
Q47125223Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues
Q36946736Expression of aquaporin1, a water channel protein, in cytoplasm is negatively correlated with prognosis of breast cancer patients
Q41339657Formation, function, and exhaustion of notochordal cytoplasmic vacuoles within intervertebral disc: current understanding and speculation
Q47739990Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression.
Q92542938NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia
Q57729296The potential of CRISPR/Cas9 genome editing for the study and treatment of intervertebral disc pathologies

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