CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.

scientific article

CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1681/ASN.2008090999
P932PMC publication ID2709681
P698PubMed publication ID19423687

P50authorMarta Ruiz-OrtegaQ56616783
Juan Rodriguez-VitaQ58774280
Sandra Rayego-MateosQ59704892
Elsa Sanchez-LopezQ61162439
P2093author name stringAlberto Ortiz
Jesús Egido
Raquel Rodrigues-Díez
Rafael Selgas
Sergio A Mezzano
Luiz Stark Aroeira
Gisselle Carvajal
Javier Sánchez Rodriguez
Raúl Rodrigues-Díez
P2860cites workActivation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cellsQ24815319
Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathwaysQ27863390
Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkAQ28298502
IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal diseaseQ28574673
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseasesQ29547555
Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitroQ33212781
Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cellsQ33251736
The CCN family of angiogenic regulators: the integrin connectionQ33545691
Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosisQ34050059
Transcription factor-kappa B (NF-kappa B) and renal disease.Q34135831
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.Q34505685
Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritisQ35789327
Angiotensin II increases connective tissue growth factor in the kidney.Q35843514
Identification and characterization of a fibroblast marker: FSP1Q36382596
Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes.Q36661077
The role of chemokines and chemokine receptors in diabetic nephropathyQ36991984
The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation.Q37280352
Induction, function and regulation of IL-17-producing T cellsQ37311131
Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cellsQ40133623
Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.Q40242733
Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1.Q40255157
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytesQ40326104
Reactive oxygen species-mediated signaling pathways in angiotensin II-induced MCP-1 expression of proximal tubular cells.Q40382593
NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinaseQ40432734
Role of connective tissue growth factor in renal tubular epithelial-myofibroblast transdifferentiation and extracellular matrix accumulation in vitroQ40557517
Interferon-gamma induces macrophage migration inhibitory factor synthesis and secretion by tubular epithelial cells.Q40580288
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK).Q40765291
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.Q41062073
The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells.Q44129438
Plasma connective tissue growth factor is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathyQ44617933
In vivo administration of a nuclear transcription factor-kappaB decoy suppresses experimental crescentic glomerulonephritis.Q44688666
Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction.Q44903329
Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusionQ45168898
Molecular insights into connective tissue growth factor action in rat pancreatic stellate cellsQ46474579
Effect of silencing connective tissue growth factor on rat liver fibrosis and the accumulation of extracellular matrixQ46684349
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failureQ46705065
Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cellsQ46891070
IL-4 and IL-13 augment cytokine- and CD40-induced RANTES production by human renal tubular epithelial cells in vitroQ47917213
Renal expression of IL-6 and TNFalpha genes in lupus nephritisQ48024829
Suppression of cell proliferation and signaling transduction by connective tissue growth factor in non-small cell lung cancer cells.Q51153671
TGF-beta1 and CTGF mRNAs are correlated with urinary protein level in IgA nephropathy.Q53499066
Cytokine balance in kidney tissue from lupus nephritis patientsQ53655942
Connective tissue growth factor is responsible for transforming growth factor-beta-induced peritoneal mesothelial cell apoptosis.Q54606047
Connective Tissue Growth Factor Expressed in Tubular Epithelium Plays a Pivotal Role in Renal FibrogenesisQ57691320
Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosisQ61648789
Inhibitory effect of interleukin-1β on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cellsQ61854905
Angiotensin IV Activates the Nuclear Transcription Factor-κB and Related Proinflammatory Genes in Vascular Smooth Muscle CellsQ61854944
Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathyQ62504236
Expression of interleukin 6 and major histocompatibility complex molecules in tubular epithelial cells of diseased human kidneysQ72832749
Tubular epithelial cells: A critical cell type in the regulation of renal inflammatory processesQ73177067
Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritisQ73395940
Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritisQ73867315
Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr miceQ74410142
Tubular NF-kappaB and AP-1 activation in human proteinuric renal diseaseQ74566827
Interleukin 4 co-stimulates the PDGF-BB- and bFGF-mediated proliferation of mesangial cells and myofibroblastsQ78425901
Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cellsQ79781731
Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6Q79808046
NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathyQ80389149
Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetesQ80441677
Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancerQ83862044
Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosisQ95811801
P433issue7
P921main subjectNF-κBQ411114
inflammationQ101991
P304page(s)1513-1526
P577publication date2009-05-07
P1433published inJournal of the American Society of NephrologyQ17123893
P1476titleCTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB
P478volume20

Reverse relations

cites work (P2860)
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Q33795658Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis
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Q26779818CCN: core regulatory proteins in the microenvironment that affect the metastasis of hepatocellular carcinoma?
Q34720176CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia
Q58798857CTGF in kidney fibrosis and glomerulonephritis
Q39493006CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy
Q91998745Connective Tissue Growth Factor Is Related to All-cause Mortality in Hemodialysis Patients and Is Lowered by On-line Hemodiafiltration: Results from the Convective Transport Study
Q42776466Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium
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Q49808713Deletion of connective tissue growth factor ameliorates peritoneal fibrosis by inhibiting angiogenesis and inflammation
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Q38806090Expression of connective tissue growth factor in the livers of non-viral hepatocellular carcinoma patients with metabolic risk factors.
Q42202374Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis
Q43763309Fell-Muir lecture: Connective tissue growth factor (CCN2) -- a pernicious and pleiotropic player in the development of kidney fibrosis
Q35184582Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling
Q33622876Gingerol fraction from Zingiber officinale protects against gentamicin-induced nephrotoxicity
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Q48492207Plasma CTGF is independently related to an increased risk of cardiovascular events and mortality in patients with atherosclerotic disease: the SMART study
Q26784039Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy
Q39002130Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2).
Q41988029Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes.
Q40155862Role of ESAT-6 in renal injury by regulating microRNA-155 expression via TLR4/MyD88 signaling pathway in mice with Mycobacterium tuberculosis infection
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Q87207661Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes

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