| scholarly article | Q13442814 |
| P50 | author | Christopher K Kepler | Q108757190 |
| P2093 | author name string | Irving M Shapiro | |
| D Greg Anderson | |||
| Makarand V Risbud | |||
| Zachary R Schoepflin | |||
| Dessislava Z Markova | |||
| Cassie M Tran | |||
| P2860 | cites work | CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB. | Q39855226 |
| Chromatin-dependent E1A activity modulates NF-kappaB RelA-mediated repression of glucocorticoid receptor-dependent transcription | Q40489501 | ||
| Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. | Q41228270 | ||
| CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes | Q42013999 | ||
| Immunological characterization of eristostatin and echistatin binding sites on alpha IIb beta 3 and alpha V beta 3 integrins | Q42249278 | ||
| Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease | Q42507600 | ||
| Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc | Q42909500 | ||
| Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling | Q43042667 | ||
| CTGF induces monocyte chemoattractant protein-1 expression to enhance monocyte migration in human synovial fibroblasts | Q43555114 | ||
| Expression and role of connective tissue growth factor in painful disc fibrosis and degeneration | Q44046024 | ||
| Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). | Q44961475 | ||
| Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs | Q46140203 | ||
| Expression of integrin subunits in the herniated intervertebral disc | Q46196786 | ||
| Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment | Q46891204 | ||
| Interleukin‐1β induces angiogenesis and innervation in human intervertebral disc degeneration | Q48097972 | ||
| Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. | Q51062139 | ||
| Nucleus pulposus notochord cells secrete connective tissue growth factor and up-regulate proteoglycan expression by intervertebral disc chondrocytes. | Q51099346 | ||
| Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration | Q59683291 | ||
| Analysis of Tissue Distribution of TNF- , TNF- -Receptors, and the Activating TNF- -Converting Enzyme Suggests Activation of the TNF- System in the Aging Intervertebral Disc | Q63341133 | ||
| Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage | Q64377854 | ||
| Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways | Q81377115 | ||
| Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites | Q81515834 | ||
| Fibronectin fragment activation of ERK increasing integrin α₅ and β₁ subunit expression to degenerate nucleus pulposus cells | Q83452322 | ||
| Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts | Q22254093 | ||
| CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1 | Q24303627 | ||
| Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development | Q24616861 | ||
| Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines | Q24803888 | ||
| Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan | Q28235118 | ||
| N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan | Q28238572 | ||
| Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival | Q28576901 | ||
| Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2 | Q28590011 | ||
| TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc | Q30423879 | ||
| Extracellular matrix in disc degeneration | Q33238918 | ||
| Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor | Q33537427 | ||
| Spatial-temporal modulation of CCN proteins during wound healing in human skin in vivo | Q33870000 | ||
| Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues | Q34050359 | ||
| Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein | Q34487143 | ||
| CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway | Q34507247 | ||
| Mechanobiology of the intervertebral disc and relevance to disc degeneration | Q34510529 | ||
| Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling | Q34696270 | ||
| Transforming growth factor β controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. | Q35195070 | ||
| Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation | Q35683028 | ||
| Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. | Q36392389 | ||
| Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling | Q36407793 | ||
| CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes | Q36496112 | ||
| Degenerative grade affects the responses of human nucleus pulposus cells to link-N, CTGF, and TGFβ3. | Q36544996 | ||
| Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta | Q36663630 | ||
| Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity | Q36812375 | ||
| Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-kappaB activation | Q38313230 | ||
| Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes | Q39474413 | ||
| P4510 | describes a project that uses | ImageQuant | Q112270642 |
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | interleukins | Q194908 |
| P304 | page(s) | 7374-7387 | |
| P577 | publication date | 2014-01-24 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration | |
| P478 | volume | 289 |
| Q52615758 | A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. |
| Q35828477 | Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells |
| Q89967485 | Biomaterials-Induced Stem Cells Specific Differentiation Into Intervertebral Disc Lineage Cells |
| Q58795684 | CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt-β-catenin signaling in nucleus pulposus cells |
| Q26751449 | Cell surface receptors for CCN proteins |
| Q38695375 | Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells |
| Q35447013 | Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting |
| Q28390520 | Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics |
| Q26783031 | Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration |
| Q38631831 | Discovery of the drivers of inflammation induced chronic low back pain: from bacteria to diabetes |
| Q38651479 | Effects of CCN3 on rat cartilage endplate chondrocytes cultured under serum deprivation in vitro |
| Q45981837 | Ghrelin protects against nucleus pulposus degeneration through inhibition of NF-κB signaling pathway and activation of Akt signaling pathway. |
| Q47874703 | Inflammatory cytokines induce caveolin-1/β-catenin signalling in rat nucleus pulposus cell apoptosis through the p38 MAPK pathway |
| Q92313281 | Ligustrazine Prevents Intervertebral Disc Degeneration via Suppression of Aberrant TGFβ Activation in Nucleus Pulposus Cells |
| Q42314948 | Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis |
| Q37728750 | Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus |
| Q37190806 | Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin α1 and phosphorylation of downstream phospholipase Cγ1 |
| Q36972672 | Progranulin knockout accelerates intervertebral disc degeneration in aging mice |
| Q38711724 | Pullulan microbeads/Si-HPMC hydrogel injectable system for the sustained delivery of GDF-5 and TGF-β1: new insight into intervertebral disc regenerative medicine. |
| Q92511862 | Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway |
| Q38691982 | Regulation of human nucleus pulposus cells by peptide-coupled substrates. |
| Q37111035 | SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc. |
| Q36923621 | Syndecan-4 in intervertebral disc and cartilage: Saint or synner? |
| Q39521876 | TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration |
| Q53666486 | TNF-α and TGF-β1 regulate Syndecan-4 expression in nucleus pulposus cells: role of the mitogen-activated protein kinase and NF-κB pathways. |
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